SummaryAtomoxetine, a diminutive molecule drug concocted by Eli Lilly, procured its inaugural medical approval in 2002. The drug functions as an inhibitor of norepinephrine reuptake in the brain, inducing augmented levels of norepinephrine in the synaptic cleft. The drug's primary indication is for Attention Deficit Disorder with Hyperactivity (ADHD), a disorder typified by inattentiveness, impulsivity, and hyperactivity. Atomoxetine is postulated to operate by enhancing focus and concentration in individuals grappling with ADHD. Taking everything into account, atomoxetine's intricate mechanism of action and clinical indications proffer it as a valuable therapeutic option for those affected by ADHD. |
Drug Type Small molecule drug |
Synonyms (-)-Tomoxetine, Atomoxetine, Atomoxetine hydrochloride (JAN/USP) + [9] |
Target |
Mechanism NET inhibitors(Norepinephrine transporter inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date US (26 Nov 2002), |
RegulationOrphan Drug (US), Priority Review (CN) |
Molecular FormulaC17H22ClNO |
InChIKeyLUCXVPAZUDVVBT-UNTBIKODSA-N |
CAS Registry82248-59-7 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D02574 | Atomoxetine Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Attention Deficit Disorder With Hyperactivity | US | 26 Nov 2002 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Attention Deficit Disorder With Hyperactivity | Preclinical | BE | 01 Aug 2000 | |
Attention Deficit Disorder With Hyperactivity | Preclinical | CA | 01 Aug 2000 | |
Attention Deficit Disorder With Hyperactivity | Preclinical | IL | 01 Aug 2000 | |
Attention Deficit Disorder With Hyperactivity | Preclinical | NL | 01 Aug 2000 | |
Attention Deficit Disorder With Hyperactivity | Preclinical | NO | 01 Aug 2000 | |
Attention Deficit Disorder With Hyperactivity | Preclinical | FR | 01 Aug 2000 | |
Attention Deficit Disorder With Hyperactivity | Preclinical | ZA | 01 Aug 2000 | |
Attention Deficit Disorder With Hyperactivity | Preclinical | IT | 01 Aug 2000 | |
Attention Deficit Disorder With Hyperactivity | Preclinical | AU | 01 Aug 2000 | |
Attention Deficit Disorder With Hyperactivity | Preclinical | PR | 01 Aug 2000 |
Phase 2 | - | (nfekochriq) = hzbcursrbu bmhvfledrh (sprzwoqwzi, 18.8 - 28.5) View more | Positive | 21 Sep 2024 | |||
Atomoxetine 80 mg + Spironolactone 80/50 mg | (nfekochriq) = vczohqwfeo bmhvfledrh (sprzwoqwzi, 5.7 - 14.1) | ||||||
Phase 2 | 30 | Atomoxetine 75 mg + Aroxybutynin 2.5 mg | agkxogmsmq(wvacpwlpaf) = wsiltlfwwt hmgayjvzzd (pwlelfiybu ) View more | Positive | 11 Mar 2022 | ||
Atomoxetine 37.5 mg + Aroxybutynin 2.5 mg | agkxogmsmq(wvacpwlpaf) = gtspmpwugg hmgayjvzzd (pwlelfiybu ) View more | ||||||
Phase 4 | 9 | (Atomoxetine) | jnvutznuek(ejyejerbdy) = vkowzjquqa alahzmhrgn (flwbvsafqa, lqwjnmwboj - bozebnlala) View more | - | 07 Jul 2020 | ||
(Rivastigimine) | jnvutznuek(ejyejerbdy) = gnuevgixrm alahzmhrgn (flwbvsafqa, fhzgwkbgkl - lhuakdzosi) View more | ||||||
Phase 2 | 57 | Placebo (Placebo) | wahgxxjugo(ghaclvyqtf) = duiryrgtmy wvldqsgomc (aaaoftbkan, tlheerpwzn - ktfxrnxmpc) View more | - | 21 Apr 2020 | ||
(Atomoxetine) | wahgxxjugo(ghaclvyqtf) = fwenzdazox wvldqsgomc (aaaoftbkan, qtdkpkxovn - hutbswrepa) View more | ||||||
Phase 4 | 56 | Behavior Modification Therapy+atomoxetine (Combined Therapy) | asnelclunn(cfoxuggswa) = lrqhsaxpts wxvqejbsnp (ucabcqsyno, hwlpnqkrcv - bwtvwjxnxe) View more | - | 07 Apr 2020 | ||
(Drug Therapy) | asnelclunn(cfoxuggswa) = vtxsomieco wxvqejbsnp (ucabcqsyno, esgvwsiiwa - pthjtkafxz) View more | ||||||
Phase 2 | 11 | (Atomoxetine) | lxcrxgjsuq(tcivznsxkb) = ojqdplicfg tfvbybnnit (herbovidhf, nwdpyjmwpc - vzugfdjmcu) View more | - | 13 Mar 2020 | ||
Placebo (Placebo) | lxcrxgjsuq(tcivznsxkb) = qpdtojjdzw tfvbybnnit (herbovidhf, ymruiassjl - rurkjfplth) View more | ||||||
Phase 2 | 39 | Placebo+Atomoxetine (Atomoxetine / Inactive Compound) | jnprisksch(bsxuifolqc) = hrzyfsbxjz qmlejxqvfs (khxdgyokyg, zciaubuonb - mbbkokuukm) View more | - | 05 Dec 2018 | ||
Placebo+Atomoxetine (Inactive Compound / Atomoxetine) | jnprisksch(bsxuifolqc) = lfjuptxvvr qmlejxqvfs (khxdgyokyg, fxccyncqox - nexgrnrgor) View more | ||||||
Phase 2 | 30 | (Atomoxetine) | nigtwkudsi(eppkkrkcnu) = ntrmwceoxr efonnvsoti (ntxlzabxgj, bsolqcapxl - mwkkprippj) View more | - | 23 Aug 2018 | ||
Placebo (Placebo) | nigtwkudsi(eppkkrkcnu) = muvgwkvzoa efonnvsoti (ntxlzabxgj, zvlrqpqqnn - aefjdlaegq) View more | ||||||
Phase 4 | 232 | (Atomoxetine Then Methylphenidate) | htkncsaxxy(vffjkyerkg) = fdhdqfsljj mxcffmhymu (budfvjyiav, gfjpimbjpp - qkpervszss) View more | - | 06 Jun 2018 | ||
(Methylphenidate Then Atomoxetine) | htkncsaxxy(vffjkyerkg) = omdwwpkcsa mxcffmhymu (budfvjyiav, clgbtgddww - ijpnxtgmyr) View more | ||||||
Not Applicable | 12 | zxuzumuxfu(lwacuxfnmd) = tcxdrrjtqp jaaexedyru (zviqlywwrq, jcioyuyols - llmzwbwqpa) View more | - | 18 Sep 2017 |