Resmetirom

The plan for this year is to conduct a drug-to-drug interaction study of ervogastat with Rezdiffra as well as consult with the FDA on the design of a phase 2 combination trial.\n Madrigal has paid Pfizer $50 million for the rights to a DGAT2i inhibitor with the intention of combining the drug with its approved liver disease med Rezdiffra.Madrigal’s thyroid hormone receptor-beta (THR-beta) agonist Rezdiffra became the first-ever drug to be approved by the FDA for metabolic dysfunction-associated steatohepatitis (MASH) back in 2024. The therapy has proven a hit for the company, which is expecting full-year sales for 2025 to top $1 billion.The idea behind acquiring Pfizer’s DGAT2i inhibitor, called ervogastat, is to expand Rezdiffra’s potential. The plan for this year is to conduct a drug-to-drug interaction study of ervogastat and Rezdiffra as well as consult with the FDA on the design of a phase 2 trial for a combination treatment of both drugs.DGAT-2 inhibitors block the final step in triglyceride assembly and storage, resulting in lower hepatic triglycerides, reduced lipotoxic fat and decreased inflammation, Madrigal explained in the Jan. 9 release.“This differentiated mechanism offers the potential for additive clinical benefit when combined with Rezdiffra, a THR-β agonist that increases the cell’s ability to process fat via mitochondrial biogenesis,” the biopharma added.Madrigal also pointed to phase 2 data showing that 72% of patients treated with 150 mg ervogastat achieved at least a 30% reduction in liver fat, while 61% achieved at least a 50% reduction.Ervogastat was an asset in need of a good home. In November, Pfizer announced it was ending work on a MASH combination treatment of ervogastat and an acetyl-CoA carboxylase inhibitor called clesacostat. While Pfizer continued to list ervogastat in its pipeline as a monotherapy, there didn’t appear to be any further trials planned for the drug. In return for the license to ervogastat—along with the rights to two undisclosed early-stage MASH assets—Madrigal has handed over $50 million upfront. While potential milestone payments are also attached to the deal, the companies didn’t share those details.“Our global license agreement for ervogastat aligns with our long-term leadership ambition, and we believe Madrigal is uniquely positioned to advance this promising phase 2 asset and unlock its full clinical and commercial value through a development program focused on combination therapy with Rezdiffra,” Madrigal CEO Bill Sibold said in this morning’s release.Madrigal may have been the first to score an approval for the tricky indication of MASH, but there is plenty of competition on the horizon—including from Novo Nordisk’s GLP-1 Wegovy, which gained an FDA label expansion for the disease last year.“MASH is a complex disease that will require multiple treatment approaches to address the full spectrum of patient needs,” Madrigal’s Chief Medical Officer David Soergel, M.D., said in today’s release.“With Rezdiffra as the anchor and a world-class R&D team, our broadened portfolio now spans several key pathways that will define the future of MASH treatment,” Soergel added. “Along with studies of our oral GLP-1 receptor agonist, we look forward to adding ervogastat to our growing clinical program.\"