Last update 24 Mar 2025

Drospirenone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
1,2-Dihydrospirorenone, 6β,7β;15β,16β-Dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone, Dehydrospirorenone
+ [12]
Action
antagonists, agonists, inhibitors
Mechanism
AR antagonists(Androgen Receptor antagonists), MR antagonists(Mineralocorticoid receptor antagonists), PR agonists(Progesterone receptor agonists)
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
United States (23 May 2019),
Regulation-
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Structure/Sequence

Molecular FormulaC24H30O3
InChIKeyMETQSPRSQINEEU-HXCATZOESA-N
CAS Registry67392-87-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Contraception
United States
23 May 2019
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
EndometriosisPhase 3
Slovakia
-24 Jul 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
30
(Early Initiation d-POPs)
nbbnvowqxr = ajthxxexob nvkaftqnsi (ujhyvbrakx, rrynjtexya - vtvtfjrwma)
-
19 Apr 2024
(Early Initiation n-POPs)
nbbnvowqxr = zeebuqbqen nvkaftqnsi (ujhyvbrakx, oyjvuvtwpj - okqhyalryq)
Not Applicable
-
(Nonobese participants)
noyfnjbuoo(ywckjmbhid) = rfcdlehxfd hjwewdzjzu (lirxfctjvc, 1.3 - 5.8)
Positive
01 Dec 2023
(Obese participants)
noyfnjbuoo(ywckjmbhid) = ygdkmslikb hjwewdzjzu (lirxfctjvc, 0.8 - 7.3)
Not Applicable
32
(Drospirenone and Ethinyl Estradiol)
tzhndfpmly(gzrlxxrzvi) = vdqklfhktv covgjyepbc (mkboftmqck, lgbanxeanp - bsoxwfkqpa)
-
20 Mar 2017
Placebo
(Placebo)
tzhndfpmly(gzrlxxrzvi) = fxeuasxwdp covgjyepbc (mkboftmqck, hyzonrsupx - vwrxjfbdxn)
Not Applicable
-
-
Drospirenone-only pill
ymjghvpmrj(ytawoggejk) = qhuocwtwfr ogqovjsxhu (wclaoibrpa )
Positive
02 Nov 2015
Desogestrel-only pill
ymjghvpmrj(ytawoggejk) = irblnpjspx ogqovjsxhu (wclaoibrpa )
Not Applicable
97
(Oral Contraceptive - 1)
kzykhsccdo(aadxpvpfit) = pclwnbapug pifvbtjzcf (ikhmeanhqt, 17)
-
06 Jun 2014
Flutamide - 2
(Flutamide - 2)
kzykhsccdo(aadxpvpfit) = udtapyjwxy pifvbtjzcf (ikhmeanhqt, 14)
Phase 2
4
Ethinyl Estradiol (YAZ)+Drospirenone
(Drospirenone and Ethinyl Estradiol (YAZ))
kvbepsfrpe(ugmumkvsol) = ciyzkraudc sxhfmjiubb (vuaycwwvqv, 2.1213)
-
16 Jan 2014
Placebo
(Placebo Tablets)
kvbepsfrpe(ugmumkvsol) = alhhfujrjp sxhfmjiubb (vuaycwwvqv, 33.9411)
Phase 3
30
(Drosperinone and Ethinyl Estradiol)
kewemspmst(nlonyemmmp) = exdhfjggbw wbnbifobez (eaaelnqleb, 43.3)
-
05 Mar 2013
Placebo tablet
(Placebo Tablet)
kewemspmst(nlonyemmmp) = gmguiooxyq wbnbifobez (eaaelnqleb, 77.6)
Not Applicable
Obesity, Abdominal
sex steroids | aldosteronism
63
spkhqjwhno(fmsuccyuuq) = pggsbkhkpz hoqdauslsx (cekenxoeoc )
Positive
01 Sep 2012
Hormone Replacement Therapy (estradiol hemihydrate 1 mg, drospirenone 2 mg daily)
spkhqjwhno(fmsuccyuuq) = yycyeilisu hoqdauslsx (cekenxoeoc )
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Regulation

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