This study is designed to assess the systemic exposure and pharmacokinetics of sunscreen active ingredients (avobenzone, oxybenzone, ecamsule, octocrylene homosalate, octisalate and octinoxate) when sunscreen product is applied under maximal use conditions.
Part 1 is an open-label, randomized, 4-arm study in 24 healthy adult subjects with the primary objective to explore whether the active components (avobenzone, oxybenzone, ecamsule and octocrylene) of 4 sunscreen products (1 sunscreen product in each arm) are absorbed into the systemic circulation when a sunscreen product is applied under maximal use conditions.
One sunscreen product with the highest avobenzone exposure will be selected for the second part of the study. If there is no quantifiable exposure of avobenzone for any of the sunscreen products, the formulation with the highest oxybenzone exposure will be selected for Part 2. In addition, 3 new sunscreen products are included in Part 2.
Part 2 is an open label, 4-arm study in 48 healthy adult subjects with the primary objective to assess the pharmacokinetics of the active components in the selected product from Part 1 and 3 additional products with a combination of active ingredients (avobenzone, oxybenzone, octocrylene, ecamsule homosalate, octisalate and octinoxate as applicable/contained in the different products).

Start Date18 Jul 2018

Sponsor / Collaborator

US Food & Drug Administration

[+1]

NCT02668536

/ CompletedPhase 1IIT

Assessing the Safety and Efficacy of Multifunctional Skin-adhesive Nanoparticles for UV Protection in Humans

The initial focus of the study will be on safety, sun protection factor (SPF) characterization, and substantivity (duration of protection) studies. The primary outcome of the study will be to measure the sun protection factor (SPF) of a bioadhesive nanoparticles (BNP) formulation in 20-25 healthy volunteers with fair skin.

Start Date17 Jul 2017

Sponsor / Collaborator

Yale University

100 Clinical Results associated with Oxybenzone

100 Translational Medicine associated with Oxybenzone

100 Patents (Medical) associated with Oxybenzone

2,301

Literatures (Medical) associated with Oxybenzone

01 Jan 2027·COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Interactive effects of ocean acidification and benzophenone-3 on mussel physiology: A biomarker-based approach

Article

Author: Cesar, Augusto ; Pusceddu, Fábio Hermes ; de Castro, Micheli Rosa ; Lopes, Fernanda Chaves ; Patrocinio, Guilherme Toledo Alves ; Martins, Camila de Martinez Gaspar

Benzophenone-3 (BP3), a widely used ultraviolet (UV) filter in personal care products and industrial applications, is an emerging concern in aquatic ecosystems due to its lipophilicity, bioaccumulation potential, and toxicity to marine biota. Its occurrence in marine environments coincides with ocean acidification driven by rising atmospheric CO₂ emissions, which disrupts the bicarbonate buffer system and reduces pH. This study investigated the acute effects (96 h exposure) of BP3 (at realistic concentrations of 0.2 and 2 μg/L) under 3 pH conditions (8.1- the current South Atlantic condition- and 7.6 and 7.3 as projected acidification scenarios for 2100 and 2300, respectively) in the brown mussel Perna perna. The effects were investigated through analysis of hemocyte viability and biomarkers related to detoxification (glutathione S-transferase, glutathione, glutamate cysteine ligase, and reduced glutathione), oxidative stress (antioxidant capacity against peroxyl radicals and lipid peroxidation), and biomineralization (carbonic anhydrase and Ca²⁺ATPase), measured in the gills, digestive gland, and mantle. Despite BP3-induced activation of glutathione-related detoxification pathways, as evidenced by increased GSH levels and GST activity, particularly in the gills, hemocyte viability decreased after BP3 exposure, with the greatest reduction at pH 7.3. Lipid peroxidation (LPO) also increased in the gills and digestive gland under acidified conditions, with the magnitude of the response varying according to BP3 concentration. CA and Ca²⁺ATPase activities were more strongly influenced by acidification than by BP3 exposure, although their responses were tissue-specific and, in some cases, modulated by BP3 exposure. Multivariate analyses identified pH as the primary driver of biomarker responses.

