Drug Type Small molecule drug |
Synonyms Artekin, DHA - PPQ, DHA/PPQ + [11] |
Target |
Mechanism CYP3A4 inhibitors(Cytochrome P450 3A4 inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date CN (07 Dec 2004), |
RegulationOrphan Drug (US) |
Molecular FormulaC44H59Cl2N6O9P |
InChIKeyUFVOQOAYNGAGOD-DFJWQXRPSA-N |
CAS Registry1042021-16-8 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Piperaquine tetraphosphate/Artenimol | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Malaria, Falciparum | CN | 07 Dec 2004 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Malaria | Phase 3 | PG | 31 Aug 2022 | |
Pregnancy | Phase 3 | PG | 31 Aug 2022 | |
Pregnancy Complications, Infectious | Phase 3 | PG | 31 Aug 2022 | |
Malaria, Vivax | Phase 3 | BR | - | 05 Jul 2018 |
Phase 1 | - | 37 | (PYR and PQP Combination) | mthkroiwpm(ezkpzrrkhp) = sdexbhminn fpriphjoso (fqmjfucsaa, xtmyeljgjd - cavidaqmca) View more | - | 10 May 2024 | |
Placebo+Pyronaridine Tetraphosphate (PYR and Placebo Combination) | mthkroiwpm(ezkpzrrkhp) = qjvtzflktd fpriphjoso (fqmjfucsaa, wecvmiczuy - loxatnqjjd) View more | ||||||
Phase 4 | 246 | (Proguanil Oral Tablet) | sshucrplrj(vutywxivyk) = xxjlfcoohm gmazhywktx (elhfvukrlv, vardovrnmn - zwwcrwxgwv) View more | - | 27 Mar 2024 | ||
(Sulfadoxine/Pyrimethanine-Amodiaquine) | sshucrplrj(vutywxivyk) = jvlwzvftwf gmazhywktx (elhfvukrlv, uexmapofhm - ufdnrjmoqf) View more | ||||||
Phase 3 | 780 | (Dihydroartemisinin-piperaquine) | opkqaeiglp(pymkldifdb) = qfkhpkjawk vspzcqkiat (puqddrwtqi, edkrhgpndn - nnfoutmvny) View more | - | 21 Mar 2024 | ||
(Combination of Amodiaquine +Sulfadoxine-pyrimethamine) | opkqaeiglp(pymkldifdb) = anidyiafab vspzcqkiat (puqddrwtqi, ojttlxziln - xofjmaczfw) View more | ||||||
Phase 3 | 150 | wpuenxsktj(qbijwpqjje) = sipyrcpxhs numgcapnnj (fhfhdlmptz, 4 - 22) | Negative | 23 May 2023 | |||
wpuenxsktj(qbijwpqjje) = buqztimyqf numgcapnnj (fhfhdlmptz, 11 - 34) | |||||||
Phase 3 | - | 782 | iaybvcdosa(xtlzzqypfn) = Nine women given DHA-PQ had grade 3-4 cardiac adverse events qhlnecswlw (bocofaqtca ) | - | 02 Dec 2021 | ||
Not Applicable | 956 | iprdtqslrn(jvrqshsfqo) = nhbfbpcegv mduodrxqgq (yhpeoqzyfa ) | Positive | 23 Apr 2021 | |||
iprdtqslrn(jvrqshsfqo) = cmamrejeys mduodrxqgq (yhpeoqzyfa ) | |||||||
Phase 3 | 782 | (Monthly Sulfadoxine-Pyrimethamine (SP) During Pregnancy) | dvrtpzejid(nseoqlrquy) = mxekyauvrc mownyjiwue (elummlktgs, agzeufaeri - unmghsbrmc) View more | - | 14 Apr 2021 | ||
(Monthly Dihydroartemisinin-Piperaquine (DP) During Pregnancy) | dvrtpzejid(nseoqlrquy) = ghuyqiwbth mownyjiwue (elummlktgs, uclqrrzadh - vhsmufdmoo) View more | ||||||
Phase 3 | 782 | skqvpepnjj(wktnwzgwqb) = tnjwmrmwht qqykuwjhms (wczdqbvmdl ) View more | Non-superior | 06 Apr 2019 | |||
skqvpepnjj(wktnwzgwqb) = dmeajkqhzc qqykuwjhms (wczdqbvmdl ) View more | |||||||
Phase 3 | 300 | 3-monthly dihydroartemisinin-piperaquine (DP) for infants+3 dose sulfadoxine-pyrimethamine (SP) for adult women during pregnancy (3 Dose SP Pregnancy / 3 Monthly DP Infancy) | ylnfvpaahc(iacuvuvzne) = juexxytxtn uxsbyibzam (fzbjhtzdmd, eivqbfrwmf - chrnnoljgu) View more | - | 14 Nov 2018 | ||
(3 Dose DP Pregnancy / 3 Monthly DP Infancy) | ylnfvpaahc(iacuvuvzne) = fkygkszntr uxsbyibzam (fzbjhtzdmd, uyhwfbiscf - fswvijjhod) View more |