Colecalciferol

TUESDAY, Dec. 10, 2024 -- Vitamin D 3 supplementation does not significantly reduce the risk for developing diabetes among older adults who are not at high risk for diabetes, according to a study published online Dec. 2 in Diabetologia . Jyrki K. Virtanen, Ph.D., from the University of Eastern Finland in Kuopio, and colleagues conducted a five-year randomized trial involving 2,271 male and female participants aged 60 years and older and 65 years and older, respectively, who were free of cardiovascular disease or cancer and did not use diabetes medications. Participants were randomly assigned to receive placebo, 1,600 IU/day of vitamin D 3 , or 3,200 IU/day vitamin D 3 (760, 744, and 767 participants, respectively). The researchers identified 38 (5.0 percent), 31 (4.2 percent), and 36 (4.7 percent) type 2 diabetes events in the placebo, 1,600-IU/day, and 3,200-IU/day vitamin D 3 groups, respectively. The hazard ratio was not significant when the two vitamin D 3 arms were combined and compared with the placebo arm. The hazard ratios in the combined vitamin D 3 arms versus placebo were not significant in analyses stratified by body mass index (BMI). In a subcohort of 504 participants with a mean serum 25-hydroxyvitamin D 3 concentration of 74.5 nmol/L at baseline, there were no differences seen in changes in plasma glucose or insulin concentrations, BMI, or waist circumference during 24 months of follow-up. "Our findings do not suggest benefits of long-term moderate- or high-dose vitamin D 3 supplementation for incidence of type 2 diabetes or glucose metabolism or body size among generally healthy older vitamin D-sufficient men and women who were not at high risk for type 2 diabetes," the authors write. Several authors disclosed ties to the pharmaceutical and nutrition industries. Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

WEDNESDAY, Dec. 4, 2024 -- Taking even high doses of supplementary vitamin D won't lower an older person's odds for type 2 diabetes , new research confirms. Vitamin D supplements may have other benefits, but in otherwise healthy folks with sufficient levels of the nutrient, "our findings do not suggest benefits of long-term moderate- or high-dose vitamin D 3 supplementation" in warding off type 2 diabetes, the team of Finnish researchers concluded. They published their findings Dec. 2 in the journal Diabetologia . The new research followed on data from other studies that had suggested that people with especially low levels of vitamin D might face a higher risk for diabetes. That was true for people who were already prediabetic, especially. So could a relatively high dose of vitamin D supplements help lower type 2 diabetes rates among people without prediabetes -- those at no special risk for the blood sugar disease? To find out, researchers led by Jirki Vyrtanen , from the University of Eastern Finland, randomly assigned nearly 2,300 people aged 60 or older to receive either placebo pills or 40 or 80 micrograms of vitamin D3 supplements per day, for five years. At the end of the five years, "105 participants developed type 2 diabetes: 38 in the placebo group, 31 in the group receiving 40 micrograms of vitamin D3 per day, and 36 in the group receiving 80 micrograms of vitamin D3 per day," according to a university news release. In other words, there were no significant differences in the rate at which people developed type 2 diabetes, regardless of how much supplemental vitamin D they took. Vytanen's team also saw no benefit from high-dose supplements on a person's blood sugar or insulin levels, or measures of overweight/obesity. The bottom line, according to the researchers: For any healthy, non-prediabetic person with healthy vitamin D levels, upping intake of the vitamin won't alter your odds for diabetes or its common risk factors. Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.