Observational data have suggested no increased risk of adverse pregnancy outcomes associated with exposure to interferon-beta (IFNB) before or during pregnancy. After the emergence of these data, the European Medicines Agency approved a label change for IFNB in September 2019, stating that use of IFNB during pregnancy may be considered, if clinically needed. However, limited data on pregnancies exposed in the 2nd and 3rd trimesters were observed.
INFORM is a secondary use of data drug utilisation study (DUS) to determine late pregnancy exposure (i.e. during the 2nd and 3rd trimester) to IFNB in Finland and Sweden, which will inform whether the number of exposed pregnancies is adequate to conduct a cohort study on adverse pregnancy outcomes, with a focus on late pregnancy exposure.
The number of pregnancies will be initially reported three years after the revised label implementation (September 2019) and will include data on pregnancies from 1996 in Finland and from 2005 in Sweden up through 31 December 2022. If the number of pregnancies is deemed adequate for conducting the cohort study on adverse pregnancy outcomes, this DUS will be finalised with the drug utilisation data accrued up through 31 December 2022. If the number of pregnancies until 31 December 2022 is deemed inadequate, this study may be continued and the primary and secondary objectives may be examined five years after the revised label implementation, including pregnancies until 31 December 2024.

Start Date20 Mar 2024

Sponsor / Collaborator

Bayer AG

[+3]

NCT04079088 / WithdrawnPhase 2

A Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Ranging Phase 2 Study to Evaluate the Efficacy and Safety of Oral BIIB061 as Add-On Therapy to Interferon-Beta 1 or Glatiramer Acetate Therapies in Relapsing Multiple Sclerosis

The primary objectives of the study are to evaluate the safety of BIIB061 versus placebo in participants with Relapsing Multiple Sclerosis (RMS), and to evaluate the efficacy of BIIB061 to improve disability outcome versus placebo in participants with RMS.
The secondary objectives of the study are to evaluate the effects of BIIB061 versus placebo on brain magnetic resonance imaging (MRI) markers of remyelination and axon preservation in chronic Multiple Sclerosis lesions and to evaluate the effects of BIIB061 versus placebo on additional measures of improved disability outcome.

Start Date30 Jun 2021

Sponsor / Collaborator

Biogen, Inc.

EUCTR2020-000620-18-FR / Not yet recruitingPhase 2IIT

Human recombinant interferon gamma-1b for the prevention of hospital-acquired pneumonia in critically ill patients: a double-blind, international phase 2, randomized, placebo-controlled trial - the PREV-HAP study - PREV-HAP

Start Date19 Feb 2021

Sponsor / Collaborator

Nantes University Hospital

100 Clinical Results associated with Interferon Beta-1b

100 Translational Medicine associated with Interferon Beta-1b

100 Patents (Medical) associated with Interferon Beta-1b

1,204

Literatures (Medical) associated with Interferon Beta-1b

15 Apr 2024·Internal medicine (Tokyo, Japan)

Thrombotic Microangiopathy after a 15-year Treatment with Interferon Beta-1b in a Patient with Multiple Sclerosis: A Case Report and Review of Literature

Review

Author: Akita, Satori ; Kajinami, Kouji ; Fujibayashi, Kosuke ; Kawai, Yasuyuki ; Wakasa, Minoru ; Ueno, Ei-Ichi

A 54-year-old woman with multiple sclerosis treated with interferon-β (IFN-β)-1b for 15 years presented with sustained hypertension (240/124 mmHg) and retinal bleeding. She had proteinuria, anemia, thrombocytopenia, elevated serum creatinine levels, and haptoglobin depletion. Intravenous nicardipine stabilized her blood pressure, but her renal function and platelet count deteriorated. The initial disintegrin-like metalloprotease with thrombospondin type 1 motifs 13 (ADAMTS13) activity was 28% of normal without its inhibitor. The subsequent peripheral appearance of schistocytes suggested thrombotic microangiopathy (TMA). After IFN-β-1b cessation, the platelet count increased, and the blood pressure stabilized. The ADAMTS13 activity normalized, although the creatinine level did not. TMA may develop after the long-term use of IFN-β without adverse events.

