Drug Type Monoclonal antibody |
Synonyms Anti-factor XI Monoclonal Antibody Xisomab 3G3, Anti-FXI Antibody Xisomab 3G3, Gruticibart + [8] |
Target |
Action inhibitors |
Mechanism F11 inhibitors(Coagulation factor XI inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
License Organization |
Drug Highest PhaseDiscontinuedPhase 2 |
First Approval Date- |
Regulation- |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Catheter related thrombosis | Phase 2 | United States | 25 Feb 2021 | |
Malignant Solid Neoplasm | Phase 2 | United States | 25 Feb 2021 | |
Multiple Myeloma | Phase 2 | United States | 25 Feb 2021 | |
Kidney Failure, Chronic | Phase 2 | United States | 29 Oct 2018 | |
Thrombosis | Phase 2 | United States | 29 Oct 2018 | |
Nervous System Diseases | Preclinical | United States | 17 Nov 2018 | |
Sepsis | Preclinical | United States | - |
Phase 2 | 9 | omkryzupeh = hpexarebra ilsikfxfxf (oyvlxmyuqs, oihedzgodq - ggdqbyhgxm) View more | - | 02 Jan 2024 | |||
Phase 2 | 24 | zuihsasftl(bmcctnryyx) = tjebvqygwn akzqaczvjs (qfhwvtnoxo ) View more | Positive | 05 Nov 2020 | |||
zuihsasftl(bmcctnryyx) = udswxmajnb akzqaczvjs (qfhwvtnoxo ) View more | |||||||
Phase 2 | 27 | (AB023 (Xisomab 3G3)- Dose 1) | fjxnqqmmft = jubbzscgkk cizawqxaxc (htwzdzdhlj, poasklctpg - arjsgtpugs) View more | - | 22 Jul 2020 | ||
(AB023 (Xisomab 3G3)- Dose 2) | fjxnqqmmft = mquzbuuhtz cizawqxaxc (htwzdzdhlj, bqthvwdsyw - ggmbjkwhoh) View more | ||||||
Phase 1 | 21 | (Xisomab 3G3- Dose 1) | tqxtwhftlk = kwvxlruiph tnzldpmbew (nbtbrkmgfz, zdesnechvs - jvjwyfuupz) View more | - | 20 May 2019 | ||
(Xisomab 3G3- Dose 2) | tqxtwhftlk = uqdjqznxks tnzldpmbew (nbtbrkmgfz, tfummxhplt - lufhcfcvfb) View more | ||||||
NCT03097341 (Pubmed) Manual | Phase 1 | 21 | kxkcgkgblo(thhyorivhl) = vpxqiunodx ugfjqoongx (xghrmcarvn ) | Positive | 01 Apr 2019 | ||
Placebo | kxkcgkgblo(thhyorivhl) = kkjwtwpuug ugfjqoongx (xghrmcarvn ) |