The study will test a new combination of 3 drugs: Isatuximab (Isa), Iberdomide (Iber) and Dexamethasone (Dex), in patients who have intermediate or high risk smouldering myeloma. Smouldering myeloma is an early form of myeloma which may progress to active multiple myeloma, but at a slow rate. Patients with smouldering myeloma do not usually receive any treatment but will have regular check-ups and observation. Some patients have a diagnosis of smouldering myeloma which has a higher risk of progressing to active myeloma.
The study will test if the combination of drugs is effective at preventing or delaying the disease progressing into active multiple myeloma. The study will also test if the combination is tolerated and accepted by patients.

Start Date31 Mar 2025

Sponsor / Collaborator

University College London

[+2]

NCT06785415

/ RecruitingPhase 1/2IIT

Phase 1/2 Trial of Elotuzumab, Daratumumab, Iberdomide, and Dexamethasone for Relapsed Multiple Myeloma

This phase I/II trial tests the safety, side effects, and best dose of iberdomide and how well it works in combination with daratumumab, elotuzumab, and dexamethasone in treating patients with multiple myeloma that has come back after a period of improvement (relapsed). Immunotherapy with iberdomide, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. Daratumumab is in a class of medications called monoclonal antibodies. It binds to a protein called CD38, which is found on some types of immune cells and cancer cells, including myeloma cells. Daratumumab may block CD38 and help the immune system kill cancer cells. Elotuzumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Dexamethasone is in a class of medications called corticosteroids. It is used to reduce inflammation and lower the body's immune response to help lessen the side effects of chemotherapy drugs. Giving iberdomide in combination with daratumumab, elotuzumab, and dexamethasone may be safe, tolerable and/or effective in patients with relapsed multiple myeloma.

Start Date18 Mar 2025

Sponsor / Collaborator

Mayo Clinic

NCT06232044

/ Not yet recruitingPhase 1/2IIT

A Phase I/II Study of the Safety, Tolerability and Efficacy of Belantamab Mafodotin (GSK2857916) in Combination With Iberdomide (CC-220)/Dexamethasone Versus Belantamab Mafodotin (GSK2857916)/Dexamethasone in Relapsed Refractory Multiple Myeloma

This phase I/II trial tests the safety, side effects, best dose, and effectiveness of iberdomide in combination with belantamab mafodotin and dexamethasone in treating patients with multiple myeloma (MM) that has come back after a period of improvement (relapsed) or that does not respond to treatment (refractory). Multiple myeloma is a cancer that affects white blood cells called plasma cells, which are made in the bone marrow and are part of the immune system. Multiple myeloma cells have a protein on their surface called B-cell maturation antigen (BCMA) that allows the cancer cells to survive and grow. Immunotherapy with iberdomide, may induce changes in body's immune system and may interfere with the ability of cancer cells to grow and spread. Belantamab mafodotin has been designed to attach to the BCMA protein, which may cause the myeloma cell to become damaged and die. Dexamethasone is in a class of medications called corticosteroids. It is used to reduce inflammation and lower the body's immune response to help lessen the side effects of chemotherapy drugs. Iberdomide plus belantamab mafodotin may help slow or stop the growth of cancer in patients with multiple myeloma.

Start Date31 Dec 2024

Sponsor / Collaborator

Alliance for Clinical Trials in Oncology

[+1]

100 Clinical Results associated with Iberdomide

100 Translational Medicine associated with Iberdomide

100 Patents (Medical) associated with Iberdomide

Literatures (Medical) associated with Iberdomide

01 Mar 2025·JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Effect of iberdomide on cutaneous manifestations in systemic lupus erythematosus: A randomized phase 2 clinical trial

Article

Author: van Vollenhoven, Ronald ; Dörner, Thomas ; Schafer, Peter H ; Werth, Victoria P ; Schafer, Peter H. ; Korish, Shimon ; Merrill, Joan T. ; Werth, Victoria P. ; Merrill, Joan T ; Furie, Richard ; Li, Stan ; Weiswasser, Michael ; Lipsky, Peter ; Stern, Mark ; Delev, Nikolay

BACKGROUND:

Iberdomide, a cereblon modulator, promotes degradation of transcription factors Ikaros and Aiolos.

OBJECTIVE:

Evaluate iberdomide efficacy and safety in cutaneous lupus erythematosus (CLE) in a phase 2 study.

