Last update 01 Nov 2024

APX3330

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Target
Mechanism
APE1 inhibitors(DNA-(apurinic or apyrimidinic site) lyase inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC21H30O6
InChIKeyAALSSIXXBDPENJ-FYWRMAATSA-N
CAS Registry136164-66-4

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmNDA/BLA
US
30 Jan 2018
Liver DiseasesNDA/BLA--
Inflammatory Bowel DiseasesPhase 2
US
07 Jun 2023
Macular EdemaPhase 2
US
30 Jan 2022
Diabetic macular oedemaPhase 2
US
08 Apr 2021
Nonproliferative diabetic retinopathyPhase 2
US
08 Apr 2021
Proliferative retinopathy with diabetes mellitusPhase 2
US
08 Apr 2021
Hematologic DiseasesPhase 1--
Peripheral Nervous System DiseasesPhase 1--
Diabetic RetinopathyPreclinical--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Biospace
ManualManual
Phase 2
-
(dlwbvlvbuy) = A higher percentage of placebo-treated patients had ≥ 3-step worsening on binocular DRSS from baseline compared to APX3330-treated patients at 24 weeks. ckwvsfvanp (bqgujsmbhk )
Positive
02 Nov 2023
Not Applicable
103
(iqkwczywbm) = AEs that occurred in ≥5% of subjects were pruritis, rash, and worsening of DR or DME in the placebo group artglichcz (akiehwoyxj )
Positive
20 Jun 2023
Placebo
Phase 2
103
(urugfzgwzv) = gkodarpspo nmarjndvzx (jplksxdsja )
-
01 Jun 2023
Placebo
(urugfzgwzv) = iyqupeawak nmarjndvzx (jplksxdsja )
Phase 1
19
lqdvcjzumh(jkmgsngbsj) = tfqtkqpgvi puukzzplqn (oyjqnozpps )
-
26 May 2019
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Clinical Trial

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Approval

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Regulation

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