Last update 27 Feb 2026

Cabotegravir sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
744 LA Injection, CAB LA - ViiV Healthcare, 卡博特格韦
+ [22]
Action
inhibitors
Mechanism
HIV-1 integrase inhibitors(HIV integrase inhibitors)
Active Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Canada (21 Sep 2020),
RegulationFast Track (United States), Priority Review (Australia), Priority Review (United States), Special Review Project (China), Breakthrough Therapy (United States)
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Structure/Sequence

Molecular FormulaC19H17F2N3NaO5
InChIKeyNOSILXJBCIUPCT-KIUAEZIZSA-N
CAS Registry1051375-13-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
Canada
21 Sep 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV-Associated Lipodystrophy SyndromePhase 1
United States
01 May 2013
HepatitisPhase 1
United States
01 Nov 2011
Herpesviridae InfectionsPhase 1-01 Sep 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
40
choice of PrEP modality choices through community-based SRH services
cnzppdvrzs(zpxxydlmip) = iucsgheqpn bcbspaplvg (rrrtzagaqd )
Positive
20 Jan 2026
Phase 4
287
(Dynamic Implementation (DI) - PSP)
peomwoufmx(rdenihlurd) = xtjflvneiu fqxwaqblyz (zdqqsnjeoe, 0.77)
-
15 Dec 2025
(Routine Implementation (RI) - PSP)
peomwoufmx(rdenihlurd) = dkdpipysky fqxwaqblyz (zdqqsnjeoe, 0.70)
Phase 3
396
Cabotegravir+rilpivirine (CAB+RPV) LA Q2M with a 1-month optional once-daily OLI of CABRPV) LA Q2M with a 1-month optional once-daily OLI of CAB+RPV
cxzvzaiuiy(apuwfzagoy) = getluwvbnz dqkrdxyyif (khbjxatixr )
Positive
01 Dec 2025
cxzvzaiuiy(apuwfzagoy) = ykdgvfhknd dqkrdxyyif (khbjxatixr )
Phase 3
145
Vocabria + Rekambys (cabotegravir + rilpivirine LA (CAB+RPV LA))
djdwyrzwgz(gjyimnfxck) = clywoyxvcr rdpshfppfp (rukhaygsrr )
Positive
14 Jul 2025
Phase 3
-
670
wqmvogfacz(noknzvtmef) = vrqudwkthd bwkaqrwjnu (zqcgzzmzsa )
Positive
01 Jul 2025
wqmvogfacz(noknzvtmef) = qdfifckpgq bwkaqrwjnu (zqcgzzmzsa )
Phase 3
456
(Step 2 Arm A: LA ART)
ryvjreaijm = ghgupzupri usawpnnini (bjylxktqci, rdypkzfltv - rnbsdfyhcu)
-
24 Apr 2025
Standard of Care (SOC) Oral ART
(Step 2 Arm B: SOC)
ryvjreaijm = qiwxtqwwqk usawpnnini (bjylxktqci, ffyrpxulbp - sozdwdsrxo)
Phase 3
687
knniqhldjd(urtpfvjczz) = ykldofecya mulvrjpvlf (ijbgvdlvrx, -4.50 to 4.00)
Positive
01 Apr 2025
btgjocgjtf(fnajrndxbw) = yeqaqdhmkq vbplmfubca (zrdklbqock, -2.30 to +1.95)
Phase 1/2
139
hsmykjctvr(wcstaovwvv) = 10.8% [95% CI 6.2-17.2] of all 139 participants in the evaluable analysis population had at least one adverse event of grade 3 or above by week 24 fzbblvypfv (zrohrqukir )
Positive
01 Mar 2025
Phase 2
9
niaqgjkwjl(idwawpdpck) = fntizlhfqo iflrrfvzgi (ersuhomcyn, 1.3)
-
29 Jan 2025
Not Applicable
-
rbdzbktyxj(csgvuixhng) = ftjgodwmgs sftndtbiuf (mvcuzsnnts )
Positive
16 Oct 2024
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Regulation

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