This study is designed to determine the pharmacokinetic and pharmacodynamic response of dorzagliatin 75 mg twice daily following 7-day administration in individuals with pancreatic insufficient cystic fibrosis and abnormal glucose tolerance when compared to randomized, double-blind 7-day administration of placebo in a cross-over fashion. We hypothesize that dorzagliatin administration will result in significant drug concentrations and improved glucose tolerance, early-phase insulin secretion, glucagon suppression, and hepatic glycogen storage assessed during a standardized mixed-meal tolerance test.

Start Date01 Dec 2025

Sponsor / Collaborator

University of Pennsylvania

NCT06976658

/ Not yet recruitingPhase 2IIT

Evaluating a Novel, Allosteric Glucokinase Activator in Monogenic Diabetes Secondary to Inactivating Glucokinase Mutations: a Randomised, Cross-over Trial

Evaluating a novel, allosteric glucokinase activator in monogenic diabetes secondary to inactivating glucokinase mutations: a randomised, cross-over trial

Start Date28 May 2025

Sponsor / Collaborator

The Chinese University of Hong Kong

NCT06671340

/ Not yet recruitingNot ApplicableIIT

Effects of Repeated Dose of Dorzagliatin on Insulin Secretion, Glucagon Release and Incretin Function in Intermediate Hyperglycemia and Type 2 Diabetes

A total of 30 subjects will be recruited 15 with intermediate hyperglycemia and 15 in the tyep 2 diabetes group respectively. Eligible participants will undergo hyperglycemic-clamp/oral glucose tolerance at baseline and after 4 weeks of dorzagliatin treatment.

Start Date02 Apr 2025

Sponsor / Collaborator

The Chinese University of Hong Kong

100 Clinical Results associated with Dorzagliatin

100 Translational Medicine associated with Dorzagliatin

100 Patents (Medical) associated with Dorzagliatin

Literatures (Medical) associated with Dorzagliatin

01 Nov 2025·DIABETES

Effects of Dorzagliatin, a Glucokinase Activator, on α- and β-Cell Function in Individuals With Impaired and Normal Glucose Tolerance

Article

Author: Chan, Juliana C.N. ; Wang, Ke ; Chen, Li ; Luk, Andrea O.Y. ; Yau, Tiffany ; Ferrannini, Ele ; Chow, Elaine ; Tam, Claudia H.T. ; Lim, Cadmon K.P. ; Tsoi, Sandra T.F. ; Ma, Ronald C.W. ; Bai, Zhengli ; Poon, Emily W.M. ; Mari, Andrea ; Kong, Alice P.S. ; Fan, Baoqi

Article Highlights:

Dorzagliatin is a dual-acting allosteric glucokinase (GCK) activator that increases β-cell glucose sensitivity and second-phase insulin in GCK monogenic diabetes of the young. Actions of dorzagliatin on α- and β-cell function in normal and impaired glucose tolerance are unknown. In this study, dorzagliatin increased second-phase insulin in individuals with impaired glucose tolerance while suppressing glucagon in participants with normal glucose tolerance during a hyperglycemic clamp. With increasing glucose, plasma glucagon and total GLP-1 levels declined progressively. A modest to moderate positive correlation between glucagon and total GLP-1 was observed under both dorzagliatin and placebo treatments.

01 Sep 2025·ANALYTICA CHIMICA ACTA

An innovative method for simultaneous separation and determination of monosaccharide and sugar alcohol isomers associated with glycometabolism in beagle plasma using gas chromatography-mass spectrometry

Article

Author: Zhang, Zunjian ; Xiao, Wen ; Tian, Yuan ; Liu, Qiaorong ; Ren, Haihui ; Han, Jiameng

BACKGROUND:

Tracking changes in plasma concentrations of monosaccharides and sugar alcohols related to glycometabolism, which plays a role as the main source of energy, is of great significance for the treatment of metabolic diseases. However, analysis of monosaccharides and sugar alcohols has always been a difficult task due to the high polarity of the polyhydroxy structure and the presence of a large number of isomers. So far, no suitable method has been developed for simultaneous determination of monosaccharides and sugar alcohols in beagle plasma.

