Hydrogen Peroxide

Neither a one-meter drop nor constant motion and vibration prevent the device from completing tests with near 100% accuracy, proving its utility at Point of Need™ in virtually any environment ALAMEDA, Calif., June 18, 2024 /PRNewswire/ -- Alveo Technologies, Inc. (Alveo), a leader in molecular sensing and diagnostics with its proprietary technology platform, today announced the results of rigorous testing that demonstrate the ruggedness of its portable molecular testing platform. Whether it fell from a significant height, endured temperature and humidity extremes, or was subjected to jarring vibrations that mimic vehicle transportation of virtually any type — the device continued to complete tests and produce accurate results. Alveo's platform has been designed to provide accurate, rapid test results at the point of need. The company tested its platform to demonstrate that it can perform reliably in harsh, real-world conditions, where markets, applications and use cases previously did not exist due to this unmet market need and requirement. Specifically, the Alveo platform underwent the following tests: Environmental resilience: The device was placed in controlled chambers at 5 degrees Celsius and 40 degrees Celsius at up to 95% humidity for 24 hours. Movement and vibration: At a third-party facility, the platform was subjected to constant motion and vibration for nearly four hours (233 minutes and 34 seconds), simulating what the device would experience in the back of a moving delivery truck. Drop testing: The device was dropped from up to 1 meter in height onto a hardwood board. Cleaning: The analyzer was wiped down 100s of times with five different common disinfectants, including commercial bleach, isopropyl alcohol and hydrogen peroxide. The results demonstrate that the Alveo platform can accurately perform tests in the field, under the most extreme of conditions. In the environmental resilience, drop, and cleaning tests, the device completed tests with 100% accuracy, and in the movement and vibration test, it also performed at 100% accuracy when the LED was facing up. When the LED was facing down during the vibration and movement test, it completed tests with 94% accuracy. The company is actively working on its next generation platform, enabling 360-degree capability with 100% accuracy. "These tests thoroughly demonstrate our platform's ability to provide consistent performance at the point of need, whether testing takes place in fields, on farms and in animal pens, remote locations, disaster zones, and beyond," said Shaun Holt, CEO at Alveo. "Our rugged design and innovative molecular detection technology make it possible for healthcare providers, veterinarians, growers, and public health officials to obtain rapid, accurate results at the point of need, enabling them to take immediate action to treat and contain diseases, bacteria, fungi, and other contaminants. Alveo is leading the way by delivering a system that works in harsh environments where fast, easy testing without compromise is needed most. This study verifies that we can produce PCR-like results for a whole new set of applications, use cases, and a much broader user base than traditional molecular diagnostic methods." For more information on how the Alveo platform performed during ruggedness testing, read the full report: Built for Point of Need™ Detection: Ruggedness Testing of the Alveo Analyzer . About Alveo Alveo is the first company to make molecular detection and diagnostics universally accessible – on the farm, in the field, in the clinic, or in the manufacturing plant – helping prevent or significantly limit the destructive impact of viruses, fungi, bacteria, and other pathogens by detecting earlier at the Point of Need™. Alveo's rugged and portable, multiplex-capable diagnostic platform employs a patented method of direct electrical sensing of nucleic acid amplification to provide affordable, rapid, and accurate results. By enabling early pathogen detection, Alveo helps manage global health, food security, and supply chain resiliency by providing actionable insights at lightspeed. Know Sooner, Act Faster™ with Alveo. For more, visit: Media contact Jeff Miller [email protected] 541-207-6413 SOURCE Alveo Technologies

Organosulfur skeletons are crucial in many fields, including pharmaceuticals and electronics. Synthesizing organosulfur skeletons requires o-bromobenzenethiols. However, conventional methods face challenges due to quick oxidation and formation of highly reactive intermediates. Researchers have now developed a new method for synthesizing o-bromobenzenethiols from aryne intermediates via bromothiolation. This method can pave the way for the synthesis of new organosulfur compounds with applications in diverse fields. Organosulfur compounds, organic compounds containing sulfur, are vital in biological processes and research fields like pharmaceuticals, biomedical imaging, agriculture, and electronics. Compounds like phenothiazine, thianthrene and thienothiophene, containing organosulfur skeletons, play pivotal roles in these domains. Multiple methods have been developed that use o-bromobenzenethiols as the key component to synthesize these compounds. This is mainly owing to the high reactivities of the thiol (sulfur atom bonded to a hydrogen atom) and bromine moieties of o-bromobenzenethiols, compounds which contain a bromine atom attached to positions one or two (ortho position) in a benzene ring next to a sulfur atom. Conventional methods to produce o-bromobenzenethiols involve addition of bromine to aniline, then using diazonium intermediates for addition of sulfur. This process poses challenges including selective addition of bromine at the ortho position, difficulty working with certain chemical groups, and the tendency of o-bromobenzenethiols to oxidize easily in air releasing unpleasant odors. Recently, scientists have found a new method with great potential to synthesize various complex aromatic compounds by selectively adding molecules on aryne intermediates. However, despite this success, creating o-bromobenzenethiols by adding a bromine molecule and a thiol group to these intermediates has been tough. This is because the sulfur-containing compounds react strongly with the aryne molecules, making it hard to control the process. To tackle this challenge, Associate Professor Suguru Yoshida and Mr. Shinya Tabata, from the Department of Biological Science and Technology, Faculty of Advanced Engineering at Tokyo University of Science, have developed a new method. Prof. Yoshida explains, "We developed a method for synthesizing stable o-bromobenzenethiol equivalents by bromothiolation of aryne intermediates with an appropriate hydrogen sulfide equivalent and an electrophilic brominating reagent, resulting in controlled reactivity at the sulfur atom which prevents subsequent additions with aryne intermediates." Their findings were made available online on 30 April, 2024 and published in Volume 26, Issue 18 of the journal Organic Letters on May 10, 2024. The researchers utilized potassium xanthate instead of hydrogen sulfide, owing to its better reactivity in aryne reactions and pentafluorophenyl bromide as an electrophilic brominating reagent. This combination allowed them to efficiently produce complex o-bromobenzenethiol equivalents called aryl xanthates. Notably, this method demonstrated good tolerance for various chemical groups and prevented the formation of unwanted products. Using aryl xanthates, the researchers prepared diverse highly functionalized organosulfur compounds, such as phenothiazines and thianthrenes, utilizing simple protocols without any foul odor, thanks to the high stability of the compounds. With readily available aryne precursors and versatile transformations achievable using o-bromobenzenethiols, this method enabled the synthesis of a wide variety of organosulfur compounds with highly fused organosulfur skeletons. Furthermore, this method holds the potential to significantly reduce the number of steps in the synthesis of multi substituted organosulfurs contributing towards drug discovery in pharmaceutical sciences. "With our method, it is now possible to synthesize sulfur-containing compounds with complex structures that are difficult to achieve using conventional methods. It can enable the development of novel organosulfur compounds that could lead to the discovery of new drugs, eco-friendly agrochemicals for sustainable agriculture, advanced materials, and organic electronics," remarks Prof. Yoshida, underscoring the potential applications of their study. This study opens new possibilities for the synthesis of organosulfur compounds with diverse applications in many fields. "Further studies on expansion of scope and applications of this method for synthesis of bioactive organosulfur compounds are underway in our laboratory," concludes a hopeful Prof. Yoshida.