Delving into the Latest Updates on Cadi-05 with Synapse

This is a randomized, double blind, two arms, placebo controlled, clinical trial to study to evaluate the the safety and efficacy of Mycobacterium w in combination with standard of care versus placebo with standard of care for preventing the progression of COVID-19 disease and for reduction in transfer to ICU in COVID-19 infected patients admitted to the hospital.

Start Date30 Jun 2020

Sponsor / Collaborator

Cadila Pharnmaceuticals

[+1]

CTRI/2020/04/024846 / CompletedPhase 3

A clinical trial to evaluate the safety and efficacy of Mycobacterium W in critically ill patients suffering from COVID 19 infection

Start Date30 Apr 2020

Sponsor / Collaborator

Cadila Pharmaceuticals Ltd.

100 Clinical Results associated with Cadi-05

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100 Translational Medicine associated with Cadi-05

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100 Patents (Medical) associated with Cadi-05

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353

Literatures (Medical) associated with Cadi-05

01 Oct 2024·Current Opinion in Neurology

Leprous neuropathy

Review

Author: Marques, Wilson

Purpose of reviewLeprosy is still an important cause of neuropathy. Late diagnosis is associated with development of severe nerve impairment.Recent findingsearly diagnosis and early treatment is essential in order to avoid disability and disease transmission. Recognizing that leprosy is a neurological disease is a fundamental step to the Leprosy zero action proposed by the World Health OrganizationSummaryleprosy neuropathy manifests as a mononeuropathy or a multiple mononeuropathy with a temperature-dependent distribution. Electromyography, high-resolution sonography serology and PCR help make the diagnosis. Multidrug therapy should be instituted.

01 Oct 2024·International Journal of Dermatology

Leprosy knowledge among primary care physicians in Southern Brazil: are we underdiagnosing?

Article

Author: de Cássia Francisco, Priscila ; Kliemann, Breno Saty ; Tarlé, Roberto Gomes

AbstractBackgroundLeprosy is a chronic infection with high morbidity in Brazil. Primary care physicians' lack of knowledge about the disease may play a significant role in underdiagnosis. This study aimed to assess primary care physicians' ability to identify typical leprosy skin lesions and their knowledge of the subject.MethodsThis cross‐sectional study relied on a questionnaire in which participating doctors chose one main diagnostic hypothesis and two differential diagnoses for each skin lesion presented. Five leprosy lesions were included. Questions regarding management, follow‐up, and diagnostic workup for the disease were also included. The questionnaire was sent to primary care physicians working in Curitiba, in the Southern Brazilian state of Paraná, and dermatologists, who constituted the control group.ResultsThirty‐two primary care physicians and 26 dermatologists agreed to participate in the study. Primary care physicians accurately identified a mean of 1.8 ± 1.2 of the five leprosy skin lesions, while dermatologists accurately identified 2.5 ± 0.9 (P = 0.009). The main misdiagnosed leprosy forms were the lepromatous and histoid variants. Among primary care physicians, 56.2% claimed to have little knowledge of the subject and a large share of participants was unaware of recent updates in treating paucibacillary forms, even within the dermatologist subgroup.ConclusionsPrimary care physicians in Curitiba have little information regarding the diagnosis, treatment, and follow‐up of leprosy. Even dermatologists had difficulties with treatment and patient management, emphasizing the constant need for education on this subject.