RESULTS:

This work performed an innovative gas chromatography-mass spectrometry method for the simultaneous chromatographic separation and absolute quantification of 11 monosaccharides and sugar alcohols associated with glycometabolism. After derivatization, monosaccharides converted to be oxime acetylated derivatives and sugar alcohols transformed into acetylated derivatives. All analytes achieved good separation after chromatographic conditions were optimized, especially the selection of mid-polarity capillary column(6 % cyanopropyl phenyl and 94 % dimethyl polysiloxane). The improvement of derivatization efficiency through single factor and response surface optimization ensured a high sensitivity, with LOQ of each analyte in the range of 0.2-50 ng/mL. The established method was fully validated in terms of linearity and range, sensitivity, accuracy and precision, recovery, matrix effect, stability, dilution integrity and proved to be reliable, which was applied to the comparative study on hypoglycemic effect of two antidiabetic agents with different pharmacological mechanisms, dorzagliatin and metformin, as well as possible metabolic pathways affected by them.

SIGNIFICANCE:

This method solves the problems of multiple peaks after derivatization and frequent co-elution of analytes in previous analytical methods, significantly enhances derivatization efficiency of ketoses, which provides a promising approach for simultaneous analysis of aldose, ketose, and sugar alcohol. It offers new insights into a more comprehensive research on glycometabolism rather than merely focusing on glucose.

01 Sep 2025·Anti-inflammatory & anti-allergy agents in medicinal chemistry

Inclusive Drug Designing of Novel Indole Derivatives using Rationale, Pharmacophore Mapping and Molecular Docking

Article

Author: Mehra, Anuradha ; Sangwan, Rekha ; Mehra, Aryan ; Sharma, Rahul ; Mittal, Amit

Background::

The presence of insufficient insulin signaling in type 2 diabetes arises due to either insulin resistance or impaired insulin secretion, ultimately leading to elevated blood glucose levels, a condition known as hyperglycemia. Diabetes poses a pervasive worldwide challenge, with its prevalence steadily surging in both developed and developing nations. A promising avenue for improving the management of diabetes type 2 involves the exploration of glucokinase activators as an innovative therapeutic target. Notably, a recent breakthrough in this area has been the market approval granted by the Japanese FDA for the use of the innovative GKA, Dorzagliatin, in the treatment of diabetes type 2.

Objective::

To augment the management of diabetes type 2 and mitigate the undesirable side effects linked to prolonged use of conventional medications, this research endeavor sought to create innovative glucokinase activators.

Methods::

The ZINC database yielded a collection of 56 compounds, each showcasing a 40% structural similarity to 1-(phenylsulfonyl)-1H-indole-2-carboxylic acid. These compounds, all featuring the distinctive indole core, were meticulously selected for further investigation. Structural illustrations were crafted using ChemBioDraw Ultra, and 1.5.6 AutoDock Vina was for molecular docking. The Swiss ADME algorithm facilitated online log P predictions, while the software PKCSM was utilized to forecast the toxicity profiles of the leading compounds. DFT analysis was done to ensure the stability of compounds by using Gaussian 16 quantum chemistry software and Mulliken charge distributions used to optimize molecular geometries.

Results::

Among all the compounds, RS33 and RS37 exhibited the highest affinities for GK receptors, with the docking scores of -8.93 and -8.44 kcal/mol, respectively. These compounds follow Lipinski’s Rule, indicating promising absorption and excretion profiles through the gastrointestinal tract. Compared to standard drugs Dorzagliatin (GKA) and MRK (co-crystallized ligand), both RS33 and RS37 demonstrate no AMES toxicity, skin sensitization, and hepatotoxicity. RS43 is the most stable compound as it has high ΔE, η, and χ in DFT analysis.

