Effect of daily taurine supplementation for 6 months on age and metabolic biomarkers as well as physical fitness in 55-75-year-old women and men:the TauAge Study - TauAge

Start Date25 Sep 2024

Sponsor / Collaborator-

ChiCTR2400082614 / SuspendedNot ApplicableIIT

Efficacy of taurine add-on therapy in Angelman syndrome

Start Date01 Apr 2024

Sponsor / Collaborator-

NCT06639711 / Active, not recruitingPhase 1/2IIT

Taurine Affects the Progression of Senile Cataract: a Single-arm Pre-post Intervention Study

The aim of the current intervention study is to determine the effectiveness of taurine containing eye drops (available under brand name VIZILOTON) to prevent the progression of grade I and II senile cataract.
This study could answer:
* Dose continuous use of taurine-containing eye drops could prevent further deterioration of vision in mild cases of cataract?
* The acceptance/ compliance of participants to taurine-containing eye drops.
* Could long-term use of taurine-containing eye drops cause adverse effect(s)?
Participants will:
* Take taurine-containing eye drops (VIZILOTON eye drops) 4 times a day for one year.
* Visit eye clinic every 3 months for assessment and visual examination.
* Keep notes for their symptoms and their adherence to treatment.

Start Date10 Jul 2023

Sponsor / Collaborator

University of Anbar

100 Clinical Results associated with Taurine

100 Translational Medicine associated with Taurine

100 Patents (Medical) associated with Taurine

8,512

Literatures (Medical) associated with Taurine

01 Mar 2025·Neural Regeneration Research

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

Article

Author: Wang, Bin ; Ma, Ju-Yun ; Guo, Xin-Yian ; Li, Peng-Peng ; Pu, Hai-Wei ; Fan, Hai-Di ; Zhang, Yi-De ; Shen, Jian-Gang ; Qi, Su-Hua ; Chen, Jie ; Wang, Wan ; Huang, Lin-Yan

JOURNAL/nrgr/04.03/01300535-202503000-00029/figure1/v/2024-06-17T092413Z/r/image-tiff It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late stroke. Indeed, previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain tissue. Our previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke, but its specific role and mechanism are currently unclear. To simulate stroke in vivo, a middle cerebral artery occlusion rat model was established, with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic stroke. We found that in the early stage (within 24 hours) of ischemic stroke, neutrophils produced a large amount of hypochlorous acid, while in the recovery phase (10 days after stroke), microglia were activated and produced a small amount of hypochlorous acid. Further, in acute stroke in rats, hypochlorous acid production was prevented using a hypochlorous acid scavenger, taurine, or myeloperoxidase inhibitor, 4-aminobenzoic acid hydrazide. Our results showed that high levels of hypochlorous acid (200 μM) induced neuronal apoptosis after oxygen/glucose deprivation/reoxygenation. However, in the recovery phase of the middle cerebral artery occlusion model, a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and astrocytes. This suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion injury. Lower levels of hypochlorous acid (5 and 100 μM) promoted nuclear translocation of β-catenin. By transfection of single-site mutation plasmids, we found that hypochlorous acid induced chlorination of the β-catenin tyrosine 30 residue, which promoted nuclear translocation. Altogether, our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

01 Feb 2025·Behavioural Brain Research

Differential effects of chronic and intermittent administration of taurine on alcohol binge drinking in male rats

Article

Author: Sant'Ana, Bruna Haendchen ; Zilli, Gabriela Adriany Lisboa ; Sant’Ana, Bruna Haendchen ; Izolan, Lucas Dos Reis ; Pulcinelli, Rianne Remus ; Izolan, Lucas dos Reis ; Gomez, Rosane ; Leal, Mirna Bainy ; Marques, Douglas ; Bastiani, Caroline da Silveira

