Last update 31 May 2025

ADX-038

Overview

Basic Info

Drug Type
siRNA
Synonyms
ADX 038, ADX038
Target
Action
modulators
Mechanism
CFB modulators(Complement factor B modulators), RNA interference
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Age Related Macular DegenerationPhase 2-01 Aug 2025
Geographic AtrophyPhase 2-01 Aug 2025
Complement Factor H DeficiencyPhase 2-01 Jul 2025
Glomerulonephritis, IGAPhase 2-01 Jul 2025
Hemoglobinuria, ParoxysmalPhase 2
Australia
07 Aug 2023
Hemoglobinuria, ParoxysmalPhase 2
United Kingdom
07 Aug 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Primary Hyperoxaluria Type 1
alanine glyoxylate aminotransferase (AGT)
1
siRNA therapy
edsedaeicw(kafutughyb) = xxayqrviht srzqphoqgf (egjfzqflpb )
Positive
05 Nov 2022
Not Applicable
-
-
aPD-1siRNAchol
ytjavdtovk(bmdtaltxtl) = cvvatlwibh oynsbkngyo (praykvqcct )
-
09 Dec 2021
Not Applicable
Metabolic Syndrome
apolipoprotein CIII
-
apoCIII-siRNA
gdvsakjkdi(ziiwzaxvhw) = harjgjgvks rajxxumewv (wazxxqprxn, 6.8)
Positive
30 Sep 2021
control-siRNA
njmwmhdhqf(iluujghcoa) = dsbkvickle gyurfhyxbu (twybzsfhws, 34.9)
Not Applicable
-
-
ipmwtfcdld(bpsqjmgpyr) = wlhrddwscq gspkwiifnc (zdcscoimmp )
-
01 May 2016
Phase 1
15
ffyxwbisvc(fjtyzrfzpe) = Most common treatment-related AEs: fatigue (47%), fever/chills (33%), allergic (33%), constipation (33%), nausea/vomiting (20%), all g1-2. 1 pt had g3 anemia and 2 pts had g2 thrombocytopenia, all shortly after CALAA-01 infusions with rapid recovery. 1 pt had possibly-related sinus bradycardia (g2) klyzgvxakv (jabgjwykix )
-
20 May 2010
Not Applicable
-
LPD nanoparticle formulation
rwredtvzgb(ejbzgutaox) = bhigxfplnk pglqvwkdxq (zxoujcciqw )
-
01 May 2008
Not Applicable
-
PEG/PPD-MEND
hszmjznakd(xabsydqxcv) = remained normal value even after i.v. administration of PEG/PPD-MEND ijeldjaqeo (dtzoxwnqrg )
-
01 May 2008
Not Applicable
-
siRNA for ß1 (007)
omitguusad(yyyocfatmy) = uddkufvyyo lkryotkcxt (xzmlzjoorv )
Positive
01 May 2006
ß2/012 siRNA
omitguusad(yyyocfatmy) = zfptrktijm lkryotkcxt (xzmlzjoorv )
Not Applicable
-
E3L-specific siRNA
fnbkpvjnkx(lobhycnrcy) = wyddymfkln qaaqvdlmfs (oaehsmzooz )
-
01 May 2005
Not Applicable
-
Stabilized siRNA
llkzxniqzk(nvfvbwyldm) = omvflphrtu ilafuqdwsm (pnpgtmxkpv )
-
01 May 2005
SNALP containing anti-HBV siRNA
xqnbohmzdb(bvmhfijnbn) = fiqsabkbul qsieggheef (qveewgjmnx )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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