Delving into the Latest Updates on Phenoxybenzamine Hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Fenossibenzamina, POB, Phenoxybenzamine

+ [2]

Target

α-adrenergic receptor

Action

antagonists

Mechanism

α-adrenergic receptor antagonists(Alpha adrenergic receptor antagonists)

Therapeutic Areas

NeoplasmsCardiovascular DiseasesUrogenital Diseases+ [1]

Active Indication

Peripheral VasospasmUrinary RetentionHypertension+ [1]

Inactive Indication-

Originator Organization

Concordia NV

Active Organization

Advanz Pharma Corp. Ltd.

Suzhou Homesun Pharmaceutical Co. Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

United States (26 Jan 1953),

HypertensionPheochromocytoma

Regulation-

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Structure/Sequence

Molecular FormulaC18H23Cl2NO

InChIKeyVBCPVIWPDJVHAN-UHFFFAOYSA-N

CAS Registry63-92-3

View All Structures (2)

Pheochromocytoma and paraganglioma (PPGL) are rare neuroendocrine tumors originating from catecholamine producing chromaffin cells in the adrenal medulla and extra-adrenal paraganglia. The overall age-standardized incidence rate is 0.18 per 100,000 person-years in Korea.
The definitive treatment of PPGL is surgical excision of tumor. However, surgery is associated with a high risk of perioperative hemodynamic instability (HI). To avoid perioperative HI in patients diagnosed with PPGL, preoperative management including routine use of alpha blockade and volume expansion has been advocated by several guidelines.
While unstable hypertension and tachycardia should be controlled in patients with PPGL, there is controversial that all patients diagnosed with PPGL should undergo preoperative pharmacological treatment, especially alpha blockade. The most important risk of preoperative alpha blockade use is perioperative hypotension.
A recent study reported that patients diagnosed with PPGL postoperatively may have no further higher risk of intraoperative hypertension than those diagnosed preoperatively despite insufficient preoperatively management of PPGL.
Therefore, it is a very important to study the relationship between HI and preoperative alpha blockade in normotensive patients diagnosed with PPGL. The aim this study is to analyze the effect and safety of omitting preoperative alpha-adrenergic blockade for normotensive pheochromocytoma through a prospective randomized controlled trial. The patients is divided into two groups. The patients in control group take a phenoxybenzamine at least 2 to 5 weeks before surgery. The patients in case group do not take a phenoxybenzamine.
Primary outcome is to evaluate the percentage of time during surgery with systolic blood pressure more than 160mmHg or average blood pressure less than 60mmHg. And secondary outcomes are to evaluate hemodynamic instability in preoperative ward and postoperative ward.

Start Date18 Jan 2023

Sponsor / Collaborator

Seoul National University Hospital

NCT01379898

/ CompletedPhase 4

Pheochromocytoma Randomised Study Comparing Adrenoreceptor Inhibiting Agents for Preoperative Treatment

* Rationale: The optimal preoperative medical management for patients with a pheochromocytoma is currently unknown. In particular, there is no agreement with respect to whether phenoxybenzamine or doxazosin is the optimal alfa-adrenoreceptor antagonist to be administered before surgical resection of a pheochromocytoma. We hypothesized that the competitive alfa1-antagonist doxazosin is superior to the non-competitive alfa1- and alfa2-antagonist phenoxybenzamine.
* Objective: comparing effects of preoperative treatment with either phenoxybenzamine or doxazosin on intraoperative hemodynamic control in patients undergoing surgical resection of a pheochromocytoma.
* Study design: Randomised controlled open-label trial.
* Study population: 18 - 55 yr old. Adult patients with a recently diagnosed benign pheochromocytoma.
* Intervention: Patients are randomised to receive oral treatment with either phenoxybenzamine or doxazosin preoperatively.
* Main study parameters/endpoints: The main study parameter is defined as the percentage of intraoperative time that blood pressure is outside the predefined target range after pretreatment with either phenoxybenzamine or doxazosin.
In this multicenter trial, we compare the effects of two commonly used drugs in patients being medically prepared for resection of a benign pheochromocytoma. Participants are not subjected to an experimental treatment of any kind, as we merely aim to describe in detail the perioperative course in general and, in particular, the intraoperative hemodynamic control in patients treated preoperatively with either phenoxybenzamine or doxazosin. A routine diagnostic work-up for pheochromocytoma will be performed in all participants. One extra blood sample (volume: 48,5 mL) is drawn before start of the study medication, and participants need to record their symptoms in a diary. In addition, patients who are pretreated in the outpatient clinic monitor their blood pressure and pulse rate at home with an automated device. Treatment with an alfa-adrenoreceptor antagonist is initiated at least 2 - 3 weeks prior to surgery. Patients who are admitted to the hospital for pretreatment with an alfa-adrenoreceptor antagonist have their blood pressure and pulse rate measured by the nursing staff. The final site visit is planned at 30 days after surgery, in line with current practice.