01 Dec 2026·ENVIRONMENTAL POLLUTION

Additives in microplastics shape biofilm composition during aging and favour antibiotic-resistant microorganisms

Article

Author: Kalčíková, Gabriela ; Korošin, Nataša Čelan ; Klun, Barbara ; Kim, Changhae ; Jung, Jinho ; Zidar, Živa ; Klančnik, Anja ; Novak, Janja ; Starin, Mark ; Rozman, Ula

Plastic additives are emerging as active agents that shape the environmental impacts of microplastics. In this study, we investigated how a polyethylene microplastic formulation containing the commonly used UV filter benzophenone-3 (BP-3) affects aging and biofilm colonization in freshwater. The additive-containing formulation altered the density and crystallinity of polyethylene particles and predisposed the material for faster surface transformation and formation of pits and cracks during aging. At the same time, it suppressed biofilm formation, reduced the development of extracellular polymeric substances by microorganisms, and specifically affected phototrophic microorganisms. Microbial community profiling revealed a shift from cyanobacteria-dominated biofilms to heterotrophic, chemically more resilient taxa, accompanied by enrichment of antibiotic resistance genes. Despite comparable genetic potential for polymer degradation, microbial activity was inhibited, indicating a trade-off between abiotic and biotic degradation. These results indicated that the tested additive-containing polyethylene formulation reduces microplastics stability and alters biofilm composition, highlighting the importance of considering additives in assessments of microplastic persistence and environmental effects.

01 Dec 2026·CHEMICO-BIOLOGICAL INTERACTIONS

Chemical proteomic identification of STUB1 as a direct target of benzophenone-3 reveals disrupted NRF2 signaling in chondrocytes

Article

Author: Yang, Ye ; Zou, Jiarong ; Wu, Runtao ; Cao, Haitao ; Xu, Huadong ; Li, Zhanyi ; Li, Yingjun ; Zhao, Wenxia ; Wang, Chunyan ; Zhu, Zhenyu ; Wei, Shasha ; You, Zhenqiang

Osteoarthritis (OA) is a common age-related degenerative joint disease, and emerging evidence implicates environmental chemical exposures as potential contributors. Benzophenone-3 (BP-3), a widely used ultraviolet filter frequently detected in human biospecimens, has been associated with increased OA risk, yet its direct molecular targets and mechanisms of cartilage toxicity remain unclear. Here, we applied an alkyne-tagged BP-3 probe combined with click chemistry-enabled chemical proteomics (SILAC-ABPP), transcriptomics, network toxicology, and experimental validation to investigate the molecular mechanisms underlying BP-3-induced cartilage toxicity. SILAC-ABPP identified the E3 ubiquitin ligase STUB1 as a direct cellular target of BP-3, which was further supported by cellular thermal shift assays and LC-MS/MS analysis. BP-3 exposure significantly increased STUB1 expression both in vivo and in vitro. Network toxicology and transcriptomic integration further implicated NRF2 in the STUB1-associated response to BP-3. BP-3-induced suppression of NRF2 was substantially attenuated by STUB1 knockdown, supporting a functional relationship between STUB1 and NRF2 in the cellular response to BP-3. STUB1 knockdown also attenuated BP-3-induced extracellular matrix disruption and ferroptosis-associated alterations, whereas NRF2 deficiency further aggravated these stress responses in chondrocytes. Chronic BP-3 exposure in mice recapitulated key pathological changes, including increased MMP13 expression, loss of collagen II, and altered ferroptosis-associated markers in articular cartilage. Collectively, these findings identify STUB1 as a direct molecular target of BP-3 and implicate STUB1-associated disruption of NRF2-dependent antioxidant responses in BP-3-induced cartilage toxicity.

