Last update 24 Mar 2025

Ningetinib Tosylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ct-053 free base, Ct-053-ptsa free base, Ct053ptsa free base
+ [4]
Action
inhibitors, antagonists
Mechanism
AXL inhibitors(AXL receptor tyrosine kinase inhibitors), FLT3 inhibitors(Tyrosine-protein kinase receptor FLT3 inhibitors), MerTK inhibitors(Tyrosine-protein kinase Mer inhibitors)
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC38H37FN4O8S
InChIKeyNAUYISNCVNUUDK-UHFFFAOYSA-N
CAS Registry1394820-77-9

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerPhase 2-27 Nov 2022
Advanced Hepatocellular CarcinomaPhase 2
China
07 Jun 2021
Metastatic Renal Cell CarcinomaPhase 2
China
25 Jun 2018
Renal Cell CarcinomaPhase 2
China
25 Jun 2018
EGFR T790M Mutation Positive Non-Small Cell Lung CarcinomaPhase 2
China
01 Nov 2016
Kidney NeoplasmsPhase 1
China
30 Jan 2022
LeukemiaPhase 1
China
30 Jan 2022
FLT3 positive Acute Myeloid LeukemiaPhase 1
China
13 Nov 2017
Relapsing acute myeloid leukemiaPhase 1
China
13 Nov 2017
Intestinal NeoplasmsPhase 1
China
08 Apr 2014
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
86
banzyvubjg(swaaowtisx) = epsejyxunr eofvubqlfg (qntcgfxcjf )
Positive
29 May 2020
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Core Patent

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Clinical Trial

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Approval

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Regulation

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