Start Date01 Dec 2011

Sponsor / Collaborator

University Medical Center Groningen

[+14]

CTRI/2011/09/002019

/ RecruitingPhase 4IIT

Comparative study of pre-operative blockade using Phenoxybenzamine vs. Prazosin efficacy ( intra- and post-operative hemodynamic changes) and safety profile in Pheochromocytoma

Start Date27 Sep 2011

Sponsor / Collaborator

Sanjay Gandhi Post Graduate Institute of Medical Sciences

100 Clinical Results associated with Phenoxybenzamine Hydrochloride

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100 Translational Medicine associated with Phenoxybenzamine Hydrochloride

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100 Patents (Medical) associated with Phenoxybenzamine Hydrochloride

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6,466

Literatures (Medical) associated with Phenoxybenzamine Hydrochloride

01 Feb 2025·Food Chemistry

Study on the foam properties of peanut oil body (POB)-based oil-in-water-in-oil (O/W/O) foamed emulsion gel: The key role played by the interface between the water phase and the outer oil phase

Article

Author: Meng, Zong ; Shi, Zhangyu ; Li, Kangyu

A novel POB-based O/W/O foamed emulsion gel was constructed. The mechanism by which POB strengthens the foamed emulsion gel was preliminarily explored by studying the microstructure and rheological properties, and the applications of POB in decoration and 3D printing were analyzed. The adsorption of POBs and their fragments might strengthen the interface between the water and internal oil phases, thereby increasing the yield stress of the system, which protected the O/W/O structure from being damaged during whipping, and formed a special foam structure where air-in-oil (A/O) structures and O/W/O structure coexist. Besides, adding POB promoted the overrun of the emulsion gel, and the maximum overrun rate was 68.6 %. Finally, POB-based O/W/O foamed emulsion gel exhibited good decoration and 3D printing performance and is expected to become a healthy and higher-quality foamed food in the future.

01 Feb 2025·Particuology

Green synthesis and eco-biological evaluation of Ag/Fe bimetallic nanoparticles using Vallaris solanacea leaf extract targeting insecticide resistance

Author: Assiri, Nouf A. ; Azeem, Arooj ; Al-Joufi, Fakhria A. ; Jalal, Rewaa S. ; Aziz, Tariq ; Rehman, Shafiq ur ; Alshareef, Sahar A. ; Mahmood, Sarmad ; Naveed, Muhammad ; Aljabri, Maha

