Furazolidone

Antibiotics are crucial in modern medicine for combating bacterial illnesses and saving lives.Still, their overuse has led to the rise of antibiotic-resistant bacteria, creating a serious public health risk.This study offers a unique approach for synthesizing a SnO₂/MoO₃ composite via precipitation and integrating it with com. carbon black (CB) to make a SnO₂/MoO₃/CB composite.This substantially increases electrochem. detection, especially for antibiotics like furazolidone (FZD).The study uses multiple spectroscopic techniques to thoroughly characterize the SnO₂/MoO₃/CB composite, demonstrating its potential as an electrochem. sensor.We used a screen-printed carbon electrode (SPCE) to detect FZD.We found that the composite performed exceptionally well, with a detection limit of 0.01μM owing to the enhanced surface area of the proposed sensor related to other modified electrodes.The sensor demonstrated good sensitivity (4.125μA μM^-1 cm^-2) and selectivity and excellent real-time detection capability FZD in water samples, urine, and pharmaceutical samples.In these real-world samples, the SnO₂/MoO₃/CB@SPCE sensor also showed outstanding selectivity and recovery rates for FZD.This paper demonstrates a substantial advancement in the development of SnO₂/MoO₃/CB-SPCE sensors for antibiotic detection, with important implications for healthcare and environmental monitoring.

Antibiotics are emerging hazardous small molecules, requiring urgent need for fast signal-on analytical methods to control antibiotic abuse. Signal-on fluorescence sensing strategies utilizing nanoquenchers and aptamers are fascinating but rarely accomplished on paper-based platforms. Here, a novel multilayer MXene sensing platform was established by leveraging Nb₂C-MXene as a multilayer nanoquencher and zero-dimensional carbon dots-labeled aptamer (B-CDs@Apt) as a stable and bright recognition probe. The Nb₂C-MXene has a multilayer nanosheet stack-like structure and efficient mass transfer channels. It can efficiently adsorb abundant B-CDs@Apt probes and quench their fluorescence. Importantly, the Nb₂C-MXene/B-CDs@Apt system can release the B-CDs@Apt in response to the analyte with high sensitivity, thereby restoring the fluorescent signal. The developed aptasensor achieved sensitive and selective detection of chloramphenicol (CAP) and showed satisfactory anti-interference ability, stability, and practicability. Notably, the multilayer Nb₂C-MXene/B-CDs@Apt system was successfully transferred to a paper-based sensing platform, with a low-density distribution of multilayer nanoquenchers carrying sufficient aptamer probes for analyte access. In comparison, the monolayer Nb₂C nanosheets were unable to adsorb enough probes to output analyte-induced signals. The established paper-based analytical device (PAD) showed a LOD of 0.360 ng mL^-1 for CAP, which is the first paper-based MXene aptasensor reported for fluorescence detection. By replacing the aptamer and carbon dot, the strategy was further extended to detect another analyte oxytetracycline (OTC), with LODs of 0.399 in tube and 0.867 ng mL^-1 on PAD, respectively. Furthermore, concurrent detection of CAP and OTC was achieved using a dual-color PAD, demonstrating the potential to meet multi-target analytical requirements.