News (Medical) associated with Oxybenzone

24 Jun 2026

·www.einpresswire.com

HistoSpring Announces Issuance of U.S. Patent for Methods Predicting ER-Mediated DNA Damage

Novel technology provides a new approach for identifying estrogenic compounds associated with genomic instability and breast cancer risk This patent advances understanding of how estrogen receptor signaling contributes to DNA damage and breast cancer risk, helping support future cancer prevention and safety research.” — Joseph Jerry, Ph.D., Director of the Biorepository, HistoSpring SPRINGFIELD, MA, UNITED STATES, June 24, 2026 / EINPresswire.com / -- HistoSpring , a leading provider of biomedical services and resources for advancing oncology research and precision medicine, today announced the issuance of U.S. Patent No. 12,590,950 B2, titled “Methods for Predicting ER-Mediated DNA Damage.” The newly issued patent expands HistoSpring’s portfolio supporting cancer research and translational discovery. The patent covers methods for identifying estrogenic compounds and endocrine-disrupting chemicals that induce estrogen receptor (ER)-mediated DNA damage and genomic instability in breast cells. The invention provides a new method for evaluating how compounds may contribute to breast cancer risk through estrogen receptor signaling pathways. It also can be used to guide the selection of therapies for treatment of ER+ breast cancers. The patented technology measures biomarkers associated with DNA damage, including γH2AX intensity and R-loop formation, following exposure to estrogenic compounds. Research supporting the patent demonstrated that compounds such as estradiol, benzophenone-3 (BP3), and propyl paraben (PP) can induce ER-mediated genomic instability in breast epithelial cells. The work may provide a platform for: • Breast cancer risk assessment • Environmental chemical screening • Endocrine disruptor evaluation • Toxicology and drug development research “This patent represents an important step forward in understanding how estrogen receptor signaling contributes to genomic instability and breast cancer risk in a subset of women,” said Joseph Jerry, Ph.D., Director of Biorepository. “Our findings establish a new framework for evaluating how estrogenic compounds may contribute to DNA damage at the molecular level. We believe this work has the potential to advance cancer risk assessment , strengthen chemical safety evaluation, and support future discoveries in breast cancer biology and prevention research.” About HistoSpring HistoSpring is a specialized biomedical company providing histology services, digital pathology, biomarker analysis, and research resources to support translational discovery and oncology research. The company combines traditional histology expertise with advanced imaging, automated staining, and HALO ® AI–driven tissue analysis to support biomarker development, spatial biology, and precision medicine research. HistoSpring also provides flexible wet lab resources and access to cell and tissue models to help accelerate scientific discovery and therapeutic development. For more information visit www.HistoSpring.com . For direct inquiries contact us at info@histospring.com / 413-794-0523. Lisa Strunin HistoSpring +1 781-738-7180 email us here Visit us on social media: LinkedIn Legal Disclaimer: EIN Presswire provides this news content "as is" without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.

