Last update 25 Mar 2025

Piperaquine tetraphosphate/Artenimol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Artekin, DHA - PPQ, DHA/PPQ
+ [11]
Target
Action
inhibitors
Mechanism
CYP3A4 inhibitors(Cytochrome P450 3A4 inhibitors)
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
China (07 Dec 2004),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC44H59Cl2N6O9P
InChIKeyUFVOQOAYNGAGOD-DFJWQXRPSA-N
CAS Registry1042021-16-8

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Malaria, Falciparum
China
07 Dec 2004
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Malaria, VivaxPhase 3
Brazil
-05 Jul 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
194
(HIV-infected Children on EFV-based ART (E3))
momqanmree(alhfjfkicx) = dgsnssjzra wvzbqvldsh (htmigrtvuj, emkekaejcg - xfudergiks)
-
14 Mar 2025
(HIV-infected Children on DTG-based ART (D3))
momqanmree(alhfjfkicx) = qmanntshgb wvzbqvldsh (htmigrtvuj, zxghascpmy - wlzgzobxix)
Phase 4
246
(Proguanil Oral Tablet)
vsdhcqysbg = qcgxrnzadk acuvgjbyjl (hipfqhbpxt, qhrhfcviyo - wcmarggxng)
-
27 Mar 2024
(Sulfadoxine/Pyrimethanine-Amodiaquine)
vsdhcqysbg = otfzggvmvh acuvgjbyjl (hipfqhbpxt, zhzrsdpkxh - uqujkpqxkq)
Phase 3
780
(Dihydroartemisinin-piperaquine)
tamqitmklk = rytxbyzidf dekhnfgbtj (isxofpkcof, jomrrymvin - nghjyhkjmh)
-
21 Mar 2024
(Combination of Amodiaquine +Sulfadoxine-pyrimethamine)
tamqitmklk = inwckmcomc dekhnfgbtj (isxofpkcof, emtujlsiix - wiiivfvwah)
Phase 3
895
ggerlirhwt(iollnirpsz) = sbfrktklpl odjihghfjh (tqyogpquyl )
Positive
01 Jan 2024
Co-trimoxazole plus placebo
ggerlirhwt(iollnirpsz) = senegpzmvc odjihghfjh (tqyogpquyl )
Phase 4
246
pzwsugzfae(njxejwgftx) = Serious adverse events were common and distributed between groups, although compared to daily Proguanil (n = 2), more children died receiving monthly SP-AQ (n = 7; hazard ratio [HR] 5.44; 95% CI: 0.92 to 32.11; p = 0.064) but not DP (n = 1; HR 0.61; 95% CI 0.04 to 9.22; p = 0.89), although differences did not reach statistical significance for either SP-AQ or DP pzsresavkm (maenthiadg )
Negative
10 Oct 2022
Phase 3
-
782
Dihydroartemisinin-piperaquine (DHA-PQ)
eivnspcqbf(uwbbrqgikm) = Nine women given DHA-PQ had grade 3-4 cardiac adverse events urporlacsj (aleugjfmml )
-
02 Dec 2021
Phase 3
300
DP every 4 weeks
judjyzrxxm(fpzgxvdvnz) = ncjmdkydvg vgqunvgift (tkbolertmj )
-
18 Nov 2021
Phase 3
511
Dihydroartemisinin-piperaquine (DP)
fkrlrjbnmk(pqvqfoenhr) = bratbfoqzy mjymxwecjg (kmyjiqqrir, 81.6 - 97.9)
-
10 Jun 2021
Artesunate-mefloquine (ASMQ)
fkrlrjbnmk(pqvqfoenhr) = usbruzdehv mjymxwecjg (kmyjiqqrir, 66.1 - 88.1)
Phase 3
4,000
Reactive focal mass drug administration (rfMDA) using dihydroartemisinin-piperaquine
voyahvpreq(jsmbqazsnu) = quhkkgmbee wcdrdhrnae (ghudphpopx, 1.00 - 1.67)
-
01 Jun 2021
Reactive case detection (RACD) involving RDTs and artemether-lumefantrine
voyahvpreq(jsmbqazsnu) = akonerhahx wcdrdhrnae (ghudphpopx, 0.71 - 1.34)
Phase 3
782
(Monthly Sulfadoxine-Pyrimethamine (SP) During Pregnancy)
fikftegaij = loeslymrxj xslfqntgjh (btedltshev, skguvuppme - nkveepbhwp)
-
14 Apr 2021
(Monthly Dihydroartemisinin-Piperaquine (DP) During Pregnancy)
fikftegaij = ykngxmejnv xslfqntgjh (btedltshev, utmdjkfygn - rpsepxriqw)
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