Episodic consumption of high doses of alcohol in a short period (binge drinking - BD) among adolescents is known to be harmful to their brain development. Chronic use of taurine increases voluntary alcohol consumption and shows an anxiolytic-like effect in rats. In this study, we evaluated the differential effects of chronic and intermittent taurine administration on alcohol consumption and behavioral changes in adolescent and young adult rats subjected to the BD model. Male Wistar rats (35 days old) were divided into 4 groups for daily intraperitoneal administration of saline (SAL); taurine, 100mg/kg (TAU); taurine on BD days and saline on intervals (TAU/SAL); and saline on BD days and taurine on intervals (SAL/TAU). They were exposed to 4 cycles of BD, with free access to alcoholic solution (20% w/v), for 2h, 3 days per week. At the end of the 3rd cycle, anxiety-like behaviors were assessed using the light-dark task. After euthanasia, plasma and prefrontal cortex samples were collected to measure corticosterone and BDNF levels, respectively. Chronic taurine treatment did not alter alcohol consumption in rats, whereas intermittent administration increased alcohol intake after 4 BD exposures (TAU/SAL: +19.4% and SAL/TAU: +21.6%). No anxiolytic-like effects were found by taurine administration, nor were there changes in serum corticosterone or BDNF levels in the frontal cortex of young adult rats. Intermittent taurine, but not chronic treatment, increased alcohol intake among rats after the second week of exposure. The translation of these results to humans is concerning since the combination of alcohol and drinks containing taurine is common among adolescent and young adult individuals.

01 Jan 2025·Journal of Ethnopharmacology

Integration of network pharmacology, UHPLC-Q exactive orbitrap HRMS technique and metabolomics to elucidate the active ingredients and mechanisms of compound danshen pills in treating hypercholesterolemic rats

Article

Author: Guo, Zhuoqian ; Xu, Bing ; Dai, Ziqi ; Cheng, Xuehao ; Xiong, Xiaomin ; Cheng, Sijin ; Li, Shanlan ; Zhang, Tong ; An, Jin ; Chen, Guangyun ; Wang, Nan ; Zhang, Zixuan ; Jiang, Guanghui ; Lei, Haimin

ETHNOPHARMACOLOGICAL RELEVANCEHypercholesterolemia (HLC) was a key risk factor for cardiovascular disease (CVD) characterized by elevated cholesterol levels, particularly LDL. While traditional Chinese medicine preparations Compound Danshen Pills(CDP) has been clinically used for hypercholesterolemia and coronary heart disease, its specific therapeutic effect on HLC remains understudied, necessitating further investigation into its mechanisms.AIM OF THE STUDYThe aim of this study was to explore the potential of CDP in treating HLC and elucidate its underlying mechanisms and active components.MATERIALS AND METHODSA hypercholesterolemic lipemia rat model induced by a high-fat diet was employed. Network pharmacology combined with UHPLC-Q exactive orbitrap HRMS technique was used to predict the active components, targets and mechanisms of CDP for HLC. Histological analysis and serum biochemical assays were used to assess the therapeutic effect of CDP and its main active ingredient Sa B on hypercholesterolemic lipemia rat model. Immunofluorescence assays and western blotting were used to verify the mechanism of CDP and Sa B in the treatment of HLC. Metabolomics approach was used to demonstrate that CDP and Sa B affected the metabolic profile of HLC.RESULTSOur findings demonstrated that both CDP and its main active ingredient Sa B significantly ameliorated hypercholesterolemic lipemic lesions, reducing levels of TC, LDL, AST, ALT, and ALP. Histological analysis revealed a decrease in lipid droplet accumulation and collagen fiber deposition in the liver, as well as reduced collagen fiber deposition in the aorta. Network pharmacology predicted potential targets such as PPARα and CYP27A1. Immunofluorescence assays and western blotting confirmed that CDP and Sa B upregulated the expression of Adipor1, PPARα and CYP27A1. Metabolomics analyses further indicated improvements in ABC transporters metabolic pathways, with differential metabolites such as riboflavin, taurine, and choline showed regression in levels after CDP treatment and riboflavin, L-Threonine, Thiamine, L-Leucine, and Adenosine showed improved expression after Sa B treatment.CONCLUSIONCDP and Sa B have been shown to alleviate high-fat diet-induced hypercholesterolemia by activating the PPAR pathway and improving hepatic lipid metabolism. Our study demonstrated, for the first time, the complex mechanism of CDP, Sa B in the treatment of hypercholesterolemia at the protein and metabolic levels and provided a new reference that could elucidate the pharmacological effects of traditional Chinese medicine on hypercholesterolemia from multiple perspectives.