Conclusion::

The novel-designed lead molecules demonstrate an enhanced pharmacokinetic profile, superior binding affinity, and minimal toxicity, based on computational study. These attributes make them promising candidates for further optimization as glucokinase activators.

News (Medical) associated with Dorzagliatin

21 Nov 2024

·www.businesswire.com

Versant Ventures Unveils Pep2Tango Therapeutics Inc.

POTOMAC, Md.--( BUSINESS WIRE )--Versant Ventures today announced the debut of Pep2Tango Therapeutics Inc., a startup focused on innovative, next-generation weight loss therapies. Proceeds from the significant, undisclosed round will support development of the company’s novel unimolecular tetra-receptor agonist peptides to treat obesity and related conditions. GLP-1-based therapies have proven efficacy in treating obesity and associated co-morbidities, but come with significant drawbacks. These include up to 40% of weight loss from muscle mass reduction, potentially leading to long-term side effects, especially in elderly patients. This limitation, in addition to tolerability issues, reduces the long-term utility of these agents. Pep2Tango’s lead drug candidates are engineered to overcome these drawbacks. They are unimolecular multi-receptor peptide agonists that target GLP-1, GIP, amylin and calcitonin receptors. This unique combination of targets in one molecule is truly differentiated with key advantages compared with first-generation drugs on the market and therapies currently in development. Preclinical studies of Pep2Tango’s molecules have demonstrated superior weight loss versus tirzepatide, primarily through selective fat mass loss with preservation of muscle mass, improved blood lipid profiles, better glycemic control, and beneficial effects on the liver. The company’s programs were developed by a deeply experienced team led by President, CEO and Chairperson Cristina Rondinone, Ph.D., and CSO Soumitra Ghosh, Ph.D. Dr. Rondinone previously was president of Cellarity, and SVP and head of cardiovascular, renal and metabolic diseases at AstraZeneca plc. Prior to that, she held roles of increasing responsibility in cardio-metabolic disease research and development at MedImmune Inc., Roche and Abbott Laboratories, where she led the research and development of multiple molecules that moved to clinical trials including Rezdiffra ™ , dorzagliatin and bentracimab. Dr. Ghosh is a co-founder of multiple biotech companies and served as executive director for research at Amylin Pharmaceuticals Inc., where he was involved in development efforts culminating in the approvals of Byetta ® , Symlin ® , Bydureon ® and Myalept ® . Dr. Ghosh also served as president of the Peptide Therapeutics Foundation. “We are delighted that Versant is backing Pep2Tango as we advance our programs towards clinical development,” said Dr. Rondinone. “There is a critical need to develop safe and highly efficacious drug therapies for obesity that preserve muscle mass and Pep2Tango’s approach should positively impact the lives of patients.” “We are thrilled to partner with the seasoned team of experts at Pep2Tango,” said Carlo Rizzuto, Ph.D., managing director at Versant and a Pep2Tango board member. “We are convinced that the company’s tetra-receptor agonists have best-in-category potential with respect to magnitude and quality of weight loss, as well as improving metabolic and cardiovascular health, that could redefine obesity treatment.” Pep2Tango Therapeutics is focused on CMC development activities to scale up drug candidate manufacturing and on running IND-enabling studies for a rapid transition to first-in-human clinical studies. An IND submission is expected in 2025. About Pep2Tango Therapeutics Inc. Pep2Tango Therapeutics is a biotechnology company founded in 2021 by seasoned pharmaceutical executives with a long track record of successful drug development. The company’s vision is to develop next generation peptide drugs that target unmet medical needs, including for metabolic, endocrine, CNS and cardiovascular disorders. Pep2Tango’s novel drug development approach for obesity focuses on unimolecular peptides that target multiple receptors, allowing for superior weight loss efficacy, muscle mass preservation, improved tolerability, and streamlined development and manufacturability. The company is backed by Versant Ventures. About Versant Ventures Versant Ventures is a leading healthcare venture capital firm committed to helping exceptional entrepreneurs build the next generation of great companies. The firm’s emphasis is on biotechnology companies that are discovering and developing novel therapeutics. With $5.5 billion under management and offices in the U.S., Canada and Europe, Versant has built a team with deep investment, operating and R&D expertise that enables a hands-on approach to company building. Since the firm’s founding in 1999, more than 100 Versant companies have achieved successful acquisitions or IPOs. For more information, please visit www.versantventures.com .

