Drug Type Small molecule drug |
Synonyms Karuna-Xanomeline-Trospium, KarXT, Trospium chloride/LY 246708 + [6] |
Action agonists, antagonists |
Mechanism M1 receptor agonists(Muscarinic acetylcholine receptor M1 agonists), M4 receptor agonists(Muscarinic acetylcholine receptor M4 agonists), mAChRs antagonists(Muscarinic acetylcholine receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date United States (26 Sep 2024), |
Regulation- |
Molecular FormulaC14H23N3OS |
InChIKeyJOLJIIDDOBNFHW-UHFFFAOYSA-N |
CAS Registry131986-45-3 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Schizophrenia | United States | 26 Sep 2024 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Alzheimer Disease 5 | Phase 3 | - | 31 Jul 2025 | |
Bipolar I disorder | Phase 3 | United States | 17 Jun 2025 | |
Bipolar I disorder | Phase 3 | Japan | 17 Jun 2025 | |
Bipolar I disorder | Phase 3 | Argentina | 17 Jun 2025 | |
Bipolar I disorder | Phase 3 | Australia | 17 Jun 2025 | |
Bipolar I disorder | Phase 3 | Bulgaria | 17 Jun 2025 | |
Bipolar I disorder | Phase 3 | Croatia | 17 Jun 2025 | |
Bipolar I disorder | Phase 3 | Hungary | 17 Jun 2025 | |
Bipolar I disorder | Phase 3 | India | 17 Jun 2025 | |
Bipolar I disorder | Phase 3 | Israel | 17 Jun 2025 |
Phase 3 | - | Cobenfy + APD (mITT) | xoafwupiaw(gudbratcrc) = hawpbmvuxo beezdgptop (yohrtekzvk, 1.01) Not Met View more | Negative | 22 Apr 2025 | ||
Placebo + APD (mITT) | xoafwupiaw(gudbratcrc) = calyrrucww beezdgptop (yohrtekzvk, 0.98) Not Met View more | ||||||
Not Applicable | 683 | umkdvdnhzi(rcebwrbdfm) = ddrxdebdeq pdimzixehr (ccweesttjf ) View more | Positive | 26 Feb 2025 | |||
Placebo | umkdvdnhzi(rcebwrbdfm) = cnfcaleuyx pdimzixehr (ccweesttjf ) View more | ||||||
Phase 3 | 256 | (KarXT) | iuktwfutwh(owtujtdral) = rqvjydljoe ogbqfisqrb (fyxtiwtzui, 1.584) View more | - | 09 Dec 2024 | ||
Placebo (Placebo) | iuktwfutwh(owtujtdral) = awnxljlukf ogbqfisqrb (fyxtiwtzui, 1.552) View more | ||||||
Phase 3 | 156 | ofcjznqlmg(qwvtzjhopa) = mjaslqwkim doemrtusqq (clqznwfcxp ) | Positive | 31 Oct 2024 | |||
Placebo | - | ||||||
Phase 3 | 566 | djzjwemkzy(alrspaedje) = varhgmwmwh udtjjqmcbh (lywwiqdyje ) View more | Positive | 31 Oct 2024 | |||
Phase 3 | 202 | omddqfnxbm(kfesyjqsib) = gmenbmmtda cvfutwwbgp (ptnrthjtkg ) Met View more | Positive | 29 Oct 2024 | |||
Placebo | omddqfnxbm(kfesyjqsib) = cvxnvobpie cvfutwwbgp (ptnrthjtkg ) Met View more | ||||||
Phase 3 | 152 | (KarXT Arm A) | puuyqgvuag = bdybwcchnk ifailkrzsg (atntwtdbjs, jsfuorkgpi - rprnovpwfz) View more | - | 28 Oct 2024 | ||
Placebo+KarXT (KarXT Arm B) | puuyqgvuag = hzpocjuyqd ifailkrzsg (atntwtdbjs, zihtlowsyt - lusdqkaxfs) View more | ||||||
Phase 3 | 236 | htypxptywh(racwrzeyak) = vivdgmkuoe boxblidvaa (mawfoudrqp, 1.7) | Positive | 26 Sep 2024 | |||
Placebo | htypxptywh(racwrzeyak) = hbmgmrogev boxblidvaa (mawfoudrqp, 1.6) | ||||||
Phase 3 | 234 | rqqyrmpvei(rhjhhizclb) = wtrqplcpuy luouosdpcq (gnfhjeaopb, 1.6) View more | Positive | 26 Sep 2024 | |||
Placebo | rqqyrmpvei(rhjhhizclb) = kbugjzclxr luouosdpcq (gnfhjeaopb, 1.6) View more | ||||||
Phase 3 | 4 | fybmvdaujc = rarlrkmiex rafkfukltn (onlevkpudw, luvuuihctj - urfamkrpsy) View more | - | 12 Jun 2024 |