News (Medical) associated with Taurine

08 Jun 2023

·www.drugs.com

Nutrient Taurine Might Help Extend Life, Animal Studies Show

THURSDAY, June 8, 2023 -- An amino acid found in meat, fish and energy drinks might be a key regulator of aging in animals, a new study suggests. However, experts warn that no one should start seeing Red Bull as a fountain of youth. Researchers found that deficiencies in the amino acid, called taurine, seemed to be a prime driver of aging in lab mice: Their taurine levels naturally declined with age, but giving middle-aged mice a daily taurine supplement for one year essentially slowed the aging process. Compared with lab mice fed a placebo supplement, the taurine-consuming mice survived 10% to 12% longer. These mice were also more likely to be living their best lab-mouse lives — staying leaner, maintaining stronger bones and muscles, showing fewer depression- and anxiety-like behaviors, and holding on to a "younger-looking" immune system. "Whatever we checked, taurine-supplemented mice were healthier and appeared younger than the control mice," said study leader Vijay Yadav , an assistant professor of genetics and development at Columbia University, in New York City. When the scientists repeated the supplement experiment in middle-aged monkeys, they observed similar effects. One major caution, the researchers and other experts said, is that mice and monkeys, studied in a controlled lab setting, are not people living their complicated lives out in the world. And the research offers no proof that taurine supplements can help humans live longer and healthier. "We do not recommend that people go out and buy taurine off the shelf," Yadav said. Instead, he and his colleagues think taurine supplements should be put to the test in a clinical trial. What that trial would look like is unclear, said study co-author Henning Wackerhage , a professor at Technical University of Munich, in Germany. But broadly, it could mean having middle-aged adults take taurine or a placebo every day, then following them over time to see if there are health differences between the two groups. Taurine is an amino acid that the human body synthesizes naturally, and it is also attained from food. Shellfish offer the biggest dose, Yadav said, but taurine is also found in beef and poultry (especially dark meat) and in small amounts in dairy products. Amino acids are typically "building blocks" that form proteins. But taurine is different, Wackerhage said: It's a free-form molecule that does not get incorporated into proteins. Research has suggested that taurine plays a role in the function of the central nervous system and immune system, and has anti-inflammatory and anti-oxidant properties. In people, it has not been clear whether the amino acid helps drive the aging process or "just goes along for the ride," Yadav said. In the new study, published June 8 in the journal Science, the researchers tested taurine supplements in lab animals only. But they did look at some human data, too. They found that among roughly 12,000 older adults in a European health study, those with higher taurine levels were less likely to have obesity or type 2 diabetes. That, however, only shows a correlation — not cause and effect, said Joseph Baur, a professor at the University of Pennsylvania Perelman School of Medicine, in Philadelphia. It could be that some human diseases drive down taurine levels, said Baur, who wrote a commentary published with the study. But, he added, that chicken-egg problem is why the animal experiments were so crucial. "They show for the first time that increasing taurine can be a driver of increased longevity," Baur noted. Still, that's an important research step — not lifestyle advice. For the average person today, Baur said, a healthy diet, exercise and not smoking should be the "foundation" of any healthy-aging strategy. "New ideas, like taurine supplementation, should always be approached with caution and studied in controlled clinical trials," Baur said. "It's much easier to screw things up than to make them better, even with molecules that seem likely to be safe." Another researcher who was not involved in the study said the findings are scientifically interesting, but worried about how the supplement industry will spin things. "They can start promoting this as an anti-aging supplement tomorrow," said Dr. Pieter Cohen , an associate professor at Harvard Medical School who studies the content and quality of commercial dietary supplements. Cohen noted that in the United States, supplements are not subject to the same regulations that medications are. That means they do not have to be proven effective before they are marketed, and consumers cannot be sure any supplement actually contains what's on the label. Yadav stressed that while taurine is in meat, diets heavy in meat have been tied to ill health effects. And, he said, that's not what his team studied. Nor did they study energy drinks, which would contain lots of other things, like caffeine and sugar. In yet another portion of the study, the researchers had a group of athletes and couch potatoes pedal away on exercise bikes to the point of exhaustion. Afterward, most showed an increased taurine level in the blood. But it's not clear, the experts said, whether regular exercise actually boosts the body's production of taurine, or whether taurine might be one reason that exercise is good for us. The researchers acknowledged that the range of benefits seen in the animal experiments "seem too good to be true." "My take," Wackerhage said, "is that taurine seems to hit the engine room of aging." Cohen had a more guarded take. With something as complicated as human aging, he said, it would be surprising if one amino acid wielded such power. The study was funded by government and foundation grants, and had no supplement industry involvement, the researchers said. Sources Vijay Yadav, PhD, assistant professor, genetics and development, Columbia University Vagelos College of Physicians and Surgeons, New York City Henning Wackerhage, PhD, professor, exercise biology, Technical University of Munich, Munich, Germany Joseph Baur, PhD, professor, physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia Pieter Cohen, MD, general internist, Cambridge Health Alliance, Somerville, Mass., associate professor, medicine, Harvard Medical School, Boston Science, June 9, 2023 Posted June 2023