METHODS:

Patients were randomized (2:2:1:2) to iberdomide 0.45 (n = 81), 0.30 (n = 82), or 0.15 mg (n = 42) or placebo (n = 83) daily while continuing background lupus medications.

RESULTS:

The mean (SD) baseline Cutaneous Lupus Area and Severity Index Activity (CLASI-A) score was 6.9 (7.0); 28% of patients had a score ≥8; 56% had acute CLE, 29% chronic CLE, and 16% subacute CLE. Mean CLASI-A improvement in patients with baseline score ≥8 was 39.7% for iberdomide 0.45 mg versus 20.1% for placebo at week 4 (P = .032), with continued improvement through week 24 (66.7% vs 54.2%; P = .295). Proportions of patients achieving ≥50% CLASI-A reduction from baseline at week 24 were significantly greater for iberdomide 0.45 mg versus placebo for patients with subacute (91.7% vs 52.9%, P = .035) and chronic (62.1% vs 27.8%; P = .029) CLE but not for the overall population (55.6% vs 44.6%) or patients with baseline CLASI-A ≥8 (66.7% vs 50.0%).

LIMITATIONS:

Small patient subgroups of CLE subtypes.

CONCLUSIONS:

Iberdomide showed beneficial effects when added to background lupus medications in patients with subacute and chronic CLE.

01 Feb 2025·JOURNAL OF PHARMACEUTICAL SCIENCES

A population pharmacokinetic analysis to evaluate the impact of renal impairment on the pharmacokinetics of iberdomide

Article

Author: Lin, Hongxia ; Li, Yan ; Xue, Yongjun ; Cheng, Yiming ; Chen, Ping ; Thomas, Mark ; Wang, Alice

Iberdomide, a novel potent cereblon E3 ligase modulator, is under investigation for multiple myeloma. This study assessed how renal impairment (RI) affects iberdomide pharmacokinetics (PK). Twenty-six subjects with varying renal function, including those with severe renal impairment and those requiring intermittent hemodialysis (IHD), received a single oral 1 mg dose of iberdomide. Plasma, urine, and dialysate samples were analyzed to evaluate the PK of iberdomide and its major active metabolite, M12. Data were subsequently pooled with PK data from four other clinical trials involving 354 patients to develop a parent - metabolite population PK model using nonlinear mixed-effects modeling to assess the impact of various degrees of RI on drug exposure. The population PK model effectively described the PK of iberdomide and M12, showing that normal, mild, and moderate RI had no significant impact on iberdomide PK exposure, whereas severe RI reduced total clearance and increased PK exposure of iberdomide and M12. Subjects with kidney failure on IHD had comparable total clearance and PK exposure to those with normal renal function. These findings systematically examined the effects of various degrees of RI on iberdomide PK and provide a basis for informing iberdomide dosing in patients with varying degrees of renal impairment.

01 Nov 2024·Clinical Lymphoma Myeloma & Leukemia

Cereblon E3 Ligase Modulators Mezigdomide and Iberdomide in Multiple Myeloma

Review

Author: van Rhee, Frits ; Patel, Tanvi H ; Al Hadidi, Samer

Multiple Myeloma (MM) remains a challenging hematological malignancy despite significant advancements made during the past 2 decades. Outcomes have improved by incorporating immunomodulatory drugs, proteasome inhibitors, and anti-CD38 monoclonal antibodies into treatment algorithms that include high dose chemotherapy and autologous hematopoietic stem cell transplantation. However, many patients may eventually relapse despite these innovations. Newer therapies targeting B-Cell Maturation Antigen (BCMA) offer promise for patients with relapsed or refractory disease. BCMA-targeted therapies carry notable side effects, necessitating vigilant monitoring and proactive infection prevention measures. They can also induce considerable immunosuppression, attributed to lower levels of immunoglobulins and increased susceptibility to infections. There is still a need for alternative treatment options with different mechanisms of action that can be easily administered and have a better safety profile. In addition, pomalidomide only overcomes lenalidomide refractoriness in a subset of patients. This review aims to explore 2 next-generation cereblon E3 ligase modulators (CELMoDs), Mezigdomide (CC92480), and Iberdomide (CC-220). We will discuss the biological aspects of these agents, including their mechanisms of action, efficacy, and toxicity profile, and provide a comprehensive review of current literature. Special attention will be paid to ongoing and future clinical trials that provide insights into the potential of these novel therapies in the management of MM.