01 Jul 2023·Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

Quantitative comparison of the efficacy of clinical drug treatments for primary progressive multiple sclerosis

Article

Author: Sui, Zichao ; Zhu, Haoxiang ; Yu, Jiesen ; Luo, Jieren ; Zheng, Qingshan ; Li, Lujin

OBJECTIVE:

This study proposes a comprehensive quantitative evaluation of the efficacy of drugs and placebo in clinical trials for primary progressive multiple sclerosis (PPMS).

METHODS:

A literature search was conducted using the PubMed, EMBASE, and Cochrane library databases and the clinical studies reporting drug efficacy in the treatment of PPMS were included in the analyses. The cumulative proportion of patients without confirmed disability progression (wCDP%) was used as the main efficacy endpoint. The model-based meta-analysis method was used to describe the time course of each drug (as well as placebo) in order to rank the drug efficacy for the treatment of PPMS.

RESULTS:

Fifteen studies involving 3779 patients were included, of which, nine were placebo-controlled and six were single-arm trials. Twelve drugs were included in the study. The results showed that, except for biotin, interferon β-1a, and interferon β-1b, whose efficacy was comparable to the placebo, the efficacy of the other 9 drugs were significantly better than placebo. Among these, ocrelizumab showed outstanding performance, with wCDP% of 72.6 at 96 weeks, while the proportions of rest of the drugs ranged between approximately 55-70%.

CONCLUSION:

The results of this study provide the necessary quantitative information for both the rational clinical use of drugs and future clinical trials in primary progressive multiple sclerosis.

01 Jun 2024·CNS & neurological disorders drug targets

The Peripheral Profile of the Chitinase 3-like-1 in Benign Multiple Sclerosis – A Single Centre’s Experience

Article

Author: Andone, Sebastian ; Barcutean, Laura ; Hutanu, Adina ; Balasa, Rodica ; Maier, Smaranda

Background::

A limited subgroup of multiple sclerosis (MS) patients present with a longterm disease evolution characterized by a limited disease progression, known as benign MS (BMS). Chitinase 3-like-1 (CHI3L1) levels are sensitive to inflammatory processes and may play a role in the pathogenesis of MS. In this observational, cross-sectional study, we aimed to evaluate the implications of serum CHI3L1 and inflammatory cytokines in BMS patients treated with interferon β-1b for over a decade.

Methods::

We collected serum samples from 17 BMS patients and 17 healthy controls (HC) to measure serum CHI3L1 levels and a Th17 panel of inflammatory cytokines. Serum levels of CHI3L1 were analysed using the sandwich ELISA method and the Th17 panel was assessed using the multiplex XMap technology on a Flexmap 3D Analyzer.

Results::

Serum CHI3L1 levels did not differ significantly from HC. We identified a positive correlation between CHI3L1 levels and relapses during treatment.

Conclusions::

Our findings suggest that there are no differences in serum CHI3L1 levels between BMS patients and HC. However, serum CHI3L1 levels are sensitive to clinical inflammatory activity and may be associated with relapses in BMS patients.

News (Medical) associated with Interferon Beta-1b

18 Sep 2023

·www.biospace.com

Atriva Therapeutics Announces Exclusive Letter Agreement for Reverse Takeover Transaction with Biocure Technology