Drug ApprovalIPO

16 Feb 2023

·www.prnewswire.com

111, Inc. Hosts Hua Medicine Launches First Official Flagship Store

SHANGHAI, Feb. 16, 2023 /PRNewswire/ -- On February 15, 2023, 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company in China, announced that during the HuaTangNing® Market Launch for Innovative Commerce Cooperation, Dr. Yu Gang, Co-founder and Executive Chairman of 111, and Dr. Chen Li, Founder and CEO of Hua Medicine (HKEx stock code: 2552.HK), jointly unveiled the plaque of Hua Medicine's first official online flagship store on 111. 111 is committed to digitally connecting patients with medicine and healthcare services, aspiring to build itself into an integrated online and offline healthcare platform. The official flagship store launched by Hua Medicine on 111 will serve as an official window to showcase the outstanding brand image of Hua Medicine and an important platform for Hua Medicine to better serve both patients and doctors. For its part, 111 will further help Hua Medicine expand its commercial layout, broaden its drug supply and distribution channels, and explore innovative and diversified supply service modes. The official flagship store will provide patients with Hua Medicine's innovative treatment concepts, carry out patient education on drug safety and other topics, and release the latest news from Hua Medicine. Dr. Yu Gang, Co-founder and Executive Chairman of 111, said: "Hua Medicine is a leader in innovative drug research and commercialization in China. Over the years, it has devoted itself to the research and development of original drugs. HuaTangNing®, a first-in-class drug of its kind, is from Hua Medicine. The official opening of its flagship store on 111 is a timely and innovative measure taken by a Chinese innovative pharmaceutical company to embrace the Internet. At the same time, it also marks a key milestone for 111 and Hua Medicine in the exploration of online cooperation. 111 will work with Hua Medicine to make cutting-edge innovative drugs more accessible for diabetes patients, empower diabetes treatment as well as patient management, and contribute value to society." Dr. Li Chen, Founder and CEO of Hua Medicine, said: "111 is a benchmark player in China's Internet medicine and healthcare industry, equipped with leading digital technology and smart supply chain. We are very much looking forward to Hua Medicine's cooperation with 111, as we provide innovative solutions of health management and medical services through the online flagship store. In the future, Hua Medicine will continue to explore partnership opportunities with Internet channels to benefit more diabetic patients." About Hua Medicine Hua Medicine is an innovative drug development and commercialization company based in Shanghai, China, focused on developing novel therapies for patients worldwide with unmet medical needs. Based on global resources, Hua Medicine teams up with global high-caliber people to develop breakthrough technologies and products, which contribute a global innovation in diabetes care. As Hua Medicine's cornerstone product (dorzagliatin tablets), targeting the glucose sensor, glucokinase, restores glucose sensitivity in T2D patients and stabilizes the imbalance of blood glucose levels in patients, it has been approved by the National Medical Products Administration (NMPA) of China in September 2022. It can be used alone or in combination with metformin hydrochloride-tolerated T2D patients. For those patients with chronic kidney disease (CKD) and Type 2 diabetes (i.e., diabetes kidney disease), no dose adjustment is required. About 111, Inc. 111, Inc. (NASDAQ: YI) ("111" or the "Company") is a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China. The Company provides consumers with better access to pharmaceutical products and healthcare services directly through its online retail pharmacy, 1 Pharmacy, and indirectly through its offline virtual pharmacy network. The Company also offers online healthcare services through its internet hospital, 1 Clinic, which provides consumers with cost-effective and convenient online consultation, electronic prescription service, and patient management service. In addition, the Company's online platform, 1 Medicine, serves as a one-stop shop for pharmacies to source a vast selection of pharmaceutical products. With the largest virtual pharmacy network in China, 111 enables offline pharmacies to better serve their customers with cloud-based services. 111 also provides an omni-channel drug commercialization platform to its strategic partners, which includes services such as digital marketing, patient education, data analytics, and pricing monitoring. For more information on 111, please visit: . Forward-Looking Statements This press release contains forward-looking statements. These statements constitute "forward-looking" statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and as defined in the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements can be identified by terminology such as "will," "expects," "anticipates," "future," "intends," "plans," "believes," "estimates," "target," "confident" and similar statements. Among other things, the Business Outlook and quotations from management in this announcement, as well as 111's strategic and operational plans, contain forward-looking statements. 111 may also make written or oral forward-looking statements in its periodic reports to the U.S. Securities and Exchange Commission, in its annual report to shareholders, in press releases and other written materials and in oral statements made by its officers, directors or employees to third parties. Such statements are based upon management's current expectations and current market and operating conditions and relate to events that involve known or unknown risks, uncertainties and other factors, all of which are difficult to predict and many of which are beyond the Company's control. Forward-looking statements involve inherent risks, uncertainties and other factors that could cause actual results to differ materially from those contained in any such statements. Potential risks and uncertainties include, but are not limited to, uncertainties as to the Company's ability comply with extensive and evolving regulatory requirements, its ability to compete effectively in the evolving PRC general health and wellness market, its ability to manage the growth of its business and expansion plans, its ability to achieve or maintain profitability in the future, its ability to control the risks associated with its pharmaceutical retail and wholesale businesses, and the Company's ability to meet the standards necessary to maintain listing of its ADSs on the Nasdaq Global Market, including its ability to cure any non-compliance with Nasdaq's continued listing criteria. Further information regarding these and other risks, uncertainties or factors is included in the Company's filings with the U.S. Securities and Exchange Commission. All information provided in this press release is as of the date of this press release, and 111 does not undertake any obligation to update any forward-looking statement as a result of new information, future events or otherwise, except as required under applicable law. SOURCE 111, Inc.