16 Jun 2025

·www.lerner.ccf.org

This research team develops new UV blockers for skin cancer prevention

When it comes to skin cancer prevention, sunscreen is often the first line of defense. As more research emerges about unintended effects sunscreen may have on our bodies and the environment, Cleveland Clinic dermatologist Edward Maytin, MD, PhD, and biomedical engineer Vijay Krishna, PhD, are developing a new active ingredient for sunscreen. Drs. Krishna and Maytin have determined that their product – Photosorb – holds potential for a safer, more effective option for skin cancer prevention. Sunscreen safeguards our skin from damage in two ways: Ingredients called UV blockers/absorbers protect us from skin cancer by preventing ultraviolet (UV) light from damaging the DNA in our cells. Antioxidants and aspirin-like ingredients shield us from sunburn, preventing the inflammatory response that our skin and immune system generate in response to the DNA damage caused by UV rays. Sun protection factor (SPF) measures a sunscreen’s combined protective effect against DNA damage and sunburn. Because many UV blocking chemicals are harmful at high concentrations, most sunscreen companies use combinations of ingredients that offer more protection from sunburn than from DNA damage, to achieve a high SPF. The problem with this setup, Dr. Maytin says, is that the immune system activities triggered by sunburn can actually help repair DNA damage and prevent skin cancer. “Ironically enough, a sunscreen that’s very good at protecting against sunburn might actually cause harm by promoting skin cancer in the long run,” he says. Based on recent evidence, the FDA has raised concerns about specific UV-blocking ingredients being absorbed into our bloodstream (a list of these ingredients can be found here). A few chemicals, like oxybenzone and avobenzone, are known hormone disruptors in our blood. Many other chemicals on the list have not been tested for safety in our bloodstreams. “The safest UV blockers are zinc oxide and titanium dioxide. They don’t really get absorbed, and the few particles that do aren't dangerous in our blood,” Dr. Maytin says. “However, even with these UV blockers there is room for improvement. They feel greasier and can leave white streaks on our faces.” Dr. Krishna and Dr. Maytin teamed up to improve the UV blockers currently available. The team’s goal was to develop a UV blocker that protects our skin from cancer as much as it protects us from burning. Dr. Krishna’s team leads the chemistry and synthesis and Dr. Maytin brings a biological and clinical perspective. Together, they developed and patented Photosorb. Photosorb is a water-soluble, carbon-based molecule. In 2006, Dr. Krishna showed that a similar type of molecule can absorb UV light and block titanium dioxide photocatalysis, a chemical reaction involving light absorption. Dr Krishna and his team developed Photosorb by modifying the 2006 chemical to enhance its UV light-absorbing properties. With the help of Cleveland Clinic Innovations and funding from the Case Coulter Translational Research Partnership, the team used an unbiased third party to do efficacy and safety tests for their compound. These tests showed that Photosorb blocks all wavelengths of UV light in a way that is safer and more effective than the current standard. “Photosorb passed every single safety test,” says Dr. Krishna. “This was very, very exciting because there's no sunscreen on the market that can show safety in all of the tests like ours did at high concentrations.” Because Photosorb is safe at high levels, Drs. Krishna and Maytin say it can contribute more to sunscreen’s SPF rating than current UV blockers do. The team is currently preparing their sunscreen for the last batch of regulatory tests before commercializing their product. “I don't think we would have been able to do any of this without both of our expertise, so I’m glad we were able to collaborate and potentially improve skin care and quality of life for people worldwide,” Dr. Maytin says.

23 Aug 2024

·pharma.economictimes.indiatimes.com

Govt bans 156 medicines including antibiotics, painkillers, multivitamins: Here is the full list

