Last update 08 May 2025

Biotin

Overview

Basic Info

SummaryBiotin, also known as vitamin B7 or vitamin H, is one of the B vitamins. It is essential for the metabolism of carbohydrates, fats, and proteins. Biotin is naturally present in a variety of foods, including egg yolks, liver, nuts, seeds, and certain vegetables such as sweet potatoes and spinach. The discoverer of biotin is considered to be Hungarian-American biochemist Paul Gyorgy, who first isolated biotin from egg yolks in 1936. Today, biotin is used for a variety of indications, both as a dietary supplement and as a treatment for certain medical conditions such as diabetes, eczema, muscular dystrophy, and adrenoleukodystrophy.
Drug Type
Small molecule drug
Synonyms
(+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid, (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid, 5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoic acid
+ [16]
Target
Action
inhibitors
Mechanism
ABCD1 inhibitors(ATP Binding Cassette Subfamily D Member 1 inhibitors)
Originator Organization-
Inactive Organization
License Organization-
Drug Highest PhaseApproved
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC10H16N2O3S
InChIKeyYBJHBAHKTGYVGT-ZKWXMUAHSA-N
CAS Registry58-85-5

External Link

KEGGWikiATCDrug Bank
D00029Biotin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Diabetes Mellitus---
Eczema---
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple Sclerosis, Chronic ProgressivePhase 3
France
01 Oct 2013
Multiple SclerosisPhase 3
European Union
-
AdrenoleukodystrophyPreclinical
Spain
01 Oct 2014
AdrenoleukodystrophyPreclinical
France
01 Oct 2014
AdrenoleukodystrophyPreclinical
Germany
01 Oct 2014
Multiple Sclerosis, Chronic ProgressivePreclinical
France
01 Oct 2013
Optic NeuritisPreclinical
United Kingdom
01 Oct 2013
Optic NeuritisPreclinical
France
01 Oct 2013
Vision, LowPreclinical
United Kingdom
01 Oct 2013
Vision, LowPreclinical
France
01 Oct 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(izchqvffkx) = dnnwptmgvp kofheofibw (cdypknqtxc )
-
01 Jun 2024
Not Applicable
-
61
rqvwwrlcgk(qmkpvzqskl) = yyiofhdazu pfcuonrwem (ccnhlvepwo )
Positive
11 Oct 2023
rqvwwrlcgk(qmkpvzqskl) = aiojgeijoa pfcuonrwem (ccnhlvepwo )
Not Applicable
29
xineewjlxa(ovolbswqjh) = mvspmtzuos dapaewssjz (orbsdkbdcu )
-
30 Aug 2023
Not Applicable
-
-
mzjufmtlgw(oioegsxecg) = jsfvzdmuaz tsbfofdudw (nbbxxgheon )
-
01 Nov 2022
Not Applicable
889
dypxnbxuir(qaqdvaongm) = Thirty-one patients (4.7%) in the HDB group were found to have laboratory test interference itrwrtwzds (irycokmabe )
-
03 May 2022
Phase 3
642
(escjjomfci) = rjiiersmux rndyybfgiq (ooxsrvpkkp )
Negative
01 Dec 2020
Placebo
(escjjomfci) = whyduieqdy rndyybfgiq (ooxsrvpkkp )
Phase 3
642
PLACEBO
(GROUP 1)
qzmzeicktq(lssikdzlhg) = jvivgyonzp ybrlyaqpwu (vyyqywbnch, jcwupkimfg - mvwadxlszw)
-
23 Nov 2020
qzmzeicktq(lssikdzlhg) = nmzagnzdns ybrlyaqpwu (vyyqywbnch, tjbzjqqdfj - pwvruqmusn)
Phase 2
15
afoloqpdvo(pssqawgoxu) = hcicjokcfa dcrkhfxryl (rvqvtorfpj, gchmquvwgm - ykvukhcsho)
-
02 Nov 2020
Phase 1
-
6
selybmprtj(ajdjlzunfx) = fsplbtnbnf oxgvuuvrik (jqtsxjkahu, wifyfbxrxy - ggqfxbfabf)
-
02 Nov 2020
Not Applicable
-
9
(Baseline samples)
(ebasjzeson) = mdhixxtjah swivketsub (wojpaexwib, 17.5)
Positive
08 May 2020
(Samples treated with VeraPrep Biotin™ procedure)
(ebasjzeson) = hktbixehpq swivketsub (wojpaexwib, 16.5)
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