27 Sep 2021

·www.biospace.com

Hua Medicine May be Sending Type 2 Diabetes into Remission

Is it a DREAM? On September 26, news emerged from Suzhou, China, that a glucokinase activator being developed by Chinese pharmaceutical company Hua Medicine may be heading toward making diabetes remission a reality. “DREAM” is a follow-up, observational clinical study of the Phase III SEED clinical study of dorzagliatin, a first-in-class glucokinase activator, which is being conducted in drug-naive Type 2 diabetes patients to determine its safety and efficacy. Its main objective is to determine if patients who participated in the SEED trial and achieved glycemic control as defined by investigators could maintain this for a minimum of 52 weeks without the intervention of any glucose-lowering medication. And many of them did. The analysis showed a 52-week glucose remission rate of 65.2% among the 69 patients being followed. Professor Jianhua Ma, director of the department of endocrinology at Nanjing First Hospital, standing member of the Chinese Diabetes Society and one of the principal investigators on the study, presented the findings at the 6th China BioMed Innovation and Investment Conference. “Dorzagliatin, a new class of glucokinase activator, has demonstrated the ability to effectively improve early phase insulin secretion and beta cell function and insulin resistance resulting in Type 2 diabetes remission,” Ma said, adding that dorzagliatin monotherapy had previously demonstrated stable long-term efficacy and a good safety pro the SEED study. “The DREAM study again showed positive results, where patients who reached normal blood glucose level after dorzagliatin treatment were able to maintain their blood glucose level and beta cell function after discontinuation of medication.” Ma went on to say that the study is of “great significance in expanding the treatment options for type 2 diabetes.” Hua Medicine is a clinical-stage drug development company based out of Shanghai, China, focussing on novel therapies for the treatment of diabetes and CNS disorders. According to Hua Medicine CEO, founder, and chief scientific officer Dr. Li Chen, China has the world’s largest number of diabetes patients, with the number of type 2 patients exceeding 120 million. He added that prevention and control of diabetes have become a “strategic imperative” in addressing this major public health issue. “The positive results of the DREAM study have strengthened our confidence in the cure of Type 2 diabetes,” Chen said. “Hua Medicine will continue to explore the broad prospects of monotherapy and combination therapy based on dorzagliatin, while further conducting typing studies and using a combination of big data and artificial intelligence for the precise treatment of Type 2 diabetes.” Per the Centers for Disease Control and Prevention (CDC), more than 34 million Americans have diabetes (around 1 in 10), with approximately 90-95% of the cases being Type 2. This is not the first time the idea of diabetes remission has been proposed. In 2020, Dr. Ebaa Al Ozairi, chief medical officer at the Dasman Diabetes Institute in Kuwait said that Type 2 diabetes remission with weight loss is possible and most likely for younger patients who sustain more weight loss and have had the disease for a shorter period of time. “We can no longer talk and tell our patients that diabetes is a chronic disease,” Ozairi, who is also an American Board of Physician Nutrition specialist, said during a presentation at ObesityWeek Interactive. “We have to give them the hope that we know today that diabetes remission is not a myth and is actually a reality. We really need to rethink treatment of Type 2 diabetes, so if it is treated early, we can achieve remission.” In 2018, Danish diabetes leader Novo Nordisk announced that it was upping its focus on stem cell therapy which replaces the beta cells missing in Type 1 diabetes patients with the aim of freeing patients from their dependence on insulin. In February, the company gave an update on its cell therapy efforts, saying that it expected to investigational new drug (IND) application toward the end of 2022, but that the initial indication would be in Parkinson’s disease, not diabetes. In January, Vertex Pharmaceuticals announced that the U.S. Food and Drug Administration (FDA) had approved an IND for its own cell therapy for Type 1 diabetes. Featured Jobs on BioSpace

First in ClassCell Therapy

100 Deals associated with Dorzagliatin

External Link

KEGG	Wiki	ATC	Drug Bank
D11342	-	-	DB15123

R&D Status

Approved

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Diabetes Mellitus, Type 2	China	Hua Medicine (Shanghai) Co., Ltd.	30 Sep 2022

Developing

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Glucose Intolerance	Phase 2	-	The Chinese University of Hong Kong	01 Aug 2022
Hyperglycemia	Clinical	Hong Kong	The Chinese University of Hong Kong	02 Apr 2025
Diabetic Nephropathies	IND Application	China	Hua Medicine (Shanghai) Co., Ltd.	-
Alzheimer Disease	Preclinical	China	Hua Medicine (Shanghai) Co., Ltd.	13 Oct 2022
Diabetes Mellitus, Type 1	Preclinical	China	Hua Medicine (Shanghai) Co., Ltd.	13 Oct 2022
Metabolic Dysfunction Associated Steatohepatitis	Preclinical	China	Hua Medicine (Shanghai) Co., Ltd.	13 Oct 2022
Metabolic Syndrome	Preclinical	China	Hua Medicine (Shanghai) Co., Ltd.	11 Dec 2017