New Delhi: In a significant move aimed at safeguarding public health, the Indian government has banned 156 fixed-dose combination (FDC) drugs, including a variety of antibiotics, painkillers, multivitamins, and medications for treating fever and hypertension. This decision marks the largest crackdown on FDCs since 2016, when 344 such drugs were prohibited. The Union Ministry of Health and Family Welfare issued a gazette notification on Thursday, officially prohibiting the manufacture, sale, and distribution of the banned FDCs. The ban was based on the recommendations of an expert panel that reviewed a total of 324 FDCs. Impact on Pharmaceutical Industry The banned FDCs include popular combinations such as mefenamic acid and paracetamol injections, commonly used for pain relief and fever, and omeprazole magnesium with dicyclomine HCl, used to treat abdominal pain. The ban is expected to impact major pharmaceutical companies, including Sun Pharmaceuticals, Cipla, Dr. Reddy's Laboratories, Torrent Pharmaceuticals, and Alkem Laboratories. Fixed Dose Combinations Drug Banned List Here is a table listing all 156 banned Fixed Dose Combinations (FDCs) SN Fixed Dose Combination (FDC) 1 Amylase + Protease + Glucoamylase + Pectinase + Alpha Galactosidase + Lactase + Beta-Gluconase + Cellulase + Lipase + Bromelain + Xylanase + Hemicellulase + Malt diastase + Invertase + Papain 2 Antimony Potassium Tartrate + Dried Ferrous Sulphate 3 Benfotiamine + Silymarin + L-Ornithine L-aspartate + Sodium Selenite + Folic acid + Pyridoxine hydrochloride 4 Bismuth Ammonium Citrate + Papain 5 Cyproheptadine HCl + Thiamine HCl + Riboflavine + Pyridoxine HCl + Niacinamide 6 Cyproheptadine Hydrochloride + Tricholine Citrate + Thiamine Hydrochloride + Riboflavine + Pyridoxine Hydrochloride 7 Rabeprazole Sodium (As enteric coated tablet) + Clidinium Bromide + Dicyclomine HCl + Chlordiazepoxide 8 Fungal Diastase + Papain + Nux vomica Tincture + Cardamom Tincture + Casein Hydrolysed + Alcohol 9 Mefenamic Acid + Paracetamol Injection 10 Omeprazole Magnesium + Dicyclomine HCl 11 S-adenosyl methionine + Metadoxine + Ursodeoxycholicacid BP + L-Methylfolate Calcium eq. to L- Methylfolate + Choline bitartratee + Silymarin + L-ornithine Laspartate + Inositol + Taurine 12 Silymarin + Thiamine Mononitrate + Riboflavin + Pyridoxine HCl + Niacinamide + Calcium pantothenate + Vitamin B12 13 Silymarin + Pyridoxine HCl + Cyanocobalamin + Niacinamide + Folic Acid 14 Silymarin + Vitamin B6 + Vitamin B12 + Niacinamide + Folic acid + Tricholine Citrate 15 Sodium Citrate + Citric Acid Monohydrate Flavored with Cardamom Oil, Caraway Oil, Cinnamon Oil, Clove Oil, Ginger Oil + Alcohol 16 Sucralfate + Acelofenac 17 Sucralfate + Domperidone + Dimethicone 18 Sucralfate + Domperidone 19 Tincture Ipecacuanha + Tincture Urgenia + Camphorated Opium Tincture + Aromatic Spirit of Ammonia + Chloroform + Alcohol 20 Ursodeoxycholic Acid + Metformin HCl 21 Weak Ginger tincture + Aromatic Spirit of Ammonia + Peppermint Spirit + Chloroform + Sodium Bicarbonate + Compound Cardamom + Alcohol 22 Sucralfate + Pantoprazole Sodium + Zinc Gluconate + Light Magnesium Carbonate 23 Aloe + Vitamin E Soap 24 Povidone Iodine+ Metronidazole + Aloe 25 Azelaic acid + Tea Tree Oil + Salicylic acid + Allantoin + Zinc oxide + Aloe vera + Jojoba oil + Vitamin E + Soap noodles 26 Azithromycin + Adapalene 27 Calamine + Aloes + Allantoin 28 Calamine + Diphenhydramine Hydrochloride + Aloe + Glycerine + Camphor 29 Chlorphenesin + Zinc oxide + Starch 30 Clindamycin Phosphate + Zinc acetate 31 Gamma Benzene Hexachloride + Benzocaine 32 Glucosamine hydrochloride + Diacerein + Menthol + Camphor + Capsaicin 33 Hydroxyquinone 2.0%w/w + Octyl Methoxycinnamate 5.0% w/w + Oxybenzone 30 % w/w 34 Ketoconazole +Zinc Pyrithione +D-Panthenol +Tea Tree Oil +Aloes 35 Ketoconazole +Aloe vera+ Vitamin A Acetate 36 Ketoconazole +Aloes + ZPTO 37 Kojic Acid +Arbutin +Octinoxate +Vitamin E + Mulberry 38 Lornoxicam +capsaicin +menthol+ camphor 39 Lornoxicam + Thiocolchicoside +Oleum Lini +Menthol + Methyl salicylate 40 Menthol + Aloe vera Topical Spray 41 Menthol +Lignocaine HCl +Aloe vera gel +Clotrimazole +Diphenhydramine 42 Miconazole nitrate + Gentamicin + Fluocinolone Acetonide +Zinc Sulphate 43 Miconazole +Tinidazole 44 Minoxidil +Aminexil+ Alcohol 45 Minoxidil +Azelaic acid + saw palmetto 46 Minoxidil +Aminexil 47 Pine Bark extract+ Kojic acid +Sodium Ascorbyl Phosphate 48 Povidone Iodine +Tinidazole +Zinc sulphate 49 Povidone Iodine + Ornidazole + Dexpanthenol 50 Salicyclic acid +Aloe vera+ Allantoin +D-Panthenol 51 Silver sulphadiazine +Chlorhexidine Gluconate solution +Allantoin + Aloe vera gel +Vitamin E acetate 52 Sodium salicylate + Zinc gluconate + Pyridoxine HCl 53 Tetracycline + Colistin Sulphate 54 Clomiphene +Ubidecarenone 55 Combikit of Clomiphene Citrate + Estradiol Valerate 56 Flavoxate HCl +Ofloxacin 57 Clomiphene Citrate +N-Acetylcysteine 58 Primerose Oil +Cod liver oil 59 Sildenafil Citrate +Papaverine +L-Arginine 60 Tranexamic acid +Mefenamic acid + Vitamin K1 61 Divalproex Sodium +Oxcarbazepine 62 Divalproex Sodium + Levetiracitam 63 Ergotamine tartrate +Caffeine + Paracetamol +Prochlorperazine maleate 64 Piracetam + Ginkgo biloba extracts + Vinpocetin 65 Ginkgo biloba + methylcobalamin 66 Ginkgo biloba + methylcobalamin + Alpha lipoic acid +Pyridoxine HCl 67 Ginseng Extract +Dried extract of Ginkgo Biloba 68 Meclizine HCl+ Paracetamol + Caffeine 69 Nicergoline + Vinpocetine 70 Gamma Linolenic Acid + Methylcobalamin 71 Beclomethasone Dipropionate + Neomycin Sulphate + Clotrimazole + Lignocaine HCl 72 Boric acid+ Phenylephrine HCl + Naphazoline Nitrate + Menthol + Camphor 73 Naphazoline HCl + Chlorpheniramine Maleate + Zinc Sulphate + Hydroxy Propyl Methyl Cellulose 74 Chlorpheniramine Maleate + Naphazoline HCl + Zinc Sulphate + Sodium Chloride + Hydroxy Propyl Methyl Cellulose 75 Chlorpheniramine Maleate + Naphazoline HCl + Hydroxy Propyl Methyl Cellulose 76 Chlorpheniramine Maleate + Sodium Chloride + Boric Acid + Tetrahydrozoline HCl 77 Chlorpheniramine Maleate + Phenylephrine HCl + Antipyrine 78 Ketorolac Tromethamine + Chlorpheniramine Maleate + Phenylephrine HCl + Hydroxy Propyl Methyl Cellulose 79 Ketorolac Tromethamine + Flurometholone 80 Naphazoline HCl + Zinc Sulphate + Boric Acid + Sodium Chloride+ Chlorpheniramine Maleate 81 Naphazoline HCl + Hydroxy Propyl Methyl Cellulose + Boric Acid + Borax + Menthol + Camphor 82 Naphazoline HCl + Hydroxy Propyl Methyl Cellulose + Chlorpheniramine Maleate SN Fixed Dose Combination (FDC) 83 Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride + Menthol + Camphor 84 Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride + Sodium Chloride + Hydroxy Propyl Methyl Cellulose 85 Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride + Sodium Chloride + Methylparaben 86 Methenamine + Sodium Benzoate + Benzyl Alcohol 87 Paracetamol + Phenylephrine Hydrochloride + Chlorpheniramine Maleate 88 Paracetamol + Phenylephrine Hydrochloride + Chlorpheniramine Maleate + Caffeine 89 Propoxyphene + Chlorpheniramine Maleate 90 Propoxyphene + Phenylephrine Hydrochloride + Chlorpheniramine Maleate 91 Propoxyphene + Diphenhydramine Hydrochloride + Phenylephrine Hydrochloride 92 Sodium Benzoate + Sodium Citrate + Citric Acid 93 Vitamin A Palmitate + Vitamin C + Vitamin E + Vitamin B6 + Vitamin B12 94 Vitamin A Palmitate + Vitamin C + Vitamin E + Niacinamide 95 Vitamin B6 + Vitamin B12 + Vitamin C 96 Vitamin B6 + Vitamin B12 + Niacinamide 97 Vitamin B12 + Vitamin B6 + Vitamin C + Folic Acid 98 Vitamin B12 + Vitamin