Atriva Therapeutics and Canadian Biocure Technologies, Inc. entered into an exclusive letter agreement for a reverse takeover transaction. Upon successful completion of the transaction, the resulting entity will continue the business of Atriva Therapeutics. Shareholders of Atriva will receive not less than 75% of the securities of the resulting issuer, with the current shareholders of Biocure Technology holding the remainder. The transaction is subject to various terms and conditions, including satisfactory due diligence, successful implementation of a private placement and shareholder approvals. TÜBINGEN, Germany and MUNICH, Germany, Sept. 18, 2023 (GLOBE NEWSWIRE) -- Atriva Therapeutics GmbH (“Atriva”) is pleased to disclose the signing of an exclusive letter agreement, dated September 14, 2023, with Biocure Technology Inc. (“CURE”) (CSE: CURE), based in Vancouver, Canada. This agreement marks a significant step forward in Atriva’s commitment to combating severe RNA virus infections through innovative host-cell-targeting therapies. “We are delighted to have entered into this exclusive letter agreement with Biocure. Our discussions with the Biocure management and board of directors have been exceptionally productive and constructive. We are eager to embark on this journey and combine the strengths of both companies. Together, we aim to address the urgent medical need for safe and effective therapies for patients suffering from severe RNA virus infections. This agreement marks a significant milestone in our commitment to advancing innovative solutions for the benefit of global healthcare,” said Christian Pangratz, Chief Executive Officer of Atriva. “This letter agreement underscores our commitment to leverage this transaction with CURE as an attractive growth option for Atriva and its stakeholders. We are enthusiastic about the prospect of our companies joining forces and continuing to contribute to improving pandemic preparedness on an extended international scale,” stated Ulrich Dauer, PhD, Chairman of the Advisory Board of Atriva. Highlights of the Transaction: Upon transaction completion, Atriva shareholders and concurrent financing subscribers will collectively hold not less than 75% of the securities of the resulting issuer. Current CURE shareholders will retain a maximum of 25% on a fully diluted basis. The letter agreement stipulates no advances from CURE to Atriva. Atriva will provide CURE with an exclusivity fee of CA$15,000 per month for a minimum of three months. Additionally, a finder's fee of US$2,000,000 is payable through the issuance of CURE shares, with pricing to be determined, aligning with concurrent private placement terms. Transaction Conditions: The completion of the Transaction is contingent upon various terms and conditions, including the successful completion of due diligence, the execution of a definitive agreement by November 30, 2023, (inclusive of typical transaction elements), and the successful completion of a private placement by Atriva or CURE to raise gross proceeds of at least US$15,000,000. Additionally, approval from both companies' shareholders and the endorsement of the CSE and other relevant regulatory authorities are essential prerequisites for finalization. For additional information on this transaction, please visit . About Atriva Therapeutics Atriva Therapeutics’ mission is to develop an antiviral therapy platform against severe respiratory and systemic diseases with a high unmet medical need induced by RNA viruses, e.g., influenza and COVID-19. The clinical-stage biopharmaceutical company is pioneering the development of host-targeting antiviral therapies, making development of viral resistance unlikely, and thereby significantly contributing to pandemic preparedness. The Atriva lead product zapnometinib (ATR-002) is a first-in-class, host-targeting agent that aims to inhibit viral replication and to favorably modulate the body’s immune response to RNA viruses. Atriva Therapeutics was founded in 2015 in Tübingen by a team of leading scientists in viral research and seasoned industry experts and is based with its administrative/operations office in Martinsried (near Munich), Germany. For further information, please visit and follow us on LinkedIn and X (formerly Twitter). About Biocure Biocure owns approximately 45% stakes of BiocurePharm in Korea who is a leading biotech company developing its CAR-T cell therapy for leukemia, lung, breast and pancreatic cancer. BiocurePharm is in the process of pre-clinical trials of three major biosimilar products in South Korea, including Interferon Beta 1b, PEG- Filgrastim as well as Ranibizumab. Interferon Beta 1b is used for treating relapsing forms of multiple sclerosis (“MS”). Filgrastim is used to treat neutropenia, a lack of certain white blood cells caused by bone marrow transplants, chemotherapy, and other conditions. Ranibizumab is used for treating macular degeneration. It is also used to treat a type of eye problem known as macular edema, as well as certain eye problems caused by diabetes. Contact: Atriva Therapeutics GmbH Christian Pangratz, CEO Phone: +49 69 9999 162 10 pangratz@atriva-therapeutics.com

ImmunotherapyCell Therapy

02 Aug 2022

·endpts.com

Granfluencers and boomfluencers: Is the hipster oldster social media trend moving to pharma?