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ADA 12025 \| ADA 22025 Manual	Not Applicable	Diabetes Mellitus, Type 2	72	Dorzagliatin	lybtrcguds(ypyzczjrbd) = hqfprgzbar rasxglkrnk (kcihbekftd ) View more	Positive	20 Jun 2025
DREAM (ADA2022)	Not Applicable	Diabetes Mellitus, Type 2	69	Dorzagliatin	rxtigsygcr(pglqahvkeg) = evcomoivlr bhpsqxprhh (kgrfumaosl, 53.4 - 77.0)	-	01 Jun 2022
NCT03173391 (SEED, Pubmed) Manual	Phase 3	Diabetes Mellitus, Type 2	463	Dorzagliatin	vrvwrdbqbt(ykbkpewbzc) = robtynzsge epzxjttrvd (njnotivctq, -1.19 to -0.95)	Positive	12 May 2022
				Placebo	vrvwrdbqbt(ykbkpewbzc) = dvyybatham epzxjttrvd (njnotivctq, -0.68 to -0.32)
NCT03141073 (DAWN, Pubmed \| Nat Med) Manual	Phase 3	Diabetes Mellitus, Type 2	767	metformin+Dorzagliatin	yonbgibans(zhhfdkdacs) = tpfowbtokm hezvngyeue (uzpakxyuvl, -1.11 to -0.93)	Positive	12 May 2022
				metformin+Placebo	yonbgibans(zhhfdkdacs) = knzddtcuvs hezvngyeue (uzpakxyuvl, -0.45 to -0.26)
NCT03173391 (SEED, ADA2021)	Not Applicable	Diabetes Mellitus, Type 2	463	Dorzagliatin 75 mg	ovrqggfpfr(sosyymyszg) = zjkfeswkyo yhsxelnifx (tzhjigpxfo ) View more	Positive	01 Jun 2021
				Placebo	kwyknjdkdf(kxtvmpaopi) = mwlidbunlj qotpikjjji (egedwojode )
NCT03141073 (DAWN, ADA2021)	Not Applicable	Diabetes Mellitus, Type 2 Add-on	767	Dorzagliatin	wuissqfxfe(gbczzfqycd) = efedrkifye glcvbecjgr (nsepopbzvo )	Positive	01 Jun 2021
				Placebo	wuissqfxfe(gbczzfqycd) = ivxkgbuuhh glcvbecjgr (nsepopbzvo )
NCT03173391 (HMM0301 \| SEED, NEWS) Manual	Phase 3	Diabetes Mellitus, Type 2	463	Dorzagliatin	jndyeydrfe(mzjdvrqduz) = enjmcioapn ntixybutfi (jjvndzfmep ) View more	Positive	18 Jun 2020
				Placebo	jndyeydrfe(mzjdvrqduz) = jrqfyxgthg ntixybutfi (jjvndzfmep ) View more
ADA2020	Not Applicable	Diabetes Mellitus, Type 2	463	Dorzagliatin 75 mg	fnihwlcufh(daovfxezhe) = texwtgvutz tnwzeqiquo (natxvwgzcs ) View more	Positive	01 Jun 2020
				Placebo	jgoocijgsx(yfyyftmkwo) = hcbxqabjeq rytdifuaqw (ggprcrsoii ) View more
NCT02561338 (CTgov)	Phase 2	Diabetes Mellitus, Type 2	258	HMS5552 (HMS5552 Dose 1)	whuhiorcjb(jdwskxymbv) = thxkghgapt odpkceaait (izxrzryhsp, rwaurmhvmy - cibjtljcnc) View more	-	10 Mar 2020
				HMS5552 (HMS5552 Dose 2)	whuhiorcjb(jdwskxymbv) = oizdjeiags odpkceaait (izxrzryhsp, injwpgnuhu - tjsfkyurqo) View more
NCT02386982 (Pubmed) Manual	Phase 1	Diabetes Mellitus, Type 2	24	HMS5552 (75 mg twice daily)	uajuvdfwrx(sodlvapdea) = wwdsqwetyb acmfkcowli (apucrpcyvi ) View more	Positive	01 Sep 2018
				HMS5552 (75 mg once daily)	uajuvdfwrx(sodlvapdea) = bdkaovxmey acmfkcowli (apucrpcyvi ) View more

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