B6 + Niacinamide + Folic Acid 99 Vitamin C + Vitamin E + Vitamin A + Niacinamide 100 Vitamin D + Calcium + Magnesium 101 Vitamin D + Calcium + Magnesium + Zinc 102 Calcium + Vitamin D + Vitamin K 103 Calcium + Vitamin D + Magnesium + Zinc 104 Calcium + Vitamin D + Vitamin K + Magnesium 105 Calcium + Vitamin D + Vitamin K + Magnesium + Zinc 106 Vitamin E + Vitamin A + Vitamin C + Niacinamide 107 Vitamin E + Vitamin A + Vitamin C + Folic Acid 108 Vitamin E + Vitamin A + Vitamin C + Biotin 109 Vitamin E + Vitamin A + Vitamin C + Vitamin B12 110 Vitamin E + Vitamin C + Folic Acid 111 Vitamin E + Vitamin C + Biotin 112 Vitamin E + Vitamin C + Vitamin B12 113 Vitamin E + Vitamin C + Zinc 114 Calcium + Vitamin D + Omega-3 Fatty Acids 115 Calcium + Vitamin D + Omega-3 Fatty Acids + Vitamin K 116 Calcium + Vitamin D + Omega-3 Fatty Acids + Vitamin K + Magnesium 117 Calcium + Vitamin D + Omega-3 Fatty Acids + Vitamin K + Zinc 118 Vitamin A + Vitamin C + Vitamin E + Beta-Carotene 119 Vitamin A + Vitamin C + Vitamin E + Beta-Carotene + Zinc 120 Vitamin C + Vitamin E + Beta-Carotene 121 Vitamin C + Vitamin E + Beta-Carotene + Zinc 122 Vitamin C + Vitamin E + Selenium 123 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids 124 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids + Magnesium 125 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids + Zinc 126 Vitamin D + Calcium + Vitamin K + Omega-3 Fatty Acids + Biotin 127 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Selenium 128 Vitamin E + Vitamin A + Vitamin C + Zinc 129 Vitamin E + Vitamin A + Vitamin C + Selenium 130 Vitamin E + Vitamin A + Vitamin C + Biotin 131 Vitamin E + Vitamin A + Vitamin C + Folic Acid + Niacinamide 132 Vitamin E + Vitamin C + Beta-Carotene + Zinc 133 Vitamin C + Vitamin E + Biotin + Folic Acid 134 Vitamin C + Vitamin E + Beta-Carotene + Folic Acid 135 Vitamin C + Vitamin E + Beta-Carotene + Selenium 136 Vitamin E + Vitamin C + Beta-Carotene + Biotin 137 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Biotin 138 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Selenium 139 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Vitamin B12 140 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Vitamin B6 141 Vitamin D + Calcium + Omega-3 Fatty Acids + Vitamin K + Folate 142 Calcium + Vitamin D + Magnesium + Vitamin K + Omega-3 Fatty Acids 143 Calcium + Vitamin D + Magnesium + Vitamin K + Biotin 144 Calcium + Vitamin D + Magnesium + Vitamin K + Selenium 145 Calcium + Vitamin D + Magnesium + Vitamin K + Vitamin B12 146 Calcium + Vitamin D + Magnesium + Vitamin K + Folate 147 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Vitamin B6 148 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Vitamin B12 149 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Folic Acid 150 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Biotin 151 Calcium + Vitamin D + Vitamin K + Omega-3 Fatty Acids + Selenium 152 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids 153 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Zinc 154 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Biotin 155 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Selenium 156 Vitamin A + Vitamin C + Vitamin E + Omega-3 Fatty Acids + Vitamin B12

Drug Approval

100 Deals associated with Oxybenzone

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D05309	Oxybenzone	D02B	DB01428

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NCT03582215 (CTgov)	Phase 1	-	72	Part 1: Cream (Part 1: Cream)	deymmkmnyo(hpleqyxvzj) = zoquwaqnkm jtivcxrpac (cxuvmzzbto, 32) View more	-	21 Apr 2020
				Octocrylene+Avobenzone+Oxybenzone (Part 1: Lotion)	deymmkmnyo(hpleqyxvzj) = gtpvbdlvrs jtivcxrpac (cxuvmzzbto, 46) View more

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