08 Jun 2023

·www.sciencedaily.com

Taurine may be a key to longer and healthier life

A study finds that deficiency of taurine, a molecule produced in our bodies, drives aging, and taurine supplements can improve health and increase lifespan in animals. A deficiency of taurine -- a nutrient produced in the body and found in many foods -- is a driver of aging in animals, according to a new study led by Columbia researchers and involving dozens of aging researchers around the world. The same study also found that taurine supplements can slow down the aging process in worms, mice, and monkeys and can even extend the healthy lifespans of middle-aged mice by up to 12%. The study was published June 8 in Science. "For the last 25 years, scientists have been trying to find factors that not only let us live longer, but also increase healthspan, the time we remain healthy in our old age," says the study's leader, Vijay Yadav, PhD, assistant professor of genetics & development at Columbia University Vagelos College of Physicians and Surgeons. "This study suggests that taurine could be an elixir of life within us that helps us live longer and healthier lives." Anti-aging molecules within us Over the past two decades, efforts to identify interventions that improve health in old age have intensified as people are living longer and scientists have learned that the aging process can be manipulated. Many studies have found that various molecules carried through the bloodstream are associated with aging. Less certain is whether these molecules actively direct the aging process or are just passengers going along for the ride. If a molecule is a driver of aging, then restoring its youthful levels would delay aging and increase healthspan, the years we spend in good health. Taurine first came into Yadav's view during his previous research into osteoporosis that uncovered taurine's role in building bone. Around the same time, other researchers were finding that taurine levels correlated with immune function, obesity, and nervous system functions. "We realized that if taurine is regulating all these processes that decline with age, maybe taurine levels in the bloodstream affect overall health and lifespan," Yadav says. Taurine declines with age, supplementation increases lifespan in mice First, Yadav's team looked at levels of taurine in the bloodstream of mice, monkeys, and people and found that the taurine abundance decreases substantially with age. In people, taurine levels in 60-year-old individuals were only about one-third of those found in 5-year-olds. "That's when we started to ask if taurine deficiency is a driver of the aging process, and we set up a large experiment with mice," Yadav says. The researchers started with close to 250 14-month-old female and male mice (about 45 years old in people terms). Every day, the researcher fed half of them a bolus of taurine or a control solution. At the end of the experiment, Yadav and his team found that taurine increased average lifespan by 12% in female mice and 10% in males. For the mice, that meant three to four extra months, equivalent to about seven or eight human years. Taurine supplements in middle age improves health in old age To learn how taurine impacted health, Yadav brought in other aging researchers who investigated the effect of taurine supplementation on the health and lifespan in several species. These experts measured various health parameters in mice and found that at age 2 (60 in human years), animals