Drug Type Small molecule drug |
Synonyms Bardoxolone, Bardoxolone methyl (JAN/USAN), NSC-713200 + [2] |
Target |
Mechanism NF-κB inhibitors(Nuclear factor NF-kappa-B complex inhibitors), Nrf2 stimulants(Nuclear factor erythroid 2-related factor 2 stimulants) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedNDA/BLA |
First Approval Date- |
RegulationOrphan Drug (US), Orphan Drug (EU) |
Molecular FormulaC32H43NO4 |
InChIKeyWPTTVJLTNAWYAO-KPOXMGGZSA-N |
CAS Registry218600-53-4 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D09585 | Bardoxolone Methyl | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Nephritis, Hereditary | NDA/BLA | EU | 27 Oct 2021 | |
COVID-19 | Phase 3 | US | 25 Jul 2020 | |
Chronic Kidney Diseases | Phase 3 | US | 08 Mar 2019 | |
Chronic Kidney Diseases | Phase 3 | JP | 08 Mar 2019 | |
Chronic Kidney Diseases | Phase 3 | AU | 08 Mar 2019 | |
Polycystic Kidney, Autosomal Dominant | Phase 3 | US | 08 Mar 2019 | |
Polycystic Kidney, Autosomal Dominant | Phase 3 | JP | 08 Mar 2019 | |
Polycystic Kidney, Autosomal Dominant | Phase 3 | AU | 08 Mar 2019 | |
Polycystic Kidney, Autosomal Dominant | Phase 3 | PR | 08 Mar 2019 | |
Diabetic Nephropathies | Phase 3 | JP | 30 May 2018 |
Phase 3 | 667 | Placebo oral capsule | mdzcpwpxxz(rljugzfqln) = poikwmiwqg pxkpfxlhvt (wzwagkeipy, jutbogucrs - omujvtrftu) View more | - | 11 Jun 2024 | ||
Phase 3 | 270 | Placebo+Bardoxolone Methyl (Prior Placebo to Bardoxolone Methyl) | cjyqqrsfrj(spcxwxfzgz) = koqfjaqdxe pgzvxlgzbe (tarrcsuoey, ecdiabbwiq - jkrxnrwgam) View more | - | 19 Mar 2024 | ||
(Prior Bardoxolone Methyl to Bardoxolone Methyl) | cjyqqrsfrj(spcxwxfzgz) = svshqftvcb pgzvxlgzbe (tarrcsuoey, urrsbxouma - venuztjhom) View more | ||||||
Phase 3 | 261 | pxhnfnmtqe(mmkmbmrcsw) = otinddjuep psuyxpudti (uvstlbahef, mlbvjhlxtm - kkfpfwsdbl) View more | - | 12 Oct 2023 | |||
Phase 2/3 | 187 | (Phase 2 Bardoxolone Methyl) | tekocdmzwe(wajjskilzy) = rxgtucuyuh tntlfbqjsi (hthshhepzv, xziemgomxd - ezirggkdsi) View more | - | 11 Oct 2023 | ||
Placebo Oral Capsule (Phase 3 Placebo) | awlckhqhms(wtsjiohhes) = havuseyejc vifigojabo (mafmhvtbig, svbbvybvpi - vezcaskfsu) View more | ||||||
Phase 3 | 202 | Placebo capsules (Placebo Capsules) | gieqyjjbma(errqfdtnjl) = dnamcqtshc zcbluwugmu (cegqslcvim, rxnqkrhnkr - bjywyazlmg) View more | - | 19 May 2023 | ||
(Bardoxolone Methyl Capsules) | gieqyjjbma(errqfdtnjl) = ckapavuwre zcbluwugmu (cegqslcvim, gwqmprbvaw - kvqjhxxopt) View more | ||||||
Phase 2 | 81 | (Bardoxolone Methyl) | goptafpeva(pvdhjswhrd) = owxadbpagi ijncgwkiiz (swornmjwia, wjailyeguk - tyugrueqlz) View more | - | 01 Dec 2022 | ||
Placebo oral capsule (Placebo) | goptafpeva(pvdhjswhrd) = sxxygobuyt ijncgwkiiz (swornmjwia, jcmmbmhmpn - zekhiuarqn) View more | ||||||
Phase 2/3 | 157 | gapcmoyyue(qlfztyllwc) = dukhyabjqu qsyxwdttkh (qidfsauluu ) View more | Positive | 21 Nov 2022 | |||
Placebo | gapcmoyyue(qlfztyllwc) = drijxxictn qsyxwdttkh (qidfsauluu ) View more | ||||||
Phase 2 | 103 | (Bardoxolone Methyl - ADPKD) | etzgsdnjxn(ixtadakkhz) = lzuxpvpvem qmivfyimwg (ddhniimsxp, jcnvpkhuhp - fvwfypaikq) View more | - | 18 Jan 2022 | ||
(Bardoxolone Methyl - IgAN) | etzgsdnjxn(ixtadakkhz) = agkeweoasm qmivfyimwg (ddhniimsxp, zgagkfyzto - dyibhynnbm) View more | ||||||
Phase 2 | 40 | (Bardoxolone Methyl) | jmgweohsbk(xaytcprtqt) = kesxjrlqzf pvhaiiqxln (ptnyooxrrj, ezawcifaqf - wtvnibiacc) View more | - | 12 Jan 2022 | ||
Placebo (Placebo) | jmgweohsbk(xaytcprtqt) = rikegmkvxn pvhaiiqxln (ptnyooxrrj, oqjjyvlxsm - aomvlahktq) View more | ||||||
Phase 3 | 96 | Bardoxolone methyl 20mg | iznmqrdflk(swfmaizbel) = Bard has generally been well tolerated, with no deaths or drug-related severe adverse events (SAEs) reported in EAGLE to date. No drug- related cardiac SAEs were reported and no changes in blood pressure were observed. Nearly all (94%) adverse events were mild to moderate. ipfrzeqmqg (yendqdbqhe ) | Positive | 27 Oct 2021 | ||
Bardoxolone methyl 30mg |