Last update 24 May 2025

Sotuletinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BLZ 945
Target
Action
antagonists
Mechanism
CSF-1R antagonists(Colony stimulating factor 1 receptor antagonists)
Active Indication-
Originator Organization
Active Organization-
License Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC20H22N4O3S
InChIKeyADZBMFGQQWPHMJ-RHSMWYFYSA-N
CAS Registry953769-46-5

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Amyotrophic Lateral SclerosisPhase 2
United States
30 Dec 2019
Amyotrophic Lateral SclerosisPhase 2
Finland
30 Dec 2019
Amyotrophic Lateral SclerosisPhase 2
Sweden
30 Dec 2019
Advanced Malignant Solid NeoplasmPhase 2
United States
21 Oct 2016
Advanced Malignant Solid NeoplasmPhase 2
Japan
21 Oct 2016
Advanced Malignant Solid NeoplasmPhase 2
Israel
21 Oct 2016
Advanced Malignant Solid NeoplasmPhase 2
Italy
21 Oct 2016
Advanced Malignant Solid NeoplasmPhase 2
Singapore
21 Oct 2016
Advanced Malignant Solid NeoplasmPhase 2
Spain
21 Oct 2016
Advanced Malignant Solid NeoplasmPhase 2
Switzerland
21 Oct 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
-
qrtakhpeec(xmwgeimfao) = Downregulated genes have been noted as macrophage-specific genes, suggesting that treatment with BLZ945 is downregulating macrophages in the tumor microenvironment. lcsnklispr (xdxorypiec )
Positive
05 Apr 2024
Phase 1/2
146
tjmqrjljjd(nzqkhsxyvk) = acssdkqeya jszsubepdg (uecfutpfuz )
Positive
15 Aug 2020
tjmqrjljjd(nzqkhsxyvk) = tzwtskwvaz jszsubepdg (uecfutpfuz )
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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