Last update 08 Jan 2026

Motugivatrep

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
SJP 0132, SJP-0132, AVAREPT
+ [1]
Target
TRPV1
Action
antagonists
Mechanism
TRPV1 antagonists(Transient receptor potential cation channel subfamily V member 1 antagonists)
Therapeutic Areas
Eye Diseases
Active Indication
XerophthalmiaDry Eye Syndromes
Inactive Indication-
Originator Organization
Senju Pharmaceutical Co., Ltd.
Active Organization
Senju Pharmaceutical Co., Ltd.Senju Pharmaceutical Beijing Co. Ltd.Senju Pharmaceutical Beijing Co. Ltd.
Inactive Organization-
License Organization
Mochida Pharmaceutical Co., Ltd.Mochida Pharmaceutical Co., Ltd.Senju Pharmaceutical Co., Ltd.
Drug Highest PhaseApproved
First Approval Date
Japan (22 Dec 2025),
Xerophthalmia
RegulationPaediatric investigation plan (European Union)
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Related

2
Clinical Trials associated with Motugivatrep
NCT06717152
/ CompletedPhase 3
A Randomized, Double-masked, Parallel, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of SJP-0132 Eye Drops Compared With Placebo in Chinese Patients With Dry Eye Disease
NCT04139122
/ CompletedPhase 1/2
A Randomized, Double-Masked, Single-Center, Placebo-Controlled Single and Multiple Ascending Dose Study to Assess Safety, Tolerability, Pharmacokinetics, and Efficacy of SJP-0132 in Subjects With Dry Eye Disease
100 Clinical Results associated with Motugivatrep
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100 Translational Medicine associated with Motugivatrep
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100 Patents (Medical) associated with Motugivatrep
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100 Deals associated with Motugivatrep
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Xerophthalmia
Japan
Senju Pharmaceutical Co., Ltd.
22 Dec 2025
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Dry Eye SyndromesPhase 3
China
Senju Pharmaceutical Co., Ltd.
30 Dec 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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