Drug Type Small molecule drug |
Synonyms Risovalisib + [2] |
Target |
Mechanism PI3Kα inhibitors(Phosphatidylinositol 3 kinase alpha inhibitors) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Inactive Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationSpecial Review Project (CN) |
Molecular FormulaC25H33F3N8O8S2 |
InChIKeyCYWUJTNXNJVGLY-UHFFFAOYSA-N |
CAS Registry1494684-33-1 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
PIK3CA-related overgrowth syndrome | Phase 2 | CN | 09 May 2023 | |
PIK3CA-related vascular malformations | Phase 2 | CN | 09 May 2023 | |
Fallopian Tube Clear Cell Adenocarcinoma | Phase 2 | CN | 12 Jul 2022 | |
Fallopian Tube Clear Cell Adenocarcinoma | Phase 2 | CN | 12 Jul 2022 | |
Ovarian clear cell carcinoma | Phase 2 | JP | 13 Aug 2021 | |
Ovarian clear cell carcinoma | Phase 2 | CN | 13 Aug 2021 | |
Primary clear cell peritoneal carcinoma | Phase 2 | CN | 13 Aug 2021 | |
Primary clear cell peritoneal carcinoma | Phase 2 | JP | 13 Aug 2021 | |
Esophageal Carcinoma | Phase 2 | CN | 10 May 2018 | |
Advanced Malignant Solid Neoplasm | Phase 1 | CN | 17 May 2018 |
NCT04856371 (ASCO2024) Manual | Phase 1 | 52 | (PIK3CA-mutations without prior fulvestrant treatment) | (alawaiuksg) = hyperglycaemia (17.3%), rash (15.4%), stomatitis (13.5%), weight decreased (7.7%), decreased appetite (5.8%), diarrhoea (5.8%) and hypokalaemia (5.8%) jlvruwhmfo (agxcbugztu ) View more | Positive | 24 May 2024 | |
(RP2D) | |||||||
NCT03544905 (Pubmed) Manual | Phase 1 | PIK3CA H1047R mutant Solid Tumors PIK3CA Mutation | 51 | (overall) | (tdqzwaxruc) = subrrnhwey ltplkrytbh (fwdtrulyhp ) View more | Positive | 16 Nov 2022 |
(patients with PIK3CA mutations) | (xpeeqjtsis) = jlxhuutnvh dnzhntrtrm (agzefmnpwh ) |