supplemented with taurine for one year were healthier in almost every way than their untreated counterparts. The researchers found that taurine suppressed age-associated weight gain in female mice (even in "menopausal" mice), increased energy expenditure, increased bone mass, improved muscle endurance and strength, reduced depression-like and anxious behaviors, reduced insulin resistance, and promoted a younger-looking immune system, among other benefits. "Not only did we find that the animals lived longer, we also found that they're living healthier lives," Yadav says. At a cellular level, taurine improved many functions that usually decline with age: The supplement decreased the number of "zombie cells" (old cells that should die but instead linger and release harmful substances), increased survival after telomerase deficiency, increased the number of stem cells present in some tissues (which can help tissues heal after injury), improved the performance of mitochondria, reduced DNA damage, and improved the cells' ability to sense nutrients. Similar health effects of taurine supplements were seen in middle-aged rhesus monkeys, which were given daily taurine supplements for six months. Taurine prevented weight gain, reduced fasting blood glucose and markers of liver damage, increased bone density in the spine and legs, and improved the health of their immune systems. Randomized clinical trial needed The researchers do not know yet if taurine supplements will improve health or increase longevity in humans, but two experiments they conducted suggest taurine has potential. In the first, Yadav and his team looked at the relationship between taurine levels and approximately 50 health parameters in 12,000 European adults aged 60 and over. Overall, people with higher taurine levels were healthier, with fewer cases of type 2 diabetes, lower obesity levels, reduced hypertension, and lower levels of inflammation. "These are associations, which do not establish causation," Yadav says, "but the results are consistent with the possibility that taurine deficiency contributes to human aging." The second study tested if taurine levels would respond to an intervention known to improve health: exercise. The researchers measured taurine levels before and after a variety of male athletes and sedentary individuals finished a strenuous cycling workout and found a significant increase in taurine among all groups of athletes (sprinters, endurance runners, and natural bodybuilders) and sedentary individuals. "No matter the individual, all had increased taurine levels after exercise, which suggests that some of the health benefits of exercise may come from an increase in taurine," Yadav says. Only a randomized clinical trial in people will determine if taurine truly has health benefits, Yadav adds. Taurine trials are currently underway for obesity, but none are designed to measure a wide range of health parameters. Other potential anti-aging drugs -- including metformin, rapamycin, and NAD analogs -- are being considered for testing in clinical trials. "I think taurine should also be considered," Yadav says. "And it has some advantages: Taurine is naturally produced in our bodies, it can be obtained naturally in the diet, it has no known toxic effects (although it's rarely used in concentrations used ), and it can be boosted by exercise. "Taurine abundance goes down with age, so restoring taurine to a youthful level in old age may be a promising anti-aging strategy."

