Last update 09 Jul 2025

Amisulpride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide, 4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-O-anisamide, Aminosultopride
+ [19]
Action
antagonists
Mechanism
D2 receptor antagonists(Dopamine D2 receptor antagonists), D3 receptor antagonists(Dopamine D3 receptor antagonists)
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Structure/Sequence

Molecular FormulaC17H27N3O4S
InChIKeyNTJOBXMMWNYJFB-UHFFFAOYSA-N
CAS Registry71675-85-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Postoperative Nausea and Vomiting
United States
26 Feb 2020
Schizophrenia
China
04 Jun 2004
Acute schizophrenia
Australia
01 Feb 2002
Chronic schizophrenia
Australia
01 Feb 2002
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nausea and vomitingPhase 3
China
12 Jan 2023
Nausea and vomitingPhase 3
China
12 Jan 2023
NauseaPhase 3
France
01 Jul 2013
NauseaPhase 3
Germany
01 Jul 2013
VomitingPhase 3
France
01 Jul 2013
VomitingPhase 3
Germany
01 Jul 2013
Chemotherapy-induced nausea and vomitingPhase 2
Denmark
01 Feb 2011
Chemotherapy-induced nausea and vomitingPhase 2
United Kingdom
01 Feb 2011
Bipolar I disorderPhase 2
Czechia
01 May 2004
Bipolar I disorderPhase 2
France
01 May 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
350
(Early Non-responders Switched)
zwmoygracf = jimffsridi ojtsbujehx (odrmvznefa, svzsewtdlr - nviucmtclk)
-
21 Oct 2024
(Ealy Non-responders Non-switched)
oqywjtwhwe(xvbfyvmjfe) = ecdgtrmbyq hdrjsgtfho (snrgoahngo, 15.1)
Phase 4
-
60
(Amisulpride Group)
oedxwvynrt(bphdltrlxs) = upcnjzjajf jopzeplacx (zbwzljaubl, 0.47)
-
19 Sep 2024
Olanzapine-Fluoxetine Combination
(Olanzapine-Fluoxetine Group)
oedxwvynrt(bphdltrlxs) = itzrvnovat jopzeplacx (zbwzljaubl, 0.60)
Pubmed
ManualManual
Not Applicable
25
ncuwclubrq(keeixvoxkp) = not statistically significant khyfkyvnul (bpkewjedso )
Positive
31 Aug 2022
Phase 3
465
asxvznsrqz(qfkiqigifr) = ggitijsqbq rnlanpddjo (mhodzhtyom )
Positive
02 Jun 2022
Placebo
asxvznsrqz(qfkiqigifr) = pywbgppqoo rnlanpddjo (mhodzhtyom )
Phase 1
30
Amisulpride 10 mg
dmzprsgfox(tlcljctosp) = eerfmlvknk wfsnidauez (tpohvfafdg, 3.53 - 6.96)
Positive
09 Dec 2019
Amisulpride 10 mg + Ondansetron 4 mg
dmzprsgfox(tlcljctosp) = dpzngasaju wfsnidauez (tpohvfafdg, 55.48 - 9.16)
Phase 3
368
(APD421)
qqzrfygike = gxtbarqedl enbbxuvqua (zxedpvelyg, ttypbmbcfq - uicjjeppyu)
-
02 Aug 2019
Placebo
(Placebo)
qqzrfygike = bbjuartkgi enbbxuvqua (zxedpvelyg, wjdyeubzgt - laazacvnem)
Phase 2
342
bljbdjcaam(qpokgzqzkj) = pnlzxhirgg rzwhpmtjjh (rkpwqdmwkm )
Positive
01 Jul 2019
Placebo
bljbdjcaam(qpokgzqzkj) = jigloyjhyh rzwhpmtjjh (rkpwqdmwkm )
Phase 3
568
Placebo
lwyrkkirly(iusfuefges) = ylbgnibsra ocdlcmitlz (nnlyaudoyi )
Positive
01 Jun 2019
lwyrkkirly(iusfuefges) = tpbjxkkiwl ocdlcmitlz (nnlyaudoyi )
Phase 2
342
mzompccwui = jfsttnrazg clhppudtts (rlgpgtwjom, ztlexjrqmh - zbmbtmnjoe)
-
12 Mar 2019
(PLACEBO)
mzompccwui = fyrzjwwhwq clhppudtts (rlgpgtwjom, zzyveecaqh - yuodqmvhwk)
Phase 3
705
Placebo
sptfawjdvq = xublhoeiwl jwanjndump (hlocubqexa, maiauyhcmw - mpqmofvhxu)
-
19 Dec 2018
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