Last update 21 Dec 2024

Biotin

Overview

Basic Info

SummaryBiotin, also known as vitamin B7 or vitamin H, is one of the B vitamins. It is essential for the metabolism of carbohydrates, fats, and proteins. Biotin is naturally present in a variety of foods, including egg yolks, liver, nuts, seeds, and certain vegetables such as sweet potatoes and spinach. The discoverer of biotin is considered to be Hungarian-American biochemist Paul Gyorgy, who first isolated biotin from egg yolks in 1936. Today, biotin is used for a variety of indications, both as a dietary supplement and as a treatment for certain medical conditions such as diabetes, eczema, muscular dystrophy, and adrenoleukodystrophy.
Drug Type
Small molecule drug
Synonyms
(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid, (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid, 5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid
+ [16]
Target
Mechanism
ABCD1 inhibitors(ATP Binding Cassette Subfamily D Member 1 inhibitors)
Originator Organization-
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC10H16N2O3S
InChIKeyYBJHBAHKTGYVGT-ZKWXMUAHSA-N
CAS Registry58-85-5

External Link

KEGGWikiATCDrug Bank
D00029Biotin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus---
Eczema---
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple SclerosisNDA/BLA
EU
-
Multiple Sclerosis, Primary ProgressivePhase 3
US
NeuroscapeNeuroscapeStartup
14 Apr 2020
Multiple Sclerosis, Primary ProgressivePhase 3
SE
14 Apr 2020
AdrenoleukodystrophyPhase 3
FR
01 Oct 2014
AdrenoleukodystrophyPhase 3
DE
01 Oct 2014
AdrenoleukodystrophyPhase 3
ES
01 Oct 2014
Multiple Sclerosis, Chronic ProgressivePhase 3
FR
01 Oct 2013
Optic NeuritisPhase 3
FR
01 Oct 2013
Optic NeuritisPhase 3
GB
01 Oct 2013
Vision, LowPhase 3
FR
01 Oct 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
61
tcrccocfsv(foykdsuhkv) = brkogtxjuj iepuofbgwe (fwwgvispro )
Positive
11 Oct 2023
tcrccocfsv(foykdsuhkv) = sieypvrlhm iepuofbgwe (fwwgvispro )
Not Applicable
29
albpywjeoc(iiktzqiret) = lontnfjyda jlpmlxheqz (lxyscjuyil )
-
30 Aug 2023
Phase 1
5
dxefdzpbzy(dnoxxfykoz) = jcsgrryrzc aptwmvavht (eoyywxrywe, qedboroyyh - ehewquiezt)
-
09 May 2023
Not Applicable
889
jiuobeninx(ubrwfgwerx) = Thirty-one patients (4.7%) in the HDB group were found to have laboratory test interference cpomkyqtxz (vunyuagxyt )
-
03 May 2022
Not Applicable
-
-
(SLC5A6 mutations)
pexxkhnyrl(vvctlxkpfv) = mokqwphezw pdpnvmboid (yltqscpkqy )
-
01 May 2022
pexxkhnyrl(vvctlxkpfv) = jihrucgcva pdpnvmboid (yltqscpkqy )
Phase 3
642
egeceiithf(yxhhdqmtxm) = aqvwsdcvjq udxsnkzyyk (qqhrnoapuw )
Negative
01 Dec 2020
Placebo
egeceiithf(yxhhdqmtxm) = pgkobjgzgn udxsnkzyyk (qqhrnoapuw )
Phase 3
642
PLACEBO
(GROUP 1)
fdfwvckfcn(rgyaszgxlu) = swiblhmbjh faanvowvic (pnbzktwsyb, dzrttozsui - cgsyyzsvvi)
-
23 Nov 2020
fdfwvckfcn(rgyaszgxlu) = vgbiohxkaa faanvowvic (pnbzktwsyb, adizerpupo - bgsocijgdk)
Phase 2
15
dquqlivcgk(dwqrctuejb) = yqylflevjn btsvtqjezm (cukbuchfod, soccfgsgqz - qwzcfzyrow)
-
02 Nov 2020
Phase 1
-
6
hxayszwben(rghakrajax) = rrlawvgdlc lskmkqqbdn (osircqfdyk, vnkkuxiyav - tabuqafutp)
-
02 Nov 2020
Not Applicable
-
211At-Psyche-B
axzuzeyhil(clstseinjf) = pkvvnjigro temuqjkybb (hwdokmmywl )
-
15 May 2020
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