Cathy Chester’s latest Instagram post is about her experience being pregnant while having multiple sclerosis — in 1992. That was six years after her initial diagnosis and one year before Betaseron became the first FDA-approved drug to treat the underlying disease in relapsing-remitting MS. Chester, now 63, writes about how a few years before she became pregnant, when she was considering getting married, she drove more than 90 minutes to hear a specialist talk about MS and pregnancy. Because the internet was still emerging then, and modern smartphones were only a twinkle in Apple’s eye, she couldn’t just “look it up.” And her doctors back then weren’t as open to listening to patients’ personal issues as they are today.

10 Jun 2021

·www.globenewswire.com

Multiple Sclerosis Drugs Market to Reach USD 41.99 Billion by 2028; Rising Support from Governments and Launch of Awareness Initiatives to Aid Growth: Fortune Business Insights™

Pune, India, June 10, 2021 (GLOBE NEWSWIRE) -- The global multiple sclerosis drugs market size is set to gain traction as many leading pharmaceutical companies are conducting clinical trials to discover innovative and effective therapies for the treatment of this immune disorder. For instance, in December 2020, Adamas Pharmaceuticals, Inc. declared the results of its phase 3 clinical trials on ADS-5102, for the treatment of multiple sclerosis (MS) patients. This information is given by Fortune Business Insights™ in a published report, titled, “Multiple Sclerosis Drugs Market, 2021-2028.” As per the report, the market size was USD 26.05 billion in 2020 and is projected to reach USD 41.99 billion by 2028, exhibiting a CAGR of 6.3 % during the forecast period. COVID-19 Pandemic: Disruptions in Supply Chain and Production Delays to Hinder Growth The outbreak of the COVID-19 pandemic has severely affected the multiple sclerosis drugs market growth as it has caused some disruption in the supply chain of several major players operating in the multiple sclerosis drugs industry. For example, Biogen reported that one of its major drugs named TECFIDERA used for the treatment of multiple sclerosis witnessed a decline of 13% in 2020 as compared to the previous year. This decline was seen as a DMT based approach for the treatment of MS that has an adverse effect on COVID-19 patients. These factors are expected to moderately impact the market growth. Request a Sample Copy of Research Report: Industry Developments August 2020 - Novartis launched its U.S. Food and Drug Administration (FDA) has approved subcutaneous injection Kesimpta (ofatumumab), for the treatment of relapsing forms of multiple sclerosis (RMS). January 2020 - Bristol Myers Squibb launched Zeposia. This drug is one of the economical drugs available in the market for MS patients. Report Coverage- The report aims to analyze the multiple sclerosis drugs industry by considering contributions, prospects, and growth trends. It presents detailed profiles of every key player operating in the market to analyze their core competencies in each segment. Apart from that, it ensures to help our clients better understand the competitive developments, such as mergers & acquisitions, new product launches, joint ventures, and collaborations. To get to know more about the short-term and long-term impact of COVID-19 on this market, please visit: Immunomodulators to Dominate the Market Owing to New Drug Launches By drug class, the market is divided into immunomodulators, immunosuppressants, interferons, and others. Out of these, immunomodulators dominated the market in 2020 owing to new drug launches such as Mayzent. On the other hand, immunosuppressants are also expected to see a substantial rise as the drug MAVENCLAD is characterized with long-term efficacy for the treatment of MS. Proactive Measures Taken by Governments to Strengthen the Market Growth As the prevalence of MS is increasing at an alarming rate, governments are aiding the market by campaigning about different treatment options available. In June 2018, for instance, the National Institute of Health and Care Excellence (NICE) announced recommendations for the use of beta interferons such as Avonex, Betaferon, Extavia, Rebif. These steps taken by government agencies will fuel the market in the upcoming years. Despite government interference, the cost of drugs for multiple sclerosis remains a major challenge for the growth of the market. From 2013 to 2018, the price was increased by more than US$ 20,000. Thus, increased prices of the drugs will add to the economic burden owing to the rise of out-of-pocket expenses. Quick Buy Multiple Sclerosis Drugs Market Research Report: List of Key Players Covered in the Multiple Sclerosis Drugs Market Report: Have Any Query? Ask Our Experts: Detailed Table of Content: TOC Continued…..!!!! Get your Customized Research Report: Have a Look at Related Reports: Telehealth Market Size, Share and Global Trend By Type (Products, Services), By Application (Telemedicine, Patient Monitoring, Continuous Medical Education, Others), By Modality (Store-and-forward (Asynchronous), Real-time (Synchronous), Remote Patient Monitoring), By End User (Healthcare Facilities, Homecare, Others), and Geography Forecast till 2026 Contraceptive Drugs Market Size, Share and Global Trend By Product Type (Oral, Injectable, Patches), Distribution Channel (Hospital Pharmacy, Retail Pharmacy, Clinics, Online Channel, Public Channel & NGOs) and Geography Forecast till 2025 Hereditary Angioedema Treatment Market Size, Share and Global Trend by Drug Class (C-1 Esterase Inhibitors, Bradykynin Receptor Antagonist, Kallikrein Inhibitors), Application (Prophylaxis, Treatment), Route of Administration (IV, Subcutaneous), Distribution Channel (Hospital Pharmacy, Retail Pharmacy) and Geography Forecast till 2025 Thrombin Market Size, Share and Global Trend By Product (Bovine Thrombin, Human Thrombin, Recombinant Thrombin), By Dosage Form (Powder Form, Solution Form), By End user (Hospitals, Diagnostics Centers & Clinics, Academics and Research Institutes), and Geography Forecast till 2025 About Us: Fortune Business Insights™ offers expert corporate analysis and accurate data, helping organizations of all sizes make timely decisions. We tailor innovative solutions for our clients, assisting them to address challenges distinct to their businesses. Our goal is to empower our clients with holistic market intelligence, giving a granular overview of the market they are operating in. Our reports contain a unique mix of tangible insights and qualitative analysis to help companies achieve sustainable growth. Our team of experienced analysts and consultants use industry-leading research tools and techniques to compile comprehensive market studies, interspersed with relevant data. At Fortune Business Insights™ we aim at highlighting the most lucrative growth opportunities for our clients. We, therefore, offer recommendations, making it easier for them to navigate through technological and market-related changes. Our consulting services are designed to help organizations identify hidden opportunities and understand prevailing competitive challenges. Contact Us: Fortune Business Insights™ Pvt. Ltd. 308, Supreme Headquarters, Survey No. 36, Baner, Pune-Bangalore Highway, Pune - 411045, Maharashtra, India. Phone:US :+1 424 253 0390UK : +44 2071 939123APAC : +91 744 740 1245Email: sales@fortunebusinessinsights.comFortune Business Insights™LinkedIn | Twitter | Blogs Press:

