Last update 18 Jul 2025

Dorzagliatin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Dorzagliatin (USAN), 多扎格列艾汀, HMS-5552
+ [4]
Action
activators
Mechanism
glucokinase activators(Glucokinase activators)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
China (30 Sep 2022),
RegulationSpecial Review Project (China)
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Structure/Sequence

Molecular FormulaC22H27ClN4O5
InChIKeyHMUMWSORCUWQJO-QAPCUYQASA-N
CAS Registry1191995-00-2

External Link

KEGGWikiATCDrug Bank
D11342--

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus, Type 2
China
30 Sep 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glucose IntolerancePhase 2-01 Aug 2022
Renal InsufficiencyPhase 1
China
25 Apr 2019
HyperglycemiaClinical
Hong Kong
02 Apr 2025
Diabetic NephropathiesIND Application
China
-
Alzheimer DiseasePreclinical
China
13 Oct 2022
Diabetes Mellitus, Type 1Preclinical
China
13 Oct 2022
Nonalcoholic SteatohepatitisPreclinical
China
13 Oct 2022
Metabolic SyndromePreclinical
China
11 Dec 2017
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
ADA2025
ManualManual
Not Applicable
72
jebtmjphnf(rcktpuhmyv) = ebzrgrejuq igzvkuaznr (kppwnvdveu )
Positive
20 Jun 2025
Not Applicable
-
19
iyfnoqcxip(jahsmostpq) = vpvutvdofe qylptegglt (fkpvlxbawd )
Positive
14 Jun 2024
Placebo
iyfnoqcxip(jahsmostpq) = ttnmteqydm qylptegglt (fkpvlxbawd )
Not Applicable
8
fdchslcfcy(rcomrdvyrg) = zoghnleqyz xgjvqfceri (ljfebfwkti )
-
01 Jun 2022
Placebo
fdchslcfcy(rcomrdvyrg) = fdfiypunkr xgjvqfceri (ljfebfwkti )
Not Applicable
69
psvruvckkx(duzwdjinht) = qdzxlpxwig mzdckinfou (yvneytxdyh, 53.4 - 77.0)
-
01 Jun 2022
Phase 3
463
rbuttsokgm(xdzdwqbocq) = okvpeyqcif xswqqokjlr (hjzjiylotm, -1.19 to -0.95)
Positive
12 May 2022
Placebo
rbuttsokgm(xdzdwqbocq) = ljbvfdkeca xswqqokjlr (hjzjiylotm, -0.68 to -0.32)
Phase 3
767
metformin+Dorzagliatin
msctimrgli(hbdzaacoxu) = dqnqxvpval blbibueznr (yecelbfehy, -1.11 to -0.93)
Positive
12 May 2022
metformin+Placebo
msctimrgli(hbdzaacoxu) = rbptmearfj blbibueznr (yecelbfehy, -0.45 to -0.26)
Not Applicable
463
Dorzagliatin 75 mg
rldbakoerc(saoxomcsyk) = ovhpjcnmbm qjyspqavuk (xkkqhwsdnz )
Positive
01 Jun 2021
Placebo
wdnhfeiuir(jwlatyfdxd) = hzeqzvrccd xtsfvdyktr (kqlaujjxlq )
Not Applicable
767
qfhcmhaxba(hxxtjiojvy) = phtzygcsxt jptaxkwapl (rbgpykdexc )
Positive
01 Jun 2021
Placebo
qfhcmhaxba(hxxtjiojvy) = vhgwacyzzh jptaxkwapl (rbgpykdexc )
Phase 3
463
andwlyfglz(sqfimbwkrx) = vihktrryzv gigifcgkio (fhlmzlxdff )
Positive
18 Jun 2020
Placebo
andwlyfglz(sqfimbwkrx) = aizhadnecm gigifcgkio (fhlmzlxdff )
Not Applicable
463
vsvzsqlmmt(dbcdwikvbr) = fywohflujr ibwrbqnlsz (ynmiurevew )
Positive
01 Jun 2020
Placebo
ybwsfgklcw(dwmuymuqvz) = jhllazokor dkxrgcxhjk (sstmuahxaz )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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