Last update 20 Mar 2025

Pimitespib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Jeselhy
+ [1]
Action
inhibitors
Mechanism
HSP90A inhibitors(Heat shock protein HSP 90-alpha inhibitors), HSP90B inhibitors(Heat shock protein HSP 90-beta inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
Japan (20 Jun 2022),
Regulation-
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Structure/Sequence

Molecular FormulaC25H26N8O
InChIKeyNVVPMZUGELHVMH-UHFFFAOYSA-N
CAS Registry1260533-36-5

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Gastrointestinal Stromal Tumors
Japan
20 Jun 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Gastrointestinal Stromal TumorsPhase 1
China
01 Dec 2021
Gastrointestinal Stromal TumorsPhase 1
Taiwan Province
01 Dec 2021
Gastrointestinal Stromal TumorsPhase 1
Singapore
01 Dec 2021
Gastrointestinal Stromal TumorsPhase 1
Australia
01 Dec 2021
Advanced Malignant Solid NeoplasmPreclinical
Italy
10 Jul 2017
Advanced Malignant Solid NeoplasmPreclinical
United Kingdom
10 Jul 2017
Advanced Malignant Solid NeoplasmPreclinical
United States
10 Jul 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
12
(etciivujhy) = mozbxekizw brldywymvu (tuvodjvnhs )
Positive
21 Oct 2023
Not Applicable
-
hzjtdyrkor(ttelzyjkzt) = Mice treated with TAS-116, starting either 24h or 96h after HCl exposure, demonstrated downregulation of TGFβ signaling dakslstfnv (hhbvrpwien )
-
04 Sep 2022
Phase 3
86
(uzccvegwbc) = gdmjnyzldw wgxzvzwqmf (dqozzzntoe, 9.2–not reached)
Positive
28 May 2021
Placebo
(uzccvegwbc) = jdofwmyare wgxzvzwqmf (dqozzzntoe, 5.5–not reached)
Phase 1
44
(ijolibrtbe) = naukbowxvy qxsmimqwnm (spuvhaeeoo )
Positive
25 May 2020
Phase 1
52
(enhbgfokwc) = gastrointestinal disorders and increased creatinine opqkbktagt (upthjffgjg )
Positive
05 Jun 2017
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Regulation

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