News (Medical) associated with Iberdomide

07 Feb 2025

·www.fiercebiotech.com

Bristol Myers backs out of Dupixent fight, axing allergy asset despite phase 3 win

Bristol Myers Squibb remains open to deals amid the cost-cutting. \n Bristol Myers Squibb has continued its ruthless cost-cutting push, dropping plans to commercialize a rival to Dupixent despite meeting its phase 3 goals and pumping the brakes on a would-be Sotyktu successor.The Big Pharma has dropped a series of internal and partnered programs since Chris Boerner, Ph.D., took over as CEO. Boerner initially targeted $1.5 billion in savings. With that cost-cutting push underway, the CEO added another $2 billion to the target this week. BMS is looking to make some of the savings by setting a higher bar for investments.Cendakimab fell short of the bar. The antibody hits IL-13, one of the interleukins targeted by Regeneron and Sanofi’s blockbuster Dupixent. Last year, BMS reported a phase 3 trial in eosinophilic esophagitis met both co-primary endpoints, positioning the drugmaker to challenge Dupixent and Takeda’s Eohilia for the market.Yet, BMS quietly removed cendakimab from the pipeline in its fourth-quarter update. Adam Lenkowsky, chief commercialization officer at BMS, explained the removal on an earnings call with analysts Thursday. “Given the data that we have seen, we\'ve made the decision not to commercialize cendakimab,” Lenkowsky said. “We\'re going to continue to prioritize investments and opportunities where we have a competitive advantage. We can deliver the highest return for the company in areas where we believe that we have an opportunity to deliver potentially transformational outcomes for patients.”Similar thinking underpinned BMS’ decision on investing in TYK2. BMS completed a phase 2 trial of its second-generation TYK2 inhibitor BMS-986322 in psoriasis in August. The drug candidate is still listed in BMS’ pipeline but an analyst questioned the lack of progress since the phase 2 trial wrapped up, leading Samit Hirawat, M.D., head of development at BMS, to explain why the program has stalled.“We have to decide within our pipeline where we are going to really focus and prioritize,” Hirawat said. “At the current time, our focus is truly squarely on Sotyktu and maximizing that opportunity from a development and commercial perspective. So, at this time, that TYK2 is not in development.”BMS is barreling ahead in other areas, pulling forward an anticipated readout from a phase 3 study of iberdomide in multiple myeloma after adding minimal residual disease (MRD) as a co-primary endpoint. Hirawat said BMS discussed the switch with the FDA and will talk to regulators once it has results to learn “how they will see that data and what else they would need.” Further use of MRD is on the cards. “Newer endpoints are needed,” Hirawat said. “We are continuing to evaluate the potential to leverage an earlier MRD endpoint readout to accelerate the development of our multiple myeloma assets across the board, but it will all depend on the timing, the population, as well as how the event accrual is occurring.”BMS remains open to deals amid the cost cutting. The drugmaker moved into radiopharmaceuticals as part of a deal spree, inking a deal to buy RayzeBio for $4.1 billion late in 2023, and Boerner said the team is looking for opportunities to enhance the acquisition. BMS will consider business development to achieve that goal if “it makes sense for us, both financially and scientifically,” the CEO said.

Phase 3Phase 2AcquisitionExecutive ChangeClinical Trial Failure

04 Dec 2024

·www.prnewswire.com

Stay Ahead in Hematology: Strategic Competitive Intelligence for Informed Decision-Making | DelveInsight