AcquisitionCollaborate

100 Deals associated with Interferon Beta-1b

External Link

KEGG	Wiki	ATC	Drug Bank
D00746	Interferon Beta-1b	L03AB08	DB00068

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
RRMS	EU	Bayer AG	30 Nov 1995
RRMS	IS	Bayer AG	30 Nov 1995
RRMS	LI	Bayer AG	30 Nov 1995
RRMS	NO	Bayer AG	30 Nov 1995
Multiple Sclerosis, Secondary Progressive	EU	Bayer AG	30 Nov 1995
Multiple Sclerosis, Secondary Progressive	IS	Bayer AG	30 Nov 1995
Multiple Sclerosis, Secondary Progressive	LI	Bayer AG	30 Nov 1995
Multiple Sclerosis, Secondary Progressive	NO	Bayer AG	30 Nov 1995
Multiple Sclerosis	US	Bayer HealthCare Pharmaceuticals, Inc.	23 Jul 1993

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Multiple sclerosis relapse	Phase 3	US	Bayer AG	01 May 2007
Multiple sclerosis relapse	Phase 3	AR	Bayer AG	01 May 2007
Multiple sclerosis relapse	Phase 3	AU	Bayer AG	01 May 2007
Multiple sclerosis relapse	Phase 3	AT	Bayer AG	01 May 2007
Multiple sclerosis relapse	Phase 3	BE	Bayer AG	01 May 2007
Multiple sclerosis relapse	Phase 3	BR	Bayer AG	01 May 2007
Multiple sclerosis relapse	Phase 3	CA	Bayer AG	01 May 2007
Multiple sclerosis relapse	Phase 3	DK	Bayer AG	01 May 2007
Multiple sclerosis relapse	Phase 3	FI	Bayer AG	01 May 2007
Multiple sclerosis relapse	Phase 3	FR	Bayer AG	01 May 2007

