Last update 21 Nov 2024

JBI-802

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
LSD1/HDAC6 dual inhibitors, Lysine specific demethylase 1 and histone deacetylase 6 inhibitors, N-hydroxy-4-((4-((((1R,2S)-2-phenylcyclopropyl) amino)methyl)-1H-pyrazol-1-yl)methyl)benzamide hydrogen bromide.
+ [2]
Mechanism
HDAC6 inhibitors(Histone deacetylase 6 inhibitors), KDM1A inhibitors(Lysine-specific histone demethylase 1 inhibitors)
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC21H22N4O2
InChIKeyVLTIYMVMEIUCSB-VQTJNVASSA-N
CAS Registry2982787-49-3

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Locally Advanced Malignant Solid NeoplasmPhase 2
US
08 Apr 2022
Metastatic Solid TumorPhase 2
US
08 Apr 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
11
(doaexoxctk) = Platelet decrease is the only adverse event above grade 1 observed in these patients, no AEs (Adverse Events) of anemia has been observed, which is potentially due to the positive benefit of inhibition of HDAC6 in erythrocytes. Also, there are no reports of Dysgeusia, an adverse event that has been observed with LSD1-only inhibitors. rlqvjgcwsk (lghkezchyf )
Positive
08 Jan 2024
(NSCLC)
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Regulation

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