A case study on how a leading pharma company in hematology turned to DelveInsight for long-term competitive intelligence support. DelveInsight provided an in-depth analysis of competitive activity in key hematological malignancies, helping the company stay ahead of the competition. LAS VEGAS, Dec. 4, 2024 /PRNewswire/ -- DelveInsight, a leader in healthcare competitive intelligence and consulting, released a case study on Competitive Intelligence in the Hematology Domain. A Europe-based client approached DelveInsight to evaluate a long-term partnership for insights supporting their clinical, commercial, and launch strategies for a novel oncology product targeting acute myeloid leukemia (AML), multiple myeloma, and acute lymphoblastic leukemia (ALL). The client sought detailed intelligence on competitive activity, class-wise market trends, launch estimates in countries of interest, and regulatory landscapes to inform their development and commercialization plans. An additional request for the segregation of mutation/protein expression-specific therapies was also taken into consideration. DelveInsight provided timely, in-depth analysis of the competitive landscape, emerging therapies, and regulatory situations across multiple countries. This enabled the client to make informed decisions on clinical development, market positioning, and commercialization, helping them stay ahead of the competition in the hematology space. With hundreds of thousands of new cases diagnosed annually, hematologic cancers, such as acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), and multiple myeloma, among others present a serious global health challenge while also opening doors for breakthroughs in targeted and personalized treatments. These cancers affect the blood, bone marrow, and lymphatic system, and often require aggressive therapies due to their rapid progression and complex nature. AML and ALL are particularly aggressive, with AML being one of the most common forms of leukemia in adults and ALL affecting both children and adults. Innovations in precision medicine and immunotherapy are transforming hematology, with CAR-T therapies showing promise for leukemias and CELMODs, like Iberdomide, emerging as potential successors to REVLIMID for multiple myeloma. Bristol Myers Squibb's collaboration with Karyopharm on mezigdomide highlights the growing focus on CELMODs. Additionally, FDA-approved therapies like CARVYKTI and TECVAYLI, along with ongoing advancements in bispecific antibodies and proteasome inhibitors, are reshaping the multiple myeloma treatment landscape, despite safety, cost, and manufacturing challenges. The market is rapidly evolving, with new therapies continually entering the pipeline. Several companies, including Bristol Myers Squibb, Celgene, Arcellx, Novartis, Regeneron Pharmaceuticals, Cartesian Therapeutics, Heidelberg Pharma, BeiGene, CARsgen Therapeutics, C4 Therapeutics, AbbVie (TeneoOne), Roche (Genentech), Pfizer, Agios Pharmaceuticals, Jazz Pharmaceuticals, Astellas Pharma, Novartis Oncology, Daiichi Sankyo, AstraZeneca/Astex Pharmaceuticals, Chimerix, Takeda, Rafael Pharmaceuticals Inc., Delta-Fly Pharma, GlycoMimetics Incorporated, BerGenBio ASA, MacroGenics, Syndax Pharmaceuticals, Arog Pharmaceuticals, Forma Therapeutics, Sellas Life Sciences Group, Autolus Therapeutics, Cellectis, Wugen, Servier, Allogene, and Precision BioSciences, are currently advancing the therapeutic landscape for hematological disorders. As research and innovation progress, there is renewed hope for improving survival rates and enhancing the quality of life for those affected by these challenging diagnoses. DelveInsight's Methodology for Competitive Intelligence in the Hematology Domain helped the client by: Comparative Analyses: Evaluating competitor products to identify strengths, weaknesses, and market positioning, enabling the client to understand where their product stands relative to competitors along with identifying the patient segment with high unmet need KOL Insights: Gathering opinions from Key Opinion Leaders (KOLs) on clinical development strategies, client's product acceptability scenarios, data presentation, probable uptake of their asset,, providing valuable perspectives to refine the client's approach. Current Treatment Paradigms: Analyzing existing treatment approaches to identify market trends, gaps, and unmet needs, helping the client position their product effectively in the market. In-depth Competitive Benchmarking: Assessing competitors' commercial launch preparedness, patient awareness campaigns, and pricing strategies to inform the client's product's market entry and competitive strategy. Market Intelligence: Providing insights into