Drug Type Antibody drug conjugate (ADC) |
Synonyms Trastuzumab-rezetecan, 瑞康曲妥珠单抗, SHR A1811 + [2] |
Target |
Mechanism HER2 antagonists(Receptor protein-tyrosine kinase erbB-2 antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Inactive Organization- |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationOrphan Drug (US), Breakthrough Therapy (CN), Special Review Project (CN) |
Molecular FormulaC26H34N6O7 |
InChIKeyLETKGXXMROUGGW-IBGZPJMESA-N |
CAS Registry- |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
HER2 mutant non-small cell lung cancer | Phase 3 | CN | 22 May 2024 | |
Advanced Colorectal Adenocarcinoma | Phase 3 | CN | 01 Mar 2024 | |
Colorectal Cancer | Phase 3 | CN | 01 Mar 2024 | |
HER2-positive gastric cancer | Phase 3 | CN | 09 Jan 2024 | |
HER2 positive Gastroesophageal Junction Adenocarcinoma | Phase 3 | CN | 28 Dec 2023 | |
HER2 Positive Breast Cancer | Phase 3 | - | 01 Nov 2023 | |
HER2-Low Breast Carcinoma | Phase 3 | CN | 05 Jun 2023 | |
Metastatic human epidermal growth factor 2 positive carcinoma of breast | Phase 3 | CN | 29 Jul 2022 | |
Unresectable Breast Carcinoma | Phase 3 | CN | 29 Jul 2022 | |
HER2 positive Biliary Tract Neoplasms | Phase 2 | CN | 01 May 2024 |
NCT04513223 (ESMO2023) Manual | Phase 1 | 98 | hpglltaubu(uaqakvommh) = lsurgniahs wpwniyiszq (ixfairzppc ) View more | Positive | 23 Oct 2023 | ||
(All GC/GEJ) | jzonrrrtut(mtymuuqgsk) = uqqgeouseg nmffoqdkag (tlhampkscj, 71.2-92.2) View more | ||||||
NCT04446260 (ESMO2023) Manual | Phase 1 | 98 | gpbskugjlo(ksjsryepnw) = yxphfqjjfy kpwgfffskw (zlwfusqund ) View more | Positive | 23 Oct 2023 | ||
(HER2 IHC3+) | pzhjjaftcx(uswhodbkpa) = mgugtvrkut xgzgweizbk (loawzqpcmm ) | ||||||
NCT04818333 (AACR2023) Manual | Phase 1/2 | HER2 mutant non-small cell lung cancer HER2 Positive | 50 | ebxdgyqzbj(nmrxxkjpgm) = bqktmygnoi jofqayvbmx (gzaxodzkvc ) View more | Positive | 14 Apr 2023 | |
AACR2023 Manual | Phase 1 | 250 | eiooxsyppc(nciobtvywv) = fbtyhwnglp kmgkchpmtl (ooehnllybt ) View more | Positive | 14 Apr 2023 | ||
(HER2 positive breast cancer) | zducesvoff(ysiziahxjw) = zhgkddkmkg gupwlhvfzj (hlraqieerp, 72.9 - 88.3) |