06 Jul 2022

·www.prnewswire.com

The Energy Drinks Market Is Estimated To Reach USD $89 Billion By 2027

FinancialNewsMedia.com News Commentary PALM BEACH, Fla., July 6, 2022 /PRNewswire/ -- The energy drinks market is on the way towards offering technological advancements that are gaining major popularity amongst the youngsters. Owing to certain health benefits like muscle and cardiovascular development has a positive tomorrow for the market. People are increasing their consciousness towards their health and hence, bringing about changes in their lifestyle. Also, there is an increase in awareness amongst the target audience related to the wellness products that help in understanding the positive impacts that these energy drinks and other products offer. Energy drinks are consumed in the form of a beverage and have a high concentration of taurine, stimulants, caffeine, guarana, and ginseng amongst others. As the name suggests, they are recognized as helping in enhancing physical performance and improvise mental alertness. Energy drinks are available in both carbonated and non-carbonated forms. They are different from sports drinks that are used as a replacement for electrolytes and water post any physical activity. A report from Market Research Future projected that the Energy Drinks Market valuation is estimated to reach USD 89 billion by 2027 registering a CAGR of 5.80%. The report said that: "The manufacturers claim that these products tend to increase energy levels after consumption. Also, these products promise mental and physical stimulation which is acting as one of the major reasons for the wide-scale development of the Energy Drinks Market during the forecast period. Taurine is a major component that is known to help in the development of skeletal development and smooth cardiovascular functioning." Active companies in the markets this week include Splash Beverage Group, Inc. (NYSE: SBEV), AMCON Distributing Company (NYSE American: DIT), TravelCenters of America Inc. (NASDAQ: TA), Constellation Brands, Inc. (NYSE: STZ), Anheuser-Busch InBev (NYSE: BUD), Market Research Future continued: "The energy drinks market worldwide consumption is increasing amongst young adults on a large scale. Weekly, there is a 15.8% increase in worldwide consumption. The Global consumer survey and other studies show that employed and young people that have a low educational level have a higher stance for weekly energy drink consumption. This is likely to increase the demand and hence, positively impact the rate at which the market will grow during the forecast period. The largest market share in the global market is held by the European region owing to increasing awareness regarding fitness, health, and preventive health care. Obesity and the presence of a high geriatric population also drive market growth." Splash Beverage Group, Inc. (NYSE American: SBEV) BREAKING NEWS: Splash Beverage Group Gains New Distribution with Convenience Store Chain Brewer Oil Company for TapouT Distribution Across New Mexico - Splash Beverage Group, Inc. ("Splash" or the "Company"), a portfolio company of leading beverage brands, today announced that it that it will now be selling all four SKUs of TapouT Performance Drinks into Convenience Store Chain, Brewer Oil Company in New Mexico. Brewer Oil Company, headquartered in Albuquerque, New Mexico was founded in 1958 with an initial service station in Artesia. Brewer Oil continues to serve wholesale and retail customers with not only automotive services, but with retail convenience stores throughout New Mexico from Albuquerque to Espanola, Las Cruces to Capital, and Roswell to Loving. "Our product availability continues to grow with this latest retail expansion news," said Robert Nistico, Splash Beverage Group's Chairman and CEO. "Our growth strategy has always involved targeting the large, national distributors, regional grocers, and retail outlets. This is very much aligned with that strategy. It's also more evidence of the strength of our new distribution relationship with Kalil Bottling Company who has done an amazing job in Arizona and who ultimately made this retail authorization happen. Brewer Oil has a top convenience store chain in New Mexico with strong reputation for fresh and ready to eat food with a broad beverage selection." CONTINUED… Read the Splash Beverage full press release by going to: Additional recent developments in the markets this week include: AMCON Distributing Company (NYSE American: DIT), an Omaha, Nebraska based consumer products company, recently announced fully diluted earnings per share of $5.19 on net income available to common shareholders of $3.0 million for its second fiscal quarter ended March 31, 2022. "We are pleased with our results for the second fiscal quarter. Our management team has remained highly focused on delivering a consistently superior level of customer service in a highly challenging operating environment," said Christopher H. Atayan, AMCON's Chairman and Chief Executive Officer. Mr. Atayan further noted, "AMCON continues to seek out acquisition opportunities for distributors who want to align with our growing platform and customer centric management philosophy." The wholesale distribution segment reported revenues of $379.5 million and operating income of $6.3 million for the second quarter of fiscal 2022. The retail health food segment reported revenues of $12.4 million and operating income of $0.7 million for the second quarter of fiscal 2022. TravelCenters of America Inc. (NASDAQ: TA) recently announced that it will issue a press release containing its second quarter 2022 financial results after the Nasdaq