competitors' marketing, sales, and patient engagement approaches, guiding the client's commercialization and go-to-market strategies. Clinical Development Trends: Evaluating clinical trial timelines and strategies, tracking phase shifts in terms of probability of their entry into the higher phase, and analyzing trial data to anticipate future market shifts and inform strategic decision-making. Pricing and Access Strategies: Analyzing competitor pricing models and access strategies, allowing the client to make informed decisions on pricing and reimbursement for their product. Request a proposal to see how DelveInsight's Competitive Intelligence services can support your long-term strategic insights. How DelveInsight's In-Depth Competitive Intelligence in Hematology Helped Clients Stay Ahead in the Market Periodic Competitive Inputs: Provided regular updates on competitor activities, keeping the client informed of market shifts. Enhanced Market Awareness: Delivered ongoing insights into competitor strategies, enabling quick adaptation to market changes. Short-Term Strategies: Developed actionable strategies for immediate response to competitor moves. Counter-Messaging Design: Assisted in crafting counter-messaging strategies to address competitor claims and strengthen brand positioning. Positioning Refinement: Helped refine product positioning to gain a competitive advantage. Promotional Strategy Support: Offered recommendations on promotional tactics to boost market presence and attract key audiences. Why Choose DelveInsight? DelveInsight offers tailored, comprehensive competitive intelligence to keep your hematology product developmental and commercial strategy a step ahead. With expertise in AML, Multiple Myeloma, ALL, and other hematology domains, we support your clinical, commercial, and launch strategies with insights that matter. What Sets Us Apart: Timely Intelligence: Consistent, real-time updates on competitor activities, clinical shifts, and regulatory changes, ensuring you're never caught off-guard. Expert Analysis: From comparative assessments to pricing benchmarks, we provide actionable data that sharpens your positioning. Strategic Edge: We don't just offer data—we deliver strategic recommendations for counter-messaging, promotional tactics, and market adaptation. Choosing DelveInsight means partnering with a team dedicated to turning competitive intelligence into growth and success for your business. Transform your business with our case study. Schedule a call with our DelveInsight Business Development expert today! Conference Coverage Services : DelveInsight's Conference Coverage Services offer a thorough analysis of outcomes from major events like ASH, EHA, AACR, ESMO, ASCO, and others. This detailed examination provides businesses with essential insights for competitive intelligence and market trend forecasting, supporting the formulation of future strategies. Competitive Intelligence Services: DelveInsight's competitive intelligence services provide real-time, accurate insights across the pharmaceutical, life sciences, and medical diagnostics sectors, helping clients stay ahead in a dynamic market. With over 100 years of combined experience, our experts deliver actionable strategic insights, backed by robust research methodologies, to support critical business decisions and create a competitive advantage for our clients. Hematology Pipeline Assessment: Our hematology pipeline evaluation offers a comprehensive overview of cancer treatment options, clinical trials, and key areas within the hematological disorders field, all summarized in an accessible report format. The hematology-focused reports, available in our Report Store, provide in-depth insights into treatment strategies, mechanisms of action (MoAs), drug components, and launch plans for therapies in the late stages of development. This assessment enhances understanding of their launch timelines and strategic initiatives. R&D Analysis: Our skilled research and development analyst specializes in the complexities of hematology, offering essential insights and advice to clients aiming to advance in hematological research and development. They utilize a methodical assessment approach, aligned with industry norms, to track the progress of each hematology drug in both pre-clinical and clinical stages. DelveInsight's comprehensive hematological reports are crafted to reduce uncertainties and highlight overlooked areas, providing organizations with timely and strategic intelligence. About DelveInsight DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve . Contact Us Shruti Thakur [email protected] +14699457679 Logo: SOURCE DelveInsight Business Research, LLP WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