The emergence of insecticide resistance presents a major challenge in pest control and agriculture, while the use of conventional pesticides raises environmental and health concerns.This study addresses these issues through the green synthesis of Ag/Fe bimetallic nanoparticles (BMNPs) using Vallaris solanacea plant extract and evaluates their eco-biol. activities.The synthesized Ag/Fe BMNPs, with an average size of 30 nm as determined by SEM, were characterized by UV-Vis spectroscopy, FTIR, EDX, and SEM.In vitro assays revealed significant anti-inflammatory (91%), antioxidant (95%), anti-diabetic, anti-hemolytic, and antimicrobial activities.Addnl., the nanoparticles demonstrated 100% mortality against Sitophilus oryzae (rice weevil) and exhibited 97% degradation of the pesticide Novacide, indicating potent pesticidal and environmental remediation capabilities.Computational anal., including mol. docking and mol. dynamics simulations, revealed strong interactions between Ag/Fe BMNPs and insecticide resistance (IR) proteins, with binding energies surpassing those of traditional pesticides, suggesting an ability to circumvent resistance mechanisms.These findings highlight the potential of Ag/Fe BMNPs as a sustainable, eco-friendly alternative for pest management and environmental applications in agriculture and beyond.

16 Dec 2024·Cureus

Extra-adrenal Pheochromocytoma of the Urinary Bladder in an Adolescent Female Patient

Article

Author: Davis, James W ; Neibling, James ; Edry, Gili ; Bajaj, Kunal ; Do, Pauline

Pheochromocytoma is a catecholamine-secreting tumor that arises from the medullary chromaffin cells but can rarely be extra-adrenal in origin. We present a case of a 16-year-old female patient with uncontrolled hypertension, despite being on lisinopril and metoprolol, and associated left-sided chest pain, recurrent headaches, and an unintentional weight loss of 10 pounds in one month. Laboratory work-up showed a markedly elevated plasma metanephrine level of 4463.4 pmol/L (normal range <510 pmol/L). Since it is important to find the location, rule out malignant pheochromocytoma, and consider preoperative strategy, imaging studies were performed. Abdominal ultrasound revealed a hypervascular mass in the right adnexa, while an MRI of the abdomen and pelvis identified a lobulated soft tissue mass in the right hemipelvis with diffusion restriction that appeared to be arising from the urinary bladder. Given the clinical presentation, significant elevation in catecholamines, and MRI results, extra-adrenal pheochromocytoma (EAP) was the leading differential diagnosis. Phenoxybenzamine was initiated to control her blood pressure and a partial cystectomy was performed to excise the tumor involving the right posterolateral bladder wall. Histopathological report from urinary bladder tissue biopsy confirmed the diagnosis of EAP. This case highlights a rare and intriguing presentation of EAP arising from the urinary bladder, successfully managed with partial cystectomy.

100 Deals associated with Phenoxybenzamine Hydrochloride

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External Link

KEGG	Wiki	ATC	Drug Bank
D00507	Phenoxybenzamine Hydrochloride	C04AX02	DB00925

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Peripheral Vasospasm	China	Suzhou Homesun Pharmaceutical Co. Ltd.	01 Jan 1987
Urinary Retention	China	Suzhou Homesun Pharmaceutical Co. Ltd.	01 Jan 1987
Hypertension	United States	Advanz Pharma Corp. Ltd.	26 Jan 1953
Pheochromocytoma	United States	Advanz Pharma Corp. Ltd.	26 Jan 1953

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT00620945 (CTgov)	Not Applicable	Heart Defects, Congenital	87	Phenoxybenzamine (Phenoxybenzamine Treatment)	jccvptwwhz(fjabxcchlr) = qjlcxvynrj diaclrwntg (qiivmbpqfd, cdscgpgfmp - ehteiyevai) View more	-	20 Nov 2017
NCT00620945 (CTgov)	Not Applicable	Heart Defects, Congenital	87	Phenoxybenzamine (Phenoxybenzamine)	tyifspxhod(xuaxagdbwu) = ghmlowlvoj cbwfmbshvo (rdsnvjswxe, yytrcuffoc - qfbdyshogu) View more	-	20 Nov 2017
NCT00569855 (CTgov)	Phase 2	Heart Diseases	785	phenoxybenzamine	bnozhmkkmp(opijtjoxjj) = uuoxajmusc dnehuqwqys (kzmxndgucf, igkenkwvfx - mefyecgnwl) View more	-	01 Mar 2011