closes on Monday, August 1, 2022. On Tuesday, August 2, 2022 at 10:00 a.m. Eastern Time, Chief Executive Officer Jonathan Pertchik, President Barry Richards and Chief Financial Officer and Treasurer Peter Crage will host a conference call to discuss these results. The conference call telephone number is (877) 329-4614. Participants calling from outside the United States and Canada should dial (412) 317-5437. No pass code is necessary to access the call from either number. Participants should dial in about 15 minutes prior to the scheduled start of the call. A replay of the conference call will be available through Tuesday, August 9, 2022. To hear the replay, dial (412) 317-0088. The replay pass code is 9164944. A live audio webcast of the conference call will also be available in a listen-only mode on the company's website, which is located at . Participants who want to access the webcast should visit the company's website about five minutes before the call. The archived webcast will be available for replay on the company's website after the call. Constellation Brands, Inc. (NYSE: STZ), a leading beverage alcohol company, recently reported its first quarter fiscal 2023 financial results. A conference call to discuss the financial results and outlook was hosted by President and Chief Executive Officer, Bill Newlands, and Chief Financial Officer, Garth Hankinson, on Thursday, June 30, 2022 at 10:30 a.m. EDT. Anheuser-Busch InBev (NYSE: BUD) recently via Corona, an AB InBev global brand, announced the launch of Corona Tropical, the brand's first lightly sparkling alcoholic drink made with a hint of real fruit juice* available worldwide. An inclusive beverage for consumers who embrace the Corona lifestyle but are looking for an alternative to beer, Corona Tropical is a highly refreshing new way to enjoy Corona. The newest innovation by Corona is currently rolling out globally in China, Colombia, Peru, Panama, Ecuador and the UK, with additional markets launching later this year, starting with Canada. According to Research and Markets, the global alcoholic infused sparkling water market size is expected to expand at a compound annual growth rate of 12% over the next several years. As more consumers around the globe look for alternative, low-calorie beverages, Corona created a product catered to consumers searching for that Corona lifestyle, beyond beer. Corona Tropical is a refreshing alcoholic beverage with no added sugar and less than 100 calories per can, available in several tropical flavors. With Corona Tropical, Corona is expanding its global beverage portfolio to offer a new, refreshing, and flavorful taste of paradise, by developing a completely unknown category in some markets around the globe. DISCLAIMER: FN Media Group LLC (FNM), which owns and operates Financialnewsmedia.com and MarketNewsUpdates.com, is a third party publisher and news dissemination service provider, which disseminates electronic information through multiple online media channels. FNM is NOT affiliated in any manner with any company mentioned herein. FNM and its affiliated companies are a news dissemination solutions provider and are NOT a registered broker/dealer/analyst/adviser, holds no investment licenses and may NOT sell, offer to sell or offer to buy any security. FNM's market updates, news alerts and corporate profiles are NOT a solicitation or recommendation to buy, sell or hold securities. The material in this release is intended to be strictly informational and is NEVER to be construed or interpreted as research material. All readers are strongly urged to perform research and due diligence on their own and consult a licensed financial professional before considering any level of investing in stocks. All material included herein is republished content and details which were previously disseminated by the companies mentioned in this release. FNM is not liable for any investment decisions by its readers or subscribers. Investors are cautioned that they may lose all or a portion of their investment when investing in stocks. For current services performed FNM was compensated twenty five hundred dollars for news coverage of the current press releases issued by Splash Beverage Group, Inc.by a non-affiliated third party. FNM HOLDS NO SHARES OF ANY COMPANY NAMED IN THIS RELEASE. This release contains "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E the Securities Exchange Act of 1934, as amended and such forward-looking statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. "Forward-looking statements" describe future expectations, plans, results, or strategies and are generally preceded by words such as "may", "future", "plan" or "planned", "will" or "should", "expected," "anticipates", "draft", "eventually" or "projected". You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause future circumstances, events, or results to differ materially from those projected in the forward-looking statements, including the risks that actual results may differ materially from those projected in the forward-looking statements as a result of various factors, and other risks identified in a company's annual report on Form 10-K or 10-KSB and other filings made by such company with the Securities and Exchange Commission. You should consider these factors in evaluating the forward-looking statements included herein, and not place undue reliance on such statements. The forward-looking statements in this release are made as of the date hereof and FNM undertakes no obligation to update such statements. Contact Information: Media Contact email: [email protected] +1(561)325-8757 SOURCE FinancialNewsMedia.com