ImmunotherapyASH

29 Oct 2024

·www.globenewswire.com

Starton Therapeutics Announces Notice of Allowance for U.S. Patent Application 17/518,930 “Continuous Delivery of Lenalidomide and Other Immunomodulatory Agents” Including Transdermal Administration

Significantly expands scope of patent coverage for Company’s proprietary drug delivery systems to now include transdermal deliveryPatent expected to issue from the pending application will have term extending to 2040, excluding any patent term adjustments or patent term extensions that may provide additional protectionSTAR-LLD is being developed for use in hematological malignancies which includes multiple myeloma (MM), chronic lymphocytic leukemia (CLL), and others. PARAMUS, N.J., Oct. 29, 2024 (GLOBE NEWSWIRE) -- Starton Therapeutics Inc. (“Starton” or the “Company”), a clinical-stage biotechnology company transforming standard-of-care therapies with proprietary dermal technologies, announced today that the U.S. Patent and Trademark Office (USPTO) has issued a Notice of Allowance for U.S. Patent Application No. 17/518,930, covering STAR-LLD, the Company’s continuous delivery lenalidomide program. The notice of allowance for U.S. Patent Application No. 17/518,390, entitled, “Continuous Delivery of Lenalidomide and Other Immunomodulatory Agents,” includes claims directed to the delivery of immunomodulatory imide compounds including lenalidomide, pomalidomide, iberdomide, or a combination thereof with a transdermal delivery system. The Company’s previously granted U.S. Patent No. 11,197,852, covered drug delivery systems utilizing parenteral delivery by subcutaneous infusion. The allowed claims in this patent application significantly expands the scope of patent coverage by now including drug delivery systems that utilize transdermal delivery systems for continuous low-dose delivery profile of lenalidomide. “We are delighted to receive this notice from the USPTO, further expanding the protection of our continuous delivery lenalidomide program,” stated Pedro Lichtinger, the Company’s Chairman and CEO. “The transdermal delivery system that is the subject of the allowed patent application demonstrates our unique approach to lowering drug exposure and AUC (area-under-the-curve) to potentially improve efficacy and safety and demonstrate superiority.” The Company’s transdermal delivery system administers the immunomodulatory imide compound at a dose rate that is 10-75% of the daily dose of the oral and achieves blood levels of the compound that is equivalent to the blood level at a time point from 8 hours to 18 hours obtained from once daily oral dose. The transdermal application in the allowed claims of lenalidomide and other IMiDs is expected to obtain suitable blood levels which would equate to the continuous and low-dose levels of the subcutaneous administration in an easy to apply drug product. Once granted, the patent expected to issue from the pending application will have a term extending to 2040, excluding any patent term adjustments or patent term extensions that may provide additional protection. Starton retains full global ownership of the patent applications and granted patents with the technology and methodology being developed internally. About STAR-LLD STAR-LLD is a continuous delivery lenalidomide (LLD) in development to expand and replace the standard-of-care for the most common blood cancers, multiple myeloma (MM), and chronic lymphocytic leukemia (CLL). A preclinical proof-of-concept study for subcutaneous STAR-LLD demonstrated that MM tumors caused by human myeloma cells grew 25-fold if untreated, five-fold when treated with daily lenalidomide, and shrank by 80% with STAR-LLD over a single 28-day cycle. The study also showed a 100% overall response rate (ORR) using continuous delivery LLD and 20% of animals in this cohort were tumor-free after 100 days, compared to a 0% ORR in animals treated with a 70% higher dose of lenalidomide given in single daily doses. In addition, a Phase 1 bioavailability study in healthy men comparing subcutaneous STAR-LLD to Revlimid® demonstrated the drug is well tolerated and is >91% bioavailable by the subcutaneous route. It was also observed that the Cmax is <90% lower than oral Revlimid®. About Starton Therapeutics Starton Therapeutics is a clinical-stage biotechnology platform company focused on transforming standard-of-care therapies with proprietary continuous delivery technology, so people with cancer can receive continuous treatment to live better, longer. Starton’s proprietary transdermal technology is intended to increase the efficacy of approved drugs, make them more tolerable, and expand their potential use. To learn more, visit www.startontx.com. Forward Looking Statements All statements other than statements of historical facts included in this press release, including, without limitation, statements regarding our plans and objectives for future operations and expectations about current and future clinical trials, constitute “forward-looking statements.” Forward-looking statements are subject to numerous conditions and known and unknown risks and uncertainties that could cause our actual results or events to differ materially from those included within the forward-looking statements. Readers are cautioned not to place undue reliance on these forward-looking statements and, except as required by law, the Company undertakes no obligation to disclose any revision to these forward-looking statements whether as a result of new information, future events, or otherwise. Contact Investors@startontx.com

Clinical ResultImmunotherapyPhase 1

100 Deals associated with Iberdomide

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KEGG	Wiki	ATC	Drug Bank
D11134	-	-	DB12101

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Multiple Myeloma	Phase 3	United States	Alcami Corp.	23 Jun 2022
Multiple Myeloma	Phase 3	Japan	Alcami Corp.	23 Jun 2022
Multiple Myeloma	Phase 3	Australia	Alcami Corp.	23 Jun 2022
Multiple Myeloma	Phase 3	Austria	Alcami Corp.	23 Jun 2022
Multiple Myeloma	Phase 3	Belgium	Alcami Corp.	23 Jun 2022
Multiple Myeloma	Phase 3	Brazil	Alcami Corp.	23 Jun 2022
Multiple Myeloma	Phase 3	Canada	Alcami Corp.	23 Jun 2022
Multiple Myeloma	Phase 3	Czechia	Alcami Corp.	23 Jun 2022
Multiple Myeloma	Phase 3	Denmark	Alcami Corp.	23 Jun 2022
Multiple Myeloma	Phase 3	Finland	Alcami Corp.	23 Jun 2022

