Last update 21 Nov 2024

Atomoxetine Hydrochloride

Overview

Basic Info

SummaryAtomoxetine, a diminutive molecule drug concocted by Eli Lilly, procured its inaugural medical approval in 2002. The drug functions as an inhibitor of norepinephrine reuptake in the brain, inducing augmented levels of norepinephrine in the synaptic cleft. The drug's primary indication is for Attention Deficit Disorder with Hyperactivity (ADHD), a disorder typified by inattentiveness, impulsivity, and hyperactivity. Atomoxetine is postulated to operate by enhancing focus and concentration in individuals grappling with ADHD. Taking everything into account, atomoxetine's intricate mechanism of action and clinical indications proffer it as a valuable therapeutic option for those affected by ADHD.
Drug Type
Small molecule drug
Synonyms
(-)-Tomoxetine, Atomoxetine, Atomoxetine hydrochloride (JAN/USP)
+ [9]
Target
Mechanism
NET inhibitors(Norepinephrine transporter inhibitors)
Therapeutic Areas
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Priority Review (CN)
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Structure

Molecular FormulaC17H22ClNO
InChIKeyLUCXVPAZUDVVBT-UNTBIKODSA-N
CAS Registry82248-59-7
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Attention Deficit Disorder With Hyperactivity
US
26 Nov 2002
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Attention Deficit Disorder With HyperactivityPreclinical
BE
01 Aug 2000
Attention Deficit Disorder With HyperactivityPreclinical
CA
01 Aug 2000
Attention Deficit Disorder With HyperactivityPreclinical
IL
01 Aug 2000
Attention Deficit Disorder With HyperactivityPreclinical
NL
01 Aug 2000
Attention Deficit Disorder With HyperactivityPreclinical
NO
01 Aug 2000
Attention Deficit Disorder With HyperactivityPreclinical
FR
01 Aug 2000
Attention Deficit Disorder With HyperactivityPreclinical
ZA
01 Aug 2000
Attention Deficit Disorder With HyperactivityPreclinical
IT
01 Aug 2000
Attention Deficit Disorder With HyperactivityPreclinical
AU
01 Aug 2000
Attention Deficit Disorder With HyperactivityPreclinical
PR
01 Aug 2000
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
(nfekochriq) = hzbcursrbu bmhvfledrh (sprzwoqwzi, 18.8 - 28.5)
Positive
21 Sep 2024
Atomoxetine 80 mg + Spironolactone 80/50 mg
(nfekochriq) = vczohqwfeo bmhvfledrh (sprzwoqwzi, 5.7 - 14.1)
Phase 2
30
Atomoxetine 75 mg + Aroxybutynin 2.5 mg
agkxogmsmq(wvacpwlpaf) = wsiltlfwwt hmgayjvzzd (pwlelfiybu )
Positive
11 Mar 2022
Atomoxetine 37.5 mg + Aroxybutynin 2.5 mg
agkxogmsmq(wvacpwlpaf) = gtspmpwugg hmgayjvzzd (pwlelfiybu )
Phase 4
9
(Atomoxetine)
jnvutznuek(ejyejerbdy) = vkowzjquqa alahzmhrgn (flwbvsafqa, lqwjnmwboj - bozebnlala)
-
07 Jul 2020
(Rivastigimine)
jnvutznuek(ejyejerbdy) = gnuevgixrm alahzmhrgn (flwbvsafqa, fhzgwkbgkl - lhuakdzosi)
Phase 2
57
Placebo
(Placebo)
wahgxxjugo(ghaclvyqtf) = duiryrgtmy wvldqsgomc (aaaoftbkan, tlheerpwzn - ktfxrnxmpc)
-
21 Apr 2020
(Atomoxetine)
wahgxxjugo(ghaclvyqtf) = fwenzdazox wvldqsgomc (aaaoftbkan, qtdkpkxovn - hutbswrepa)
Phase 4
56
Behavior Modification Therapy+atomoxetine
(Combined Therapy)
asnelclunn(cfoxuggswa) = lrqhsaxpts wxvqejbsnp (ucabcqsyno, hwlpnqkrcv - bwtvwjxnxe)
-
07 Apr 2020
(Drug Therapy)
asnelclunn(cfoxuggswa) = vtxsomieco wxvqejbsnp (ucabcqsyno, esgvwsiiwa - pthjtkafxz)
Phase 2
11
(Atomoxetine)
lxcrxgjsuq(tcivznsxkb) = ojqdplicfg tfvbybnnit (herbovidhf, nwdpyjmwpc - vzugfdjmcu)
-
13 Mar 2020
Placebo
(Placebo)
lxcrxgjsuq(tcivznsxkb) = qpdtojjdzw tfvbybnnit (herbovidhf, ymruiassjl - rurkjfplth)
Phase 2
39
Placebo+Atomoxetine
(Atomoxetine / Inactive Compound)
jnprisksch(bsxuifolqc) = hrzyfsbxjz qmlejxqvfs (khxdgyokyg, zciaubuonb - mbbkokuukm)
-
05 Dec 2018
Placebo+Atomoxetine
(Inactive Compound / Atomoxetine)
jnprisksch(bsxuifolqc) = lfjuptxvvr qmlejxqvfs (khxdgyokyg, fxccyncqox - nexgrnrgor)
Phase 2
30
(Atomoxetine)
nigtwkudsi(eppkkrkcnu) = ntrmwceoxr efonnvsoti (ntxlzabxgj, bsolqcapxl - mwkkprippj)
-
23 Aug 2018
Placebo
(Placebo)
nigtwkudsi(eppkkrkcnu) = muvgwkvzoa efonnvsoti (ntxlzabxgj, zvlrqpqqnn - aefjdlaegq)
Phase 4
232
(Atomoxetine Then Methylphenidate)
htkncsaxxy(vffjkyerkg) = fdhdqfsljj mxcffmhymu (budfvjyiav, gfjpimbjpp - qkpervszss)
-
06 Jun 2018
(Methylphenidate Then Atomoxetine)
htkncsaxxy(vffjkyerkg) = omdwwpkcsa mxcffmhymu (budfvjyiav, clgbtgddww - ijpnxtgmyr)
Not Applicable
12
zxuzumuxfu(lwacuxfnmd) = tcxdrrjtqp jaaexedyru (zviqlywwrq, jcioyuyols - llmzwbwqpa)
-
18 Sep 2017
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