Financial StatementAcquisition

100 Deals associated with Taurine

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KEGG	Wiki	ATC	Drug Bank
D00047	Taurine	V06D	DB01956

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Dietary Supplement	-	-	-

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ARVO2023	Not Applicable	Glaucoma	-	Liposomal formulation with brimonidine, ribitol, and taurine	(jodypmfxkp) = xeryhhpnoa remhdeydae (imopdrvgxs ) View more	-	23 Apr 2023
				Liposomal formulation with brimonidine, ribitol, taurine, and HPMC	(jodypmfxkp) = cheqsfcown remhdeydae (imopdrvgxs ) View more
IRCT20200312046755N1 (Pubmed)	Phase 3	Emergence Delirium	-	Taurine supplementation	vsbyxbhhmz(japnzhwgqm) = vgcsbyhzib vkntfcrxsi (kauhupervm )	Positive	07 Aug 2022
				taurine (Placebo)	vsbyxbhhmz(japnzhwgqm) = teoatxmfmq vkntfcrxsi (kauhupervm )
ESC2021	Not Applicable	Cardiotoxicity	-	Doxorubicin	ecsgafwpwa(dzlgigsfki) = vvstomijcj ttiiqqvrew (ibbwtzbljs )	-	23 Apr 2021
				Taurine	ecsgafwpwa(dzlgigsfki) = tkkjvqvjse ttiiqqvrew (ibbwtzbljs )
NCT01192828 (CTgov)	Phase 1/2	Homocystinuria	15	Taurine (Taurine Intervention Group)	mfrshzmrbf(pfgqhujcuh) = pigckplavm cyugaresub (qffoogeoey, jwcdmvpzsu - pdzkrckwac) View more	-	09 Jul 2018
				Taurine (Taurine Intervention)	jgestndtyg(qvztpfvjup) = wheiaglwsi qyhhdbsjjl (yeohhudmwy, fqxiswlvuf - cvdetmwhsy) View more
ARVO2017	Not Applicable	Retinal Diseases	-	Taurine	oevtbwreqx(fdtphomqlb) = twfaqbpcvo rwebddfssf (ztqejjmwqa, 0.05)	-	07 May 2017
				Control (no taurine supplement)	oevtbwreqx(fdtphomqlb) = vtxjybmmrf rwebddfssf (ztqejjmwqa, 0.09)
NCT00420823 (Pubmed \| J Clin Psychiatry)	Phase 2	Psychotic Disorders	121	Taurine 4 g	(fdgbyrtqpe): P-Value = 0.004 View more	Positive	01 Dec 2016
				Placebo
ARVO2012	Not Applicable	-	-	Taurine	(rbxyofwwmk) = gyigmqrrzc stkhuigrig (nimuhhrszo )	-	01 Mar 2012
				GABA B receptor agonists	(rbxyofwwmk) = dhamblfajs stkhuigrig (nimuhhrszo )

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