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ECTRIMS2022	Not Applicable	RRMS	140	Actoferon®	mjdlyoedba(fuanhilknh) = gaejtvixsp zhzhkaleaq (jvhxuubxsj ) View more	Positive	12 Oct 2022
				Betaferon®	mjdlyoedba(fuanhilknh) = ovkgrbezvf zhzhkaleaq (jvhxuubxsj ) View more
Pubmed	Phase 2	COVID-19	-	Interferon beta-1b + Remdesivir	zcmmypctud(raujmbdgkw) = hwijianvod nuqguxkcad (xifvwfameh ) View more	Positive	28 Jun 2022
				Remdesivir	zcmmypctud(raujmbdgkw) = siqfqentrq nuqguxkcad (xifvwfameh ) View more
NCT00176592 (BECOME, CTgov)	Phase 4	Multiple Sclerosis	75	Betaseron (Betaseron)	cbqmbpuxfs(pfrnovmvux) = wyhgymknzt wrjxrsrjlq (rvnvrdilis, tvsdccqeiy - cbgzojuwji) View more	-	16 Nov 2021
				Copaxone (Copaxone)	cbqmbpuxfs(pfrnovmvux) = arulwrqlaz wrjxrsrjlq (rvnvrdilis, uudlygwetb - rlvvfgmcsj) View more
NCT00787657 (Pubmed \| BMC Neurol)	Not Applicable	Multiple Sclerosis	481	interferon beta-1b (41-50 years)	ixmybqrqvo(xxndwhxygj) = The percentage of patients with anxiety and depression, as measured by HADS, were stable over the study period zyvobnxwvs (dxyfewcldh )	-	23 Aug 2021
				interferon beta-1b (> 50 years)
ECTRIMS2020	Not Applicable	COVID-19 SARS-CoV-2	109	IFN β-1b	bkwhrgmltu(dsmkpswpva) = ipbrxpldse rnnwwkjorp (gldhngtcxo ) View more	-	07 Dec 2020
NCT03134573 (Pubmed \| J Med Internet Res)	Not Applicable	Multiple Sclerosis	96	Interferon Beta-1b (Patients using myBETAapp)	wmjrzarwxg(jxkobjopyp) = irirnsbiyl ynfdwtdawc (ceekxpdbar ) View more	-	29 Jul 2019
BENEFIT 15 (ACTRIMS2019)	Not Applicable	MRI lesions	468	Interferon beta-1b (early treatment)	feybmnbcel(kskhtolpxr) = mean 2.5 (1.76); median 2.0 (1.5, 3.5) (EDSS 0-2.5: 162 patients [62.1%], 3.0-5.5: 80 [30.7%], 6.0-6.5: 12 [4.6%], >=7: 7 [2.7%]) gjdxpqveiz (dajsyvthyw ) View more	Positive	07 May 2019
				Placebo+Interferon beta-1b (delayed treatment)
AAN2019	Not Applicable	Pregnancy	2,571	Interferon beta-1b	crftuljhpg(cyuhnpwohd) = bwpoizolbf cpvhwztyvj (lzuhmmytqe ) View more	-	09 Apr 2019
BENEFIT 15 (AAN2019)	Phase 3	Carcinoma in situ of uterine cervix	468	Interferon beta-1b (early treatment)	kjwkoiyyfx(kjwgqdbeqi) = 0.2083 overall over 15 years zfhnuyjate (rgumbotxau ) View more	Positive	09 Apr 2019
BENEFIT 15 (ECTRIMS2018)	Not Applicable	Carcinoma in situ of uterine cervix	468	Interferon beta-1b (early treatment)	wxmixxzfhl(tdiizgidfd) = mcensipvgc rjoobdgjxd (dohtjebuzd )	-	09 Oct 2018

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