01 Sep 2024·Microvascular Research

Nail fold capillaroscopy in leprosy: Unveiling the microvascular changes

Article

Author: Gandhi, Vijay ; Aggarwal, Amitesh ; Aggarwal, Bharti ; Singal, Archana ; Saha, Sushobhan

BACKGROUNDLeprosy, a chronic infectious disease, is associated with various nail changes. Its etiopathogenesis is multifaceted, with microvascular damage being crucial. Nail fold capillaroscopy (NFC) emerges as a novel tool for detecting early vascular deficits in leprosy. The study aimed to assess and provide a complete clinical characterization of NFC changes in leprosy patients.METHODSIt is an observational cross-sectional study, done over a period of 1.5 year (January 2021 to august 2022) in a tertiary care hospital, encompassing 60 patients diagnosed with leprosy (18-60 years). After obtaining informed consent; detailed history, complete cutaneous and neurological examinations were conducted. All fingernails and toenails were examined for clinical changes. Subsequently, onychoscopy was performed using USB type of video-dermatoscope (Model AM7115MZT Dino-lite), a non-invasive tool. This was followed by NFC which was done for all fingernails and images were recorded by single operator, which were then assessed for quantitative and qualitive changes and statistical analysis was conducted using SPSS v20, with mean capillary density compared using Student's t-test, morphological change frequencies assessed by proportions, and group comparisons made using Chi-square or Fischer exact tests, with a significance threshold of p < 0.05.RESULTSAmong the 60 patients, 39 were in the lepromatous group, which included both borderline lepromatous (BL) and lepromatous leprosy (LL) patients, and 17 were in the tuberculoid group, which included borderline tuberculoid (BT) leprosy patients; 23.3 % had Type 1 reactions, and 18.3 % had Type 2 reactions. Nail fold capillaroscopy (NFC) showed microvasculature changes in 93.3 % of patients. The average capillary density was 6.8 ± 1.5 capillaries per mm, with the lepromatous group having a lower density (6.5 ± 1.09) compared to the tuberculoid group (7.0 ± 0.86). The most common NFC changes in the tuberculoid group were tortuous capillaries (70 %), capillary dropouts, and dilated capillaries (both 64.7 %). In the lepromatous group, capillary dropouts (82 %) were most frequent, followed by tortuous (69 %), receding (69 %), and dilated capillaries (66 %). A dilated and prominent subpapillary plexus was more common in the lepromatous group (35 %, p = 0.04). Patients with trophic changes in the lepromatous group had more capillary dropouts and bizarre capillaries. Capillary dropouts, dilated capillaries, and visible subpapillary venous plexus were more prevalent in patients with Type 2 reactions.CONCLUSIONNFC changes are prevalent in both tuberculoid and lepromatous leprosy, which may be an indicator of peripheral vascular compromise and trophic changes, especially in lepromatous leprosy. NFC can be an auxiliary tool for detecting microvascular abnormalities in leprosy patients.

100 Deals associated with Cadi-05

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KEGG	Wiki	ATC	Drug Bank
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R&D Status

Approved

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Indication	Country/Location	Organization	Date
Leprosy	IN	-	01 Jan 1998
Non-Small Cell Lung Cancer	IN	-	01 Jan 1998

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Melanoma	Phase 1	US	Cadila Pharmaceuticals Ltd.	-
Prostatic Cancer	Phase 1	IN	Cadila Pharmaceuticals Ltd.	-
COVID-19	Preclinical	IN	Cadila Pharmaceuticals Ltd.	14 May 2020
Tuberculosis	Preclinical	IN	Cadila Pharmaceuticals Ltd.	17 Jul 2018
Sepsis	Preclinical	IN	Cadila Pharmaceuticals Ltd.	23 May 2015
Bladder Cancer	Preclinical	IN	Cadila Pharmaceuticals Ltd.	-
Head and Neck Neoplasms	Preclinical	IN	Cadila Pharmaceuticals Ltd.	-
Multiple Myeloma	Preclinical	IN	Cadila Pharmaceuticals Ltd.	-

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


Literature Manual	Phase 1	Astrocytoma \| Glioblastoma \| Testicular Neoplasms \| Bronchogenic Carcinoma \| Bladder Cancer \| Fibrosarcoma \| Head and Neck Neoplasms	24	Cadi-05	ooaxqfihyx(xfvcmktpzz) = xpsapbekwr cezvxejpch (vdmuivvgnw )	Positive	20 May 2008