Clinical Result

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT04392037 (ICON, ASH2024) Manual	Phase 2	Multiple Myeloma	61	IberdomideCyclophosphamideDexamethasone	uupcbhivya(omvyfjqmcx) = gmxslilqwz tbzudkgilm (bjcqnbvukt, 14 - 22) View more	Positive	08 Dec 2024
ASH2024	Not Applicable	Smoldering Multiple Myeloma	-	Iberdomide	phfrjyctui(uxrjqmvshd) = Six patients were diagnosed with COVID-19 while on study tfubuvyecs (vssshdeudc ) View more	-	07 Dec 2024
				Iberdomide + Dexamethasone
ASH2024	Not Applicable	Multiple Myeloma	-	Iberdomide	wvwemknvxh(mifnlhonjn) = scgcxaswaj epwcyekycs (uxpptpatad )	-	07 Dec 2024
SOHO2024	Not Applicable	-	-	Iberdomide	zecwystbwv(saiifsgsyl) = Grade 3–4 treatment-emergent adverse events (TEAEs) occurred in 70.6% patients; most common were neutropenia (17.6%) and infections (17.6%). Occurrence of other Grade 3–4 TEAEs was low. hpnakgngoi (ucmxwnycwm )	-	04 Sep 2024
NCT02773030 (CC-220-MM-001, Pubmed)	Phase 1/2	Multiple Myeloma CRBN genetic dysregulation	-	Iberdomide	jhbqqvaveq(euiapccfzq) = ipsrodongm wpftxbsiqa (kgwhfobrog ) View more	Positive	18 Jun 2024
				Placebo	jhbqqvaveq(euiapccfzq) = zjsehxbjzg wpftxbsiqa (kgwhfobrog ) View more
NCT04998786 (I2D, ASCO2024)	Phase 2	Relapse multiple myeloma	70	Iberdomide	bdypogntub(ddpscyyepx) = feiahfdxbj bbmsuofrfx (dxtsxbwjmx ) View more	Positive	24 May 2024
				Ixazomib	mqpkystvgx(rpodaocydl) = ppzrlrvjyd rvznwuxmsd (oylwkyfnob )
NCT04392037 (ICON, EHA 12024 \| EHA 22024) Manual	Phase 2	Multiple Myeloma	61	IBERDOMIDE+CYCLOPHOSPHAMIDE+DEXAMETHASONE	vyivfdcvek(pjrbeqsjae) = tyjiqdnqob aimqhsbwlm (ipxmmhdekz, 11.9 - 22.3) View more	Positive	14 May 2024
				IBERDOMIDE+CYCLOPHOSPHAMIDE+DEXAMETHASONE (patients who had received 2 prior line)	vyivfdcvek(pjrbeqsjae) = ktwaivwzhc aimqhsbwlm (ipxmmhdekz )
NCT04998786 (I2D, EHA2024) Manual	Phase 2	Multiple Myeloma Second line	54	Iberdomideixazomibdexamethasone	pxphmpztig(drqavxyboz) = gkyblfpnxt vhzzeoefva (jfnnmwvymy ) View more	Positive	14 May 2024
NCT02773030 (CC-220-MM-001, EHA2024) Manual	Phase 1/2	Multiple Myeloma CRBN \| Aiolos \| Ikaros	75	Iberdomide 1.0 mgDARATUMUMABdexamethasone	mtzjwmgfgg(lizefqlwrd) = cfhqfjjkwt fkxumhkmcn (ihkudxsxfm )	Positive	14 May 2024
				Iberdomide 1.3 mgDARATUMUMABdexamethasone	mtzjwmgfgg(lizefqlwrd) = iizxvggchv fkxumhkmcn (ihkudxsxfm )
NCT04564703 (EMN26, EHA 12024 \| EHA 22024) Manual	Phase 2	Multiple Myeloma Maintenance	120	Iberdomide 0.75 mg	clhdgggbam(dscdumknxz) = ansdlnkbzm ffocheacjt (ideapsmcvq, 50 - 79) View more	Positive	14 May 2024
				Iberdomide 1.0 mg	clhdgggbam(dscdumknxz) = jssojddkws ffocheacjt (ideapsmcvq, 19 - 48) View more

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