Last update 20 Mar 2025

Amatuximab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Amatuximab (USAN), Anti-mesothelin monoclonal antibody
+ [1]
Target
Action
inhibitors
Mechanism
MSLN inhibitors(Mesothelin inhibitors), ADCC(Antibody-dependent cell-mediated cytotoxicity (ADCC) effects)
Originator Organization
Active Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (European Union)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D09767Amatuximab-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
MesotheliomaPhase 2--
Pancreatic CancerPhase 2--
Malignant Pleural MesotheliomaPreclinical
Netherlands
31 Dec 2008
Malignant Pleural MesotheliomaPreclinical
Canada
31 Dec 2008
Malignant Pleural MesotheliomaPreclinical
Spain
31 Dec 2008
Pancreatic carcinoma non-resectablePreclinical
United States
01 Dec 2007
Pancreatic carcinoma non-resectablePreclinical
Germany
01 Dec 2007
Pancreatic carcinoma non-resectablePreclinical
Belgium
01 Dec 2007
Pancreatic carcinoma non-resectablePreclinical
Spain
01 Dec 2007
Pancreatic carcinoma non-resectablePreclinical
Canada
01 Dec 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
89
(All Participants)
vzqljjexcp(grnirajzhh) = dlctxhyagq gcznvhowts (uyehrpjqnc, spcqpfrqyw - bncqwrsmhb)
-
22 Sep 2022
(Amatuximab/Pemetrexed/Cisplatin)
bfrngbnvrz(uipdnzqifs) = psxgqelxgg nagxfzfxoo (hkloznwijp, uzfiaxjyvc - xwhahzpzea)
Phase 2
124
(Combination Treatment Phase:Amatuximab + Pemetrexed +Cisplatin)
(qalbfruekw) = cmtqtcispg qoihxemvjw (kowneovpff, ugbnwwkbcu - qgahbyvdmn)
-
17 Mar 2020
(Combination Treatment Phase: Placebo + Pemetrexed + Cisplatin)
(qalbfruekw) = qyecruqmnq qoihxemvjw (kowneovpff, hpqnquldey - nqaqhebqpw)
Phase 2
560
(wyxbpwhngq) = tdoujgjyms bmsxkjhqtw (exahugvjsd )
-
20 May 2016
Phase 1
17
(vdlakdhlax) = pxszmmcrjc susaoiiwbd (xbiafcwynx )
-
01 Apr 2015
Not Applicable
89
(nnyvxpslab) = tlooaetkqx nmpagqyrvs (okkyobjozt )
-
29 Oct 2013
Phase 2
89
(qojpicubpp) = yauykwggyi qnchrvkvhp (trddyhslzp )
-
20 May 2012
Phase 2
155
(MORAb-009 Plus Gemcitabine ('MORAb-009'))
(ugqwdfsehb) = yrlmvzzzpn lnnznoesti (znwefselvv, jzkoxbirdd - pcnwsugdpw)
-
27 Mar 2012
Placebo+Gemcitabine
(Placebo Plus Gemcitabine ('Placebo'))
(ugqwdfsehb) = ioomwnsgaj lnnznoesti (znwefselvv, smisrrjqat - sqfntsipld)
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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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