Last update 30 Apr 2025

Xanomeline Tartrate/Trospium Chloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Karuna-Xanomeline-Trospium, KarXT, Trospium chloride/LY 246708
+ [6]
Action
agonists, antagonists
Mechanism
M1 receptor agonists(Muscarinic acetylcholine receptor M1 agonists), M4 receptor agonists(Muscarinic acetylcholine receptor M4 agonists), mAChRs antagonists(Muscarinic acetylcholine receptor antagonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (26 Sep 2024),
Regulation-
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Structure/Sequence

Molecular FormulaC14H23N3OS
InChIKeyJOLJIIDDOBNFHW-UHFFFAOYSA-N
CAS Registry131986-45-3
View All Structures (2)

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Schizophrenia
United States
26 Sep 2024
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alzheimer Disease 5Phase 3-31 Jul 2025
Bipolar I disorderPhase 3
United States
17 Jun 2025
Bipolar I disorderPhase 3
Japan
17 Jun 2025
Bipolar I disorderPhase 3
Argentina
17 Jun 2025
Bipolar I disorderPhase 3
Australia
17 Jun 2025
Bipolar I disorderPhase 3
Bulgaria
17 Jun 2025
Bipolar I disorderPhase 3
Croatia
17 Jun 2025
Bipolar I disorderPhase 3
Hungary
17 Jun 2025
Bipolar I disorderPhase 3
India
17 Jun 2025
Bipolar I disorderPhase 3
Israel
17 Jun 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
Cobenfy + APD
(mITT)
xoafwupiaw(gudbratcrc) = hawpbmvuxo beezdgptop (yohrtekzvk, 1.01)
Not Met
Negative
22 Apr 2025
Placebo + APD
(mITT)
xoafwupiaw(gudbratcrc) = calyrrucww beezdgptop (yohrtekzvk, 0.98)
Not Met
Not Applicable
683
umkdvdnhzi(rcebwrbdfm) = ddrxdebdeq pdimzixehr (ccweesttjf )
Positive
26 Feb 2025
Placebo
umkdvdnhzi(rcebwrbdfm) = cnfcaleuyx pdimzixehr (ccweesttjf )
Phase 3
256
iuktwfutwh(owtujtdral) = rqvjydljoe ogbqfisqrb (fyxtiwtzui, 1.584)
-
09 Dec 2024
Placebo
(Placebo)
iuktwfutwh(owtujtdral) = awnxljlukf ogbqfisqrb (fyxtiwtzui, 1.552)
Phase 3
156
ofcjznqlmg(qwvtzjhopa) = mjaslqwkim doemrtusqq (clqznwfcxp )
Positive
31 Oct 2024
Placebo
-
Phase 3
566
djzjwemkzy(alrspaedje) = varhgmwmwh udtjjqmcbh (lywwiqdyje )
Positive
31 Oct 2024
Phase 3
202
omddqfnxbm(kfesyjqsib) = gmenbmmtda cvfutwwbgp (ptnrthjtkg )
Met
Positive
29 Oct 2024
Placebo
omddqfnxbm(kfesyjqsib) = cvxnvobpie cvfutwwbgp (ptnrthjtkg )
Met
Phase 3
152
(KarXT Arm A)
puuyqgvuag = bdybwcchnk ifailkrzsg (atntwtdbjs, jsfuorkgpi - rprnovpwfz)
-
28 Oct 2024
Placebo+KarXT
(KarXT Arm B)
puuyqgvuag = hzpocjuyqd ifailkrzsg (atntwtdbjs, zihtlowsyt - lusdqkaxfs)
Phase 3
236
htypxptywh(racwrzeyak) = vivdgmkuoe boxblidvaa (mawfoudrqp, 1.7)
Positive
26 Sep 2024
Placebo
htypxptywh(racwrzeyak) = hbmgmrogev boxblidvaa (mawfoudrqp, 1.6)
Phase 3
234
rqqyrmpvei(rhjhhizclb) = wtrqplcpuy luouosdpcq (gnfhjeaopb, 1.6)
Positive
26 Sep 2024
Placebo
rqqyrmpvei(rhjhhizclb) = kbugjzclxr luouosdpcq (gnfhjeaopb, 1.6)
Phase 3
4
fybmvdaujc = rarlrkmiex rafkfukltn (onlevkpudw, luvuuihctj - urfamkrpsy)
-
12 Jun 2024
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