Drug Type Small molecule drug |
Synonyms 2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H-pyrazolo[4,3-C]pyridine-3,6(2H,5H)-dione, GKT 831, GKT-01 + [3] |
Target |
Mechanism NOX1 inhibitors(NADPH oxidase 1 inhibitors), NOX4 inhibitors(NADPH oxidase 4 inhibitors) |
Therapeutic Areas |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 3 |
First Approval Date- |
RegulationFast Track (US), Orphan Drug (US), Orphan Drug (EU) |
Molecular FormulaC21H19ClN4O2 |
InChIKeyRGYQPQARIQKJKH-UHFFFAOYSA-N |
CAS Registry1218942-37-0 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Recurrent Squamous Cell Carcinoma of the Head and Neck | Phase 3 | SE | 30 Jan 2022 | |
Nephritis, Hereditary | Phase 2 | CZ | 27 Nov 2023 | |
Nephritis, Hereditary | Phase 2 | ES | 27 Nov 2023 | |
Nephritis, Hereditary | Phase 2 | GB | 27 Nov 2023 | |
Squamous cell carcinoma of head and neck metastatic | Phase 2 | US | 06 Apr 2022 | |
Squamous cell carcinoma of head and neck metastatic | Phase 2 | FR | 06 Apr 2022 | |
Squamous cell carcinoma of head and neck metastatic | Phase 2 | DE | 06 Apr 2022 | |
Squamous cell carcinoma of head and neck metastatic | Phase 2 | IT | 06 Apr 2022 | |
Squamous cell carcinoma of head and neck metastatic | Phase 2 | PL | 06 Apr 2022 | |
Squamous cell carcinoma of head and neck metastatic | Phase 2 | ES | 06 Apr 2022 |
NCT05323656 (PRNewswire) Manual | Phase 2 | 55 | ohfukfhcbx(jeyidxvwjq) = zwvzitjdgc pajmfqepht (brrhulctwz ) View more | Positive | 06 May 2024 | ||
Pembrolizumab + Placebo | ohfukfhcbx(jeyidxvwjq) = twzkpnsdpb pajmfqepht (brrhulctwz ) View more | ||||||
Phase 2 | Primary Biliary Cholangitis Second line | 111 | ruptcfwinc(dyavskyxij) = ptdlxptbud yvjofaszmk (lfjelllyqw, 59.6) View more | Positive | 15 May 2023 | ||
ruptcfwinc(dyavskyxij) = tevmdwcguc yvjofaszmk (lfjelllyqw, 28.9) View more | |||||||
Phase 2 | 111 | Placebo oral capsule+GKT137831 (GKT137831 400mg Once Daily) | olegdmvkhf(xfbvafomng) = duqzypjrhx fpfatkdxmj (oktaiatjdm, oeqactbxsw - slmngmsjkq) View more | - | 31 Mar 2022 | ||
(GKT137831 400mg Twice Daily) | olegdmvkhf(xfbvafomng) = eulkudyuvg fpfatkdxmj (oktaiatjdm, uizzwgltdc - kjzevetina) View more | ||||||
Phase 2 | 111 | wqeumjtzkv(nbbchvrthx): P-Value = <0.002 View more | Positive | 24 Jun 2019 | |||
Placebo | |||||||
BusinessWire Manual | Phase 2 | 155 | xnxfwqxgsn(nvnzfqmlrx) = not achieved within this timeframe toynhgqwol (uctncyxlmj ) View more | Positive | 09 Sep 2015 | ||
Placebo |