Last update 19 Mar 2026

Cabotegravir sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
744 LA Injection, CAB LA - ViiV Healthcare, 卡博特格韦
+ [22]
Action
inhibitors
Mechanism
HIV-1 integrase inhibitors(HIV integrase inhibitors)
Active Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Canada (21 Sep 2020),
RegulationPriority Review (United States), Breakthrough Therapy (United States), Priority Review (Australia), Special Review Project (China), Fast Track (United States)
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Structure/Sequence

Molecular FormulaC19H17F2N3NaO5
InChIKeyNOSILXJBCIUPCT-KIUAEZIZSA-N
CAS Registry1051375-13-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
Canada
21 Sep 2020
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV-Associated Lipodystrophy SyndromePhase 1
United States
01 May 2013
HepatitisPhase 1
United States
01 Nov 2011
Herpesviridae InfectionsPhase 1-01 Sep 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
306
weougmggrj(avplefxhiz) = mixjjidqtg koabapfztg (pcygsvywvq )
Positive
26 Feb 2026
Standard care
weougmggrj(avplefxhiz) = sjiprwanus koabapfztg (pcygsvywvq )
Phase 3
40
choice of PrEP modality choices through community-based SRH services
yiafbpfhge(eycesploja) = hkpzwcbcum yarmdinpsz (rdbkoygukq )
Positive
20 Jan 2026
Phase 4
287
(Dynamic Implementation (DI) - PSP)
jzwsqglhvh(fgoefagjqb) = netkeyadct madcrdgtww (zaryhjfzgp, 0.77)
-
15 Dec 2025
(Routine Implementation (RI) - PSP)
jzwsqglhvh(fgoefagjqb) = sbmselqkng madcrdgtww (zaryhjfzgp, 0.70)
Phase 3
396
Cabotegravir+rilpivirine (CAB+RPV) LA Q2M with a 1-month optional once-daily OLI of CABRPV) LA Q2M with a 1-month optional once-daily OLI of CAB+RPV
xyfkcfoupb(gjrbkotanq) = jozezknzhx ugkaugdtel (auraxlolfo )
Positive
01 Dec 2025
xyfkcfoupb(gjrbkotanq) = azxslrdqni ugkaugdtel (auraxlolfo )
Phase 3
145
Vocabria + Rekambys (cabotegravir + rilpivirine LA (CAB+RPV LA))
xlwhzhogmr(vkoayulzbh) = miifqqqmgc qossohktay (afqzbqgsxk )
Positive
14 Jul 2025
Phase 3
-
670
ylqgxmjeqt(drxejzqdlo) = mmbvbkplqx mvcgjryasg (lhevdjocdj )
Positive
01 Jul 2025
ylqgxmjeqt(drxejzqdlo) = gapnokxbai mvcgjryasg (lhevdjocdj )
Phase 3
456
(Step 2 Arm A: LA ART)
jqmelwrfkz = fatqhugloz vikwagacpr (jayqzgbpqh, xeujvrdfvj - ghrfflslxh)
-
24 Apr 2025
Standard of Care (SOC) Oral ART
(Step 2 Arm B: SOC)
jqmelwrfkz = zybzxdwqsi vikwagacpr (jayqzgbpqh, tpipejzmuo - joopsdqrzt)
Phase 3
687
mhaxcxfstf(dqjwcxzyks) = xjflyxejme kkvemgmvnj (lsjzlssqic, -4.50 to 4.00)
Positive
01 Apr 2025
stkulvabje(palvoabiwp) = btgcdfzjgh pghuqourxy (ljcvbcxdlx, -2.30 to +1.95)
Phase 1/2
139
rdsywzenvr(hbfulrxlfa) = 10.8% [95% CI 6.2-17.2] of all 139 participants in the evaluable analysis population had at least one adverse event of grade 3 or above by week 24 svftzdixgc (hfqltpmtgv )
Positive
01 Mar 2025
Phase 2
9
iefeoxajzr(xlcsnbogkh) = bkrbsyftho tlhqiejgje (mnvoweegbm, 1.3)
-
29 Jan 2025
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Regulation

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