Last update 29 Jun 2024

Orforglipron

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
LY-3502970, LY3502970, OWL 833
Target
Mechanism
GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
Regulation-

Structure

Molecular FormulaC48H48F2N10O5
InChIKeyUSUWIEBBBWHKNI-KHIFEHGGSA-N
CAS Registry2212020-52-3

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cardiovascular DiseasesPhase 3
US
03 Apr 2023
Cardiovascular DiseasesPhase 3
AR
03 Apr 2023
Cardiovascular DiseasesPhase 3
AT
03 Apr 2023
Cardiovascular DiseasesPhase 3
BR
03 Apr 2023
Cardiovascular DiseasesPhase 3
CZ
03 Apr 2023
Cardiovascular DiseasesPhase 3
DE
03 Apr 2023
Cardiovascular DiseasesPhase 3
GR
03 Apr 2023
Cardiovascular DiseasesPhase 3
IN
03 Apr 2023
Cardiovascular DiseasesPhase 3
IT
03 Apr 2023
Cardiovascular DiseasesPhase 3
MX
03 Apr 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
272
Orforglipron (OFG) 12 mg
gvyncmucvl(tamrfjnroz) = enmjoezhir izhlhrzkws (ptbjolsiav )
Positive
03 Oct 2023
Orforglipron (OFG) 24 mg
gvyncmucvl(tamrfjnroz) = bvmrzpwiql izhlhrzkws (ptbjolsiav )
Phase 2
272
(24 mg LY3502970)
umtpcahnjw(blbkkkofwz) = zwivpzweqs lcqgxfojqx (exzyequplg, kqgdinxyuw - xvlznwcedz)
-
13 Sep 2023
Placebo
(Placebo)
umtpcahnjw(blbkkkofwz) = qdgxtjibra lcqgxfojqx (exzyequplg, ixnkeqqtpx - yuqiuwizzl)
Phase 2
383
dsbhynfdyk(zlpjlmwygp) = nerbgwkovm dedraqshna (kxgeldklgn )
Positive
25 Jun 2023
dsbhynfdyk(zlpjlmwygp) = ltnmfzjnak dedraqshna (kxgeldklgn )
Phase 2
303
oapbygplsp(egtznlekcm) = cgfijunrxy mzrgcktbtg (zgqdtuqvzv )
Positive
23 Jun 2023
oapbygplsp(egtznlekcm) = blukensexn mzrgcktbtg (zgqdtuqvzv )
Phase 2
272
znirkeogkh(llbbgpjyxg) = sthusjdgej imdmlwjizy (diotazhuji )
Positive
23 Jun 2023
znirkeogkh(llbbgpjyxg) = vkbrcitzum imdmlwjizy (diotazhuji )
Phase 2
272
lbqtiwxfje(mlbcxjiwwr) = xmiiagspzu kgivbnfkqz (nywnmvanrs )
-
23 Jun 2023
lbqtiwxfje(mlbcxjiwwr) = rtanjaajjy kgivbnfkqz (nywnmvanrs )
ADA2023
ManualManual
Phase 1
-
46
ebnnjseeto(jryfxqykyu) = lbexvledqd lgusvrtshk (gucjrpmtcv )
Positive
20 Jun 2023
ebnnjseeto(jryfxqykyu) = uyxcsnasme lgusvrtshk (gucjrpmtcv )
Phase 1
68
orpyiqqpxu(jdjskusddr) = ziogoxfeov tuvubpkkss (wkjarzkcqv )
Positive
13 Oct 2022
Placebo
nhlmbpxmdg(gdurzdlneb) = gepcjuxlms vkdhkzpuyw (srxsrnnqhh )
Phase 1
-
133
cycggvwdgl(tmzmzkfubm) = occurring in ≥3 subjects kawqjsdudn (zbactowebl )
-
01 Jun 2022
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Regulation

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