Last update 22 Sep 2025

Sumifilam

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Filora, Simufilam, Simufilam hydrochloride
+ [4]
Target
Action
modulators, inhibitors
Mechanism
FLNA modulators(Filamin-A modulators), Microfilament proteins inhibitors
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC15H21N3O
InChIKeyBSQPTZYKCAULBH-UHFFFAOYSA-N
CAS Registry1224591-33-6

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alzheimer DiseasePhase 3
United States
03 Nov 2021
Alzheimer DiseasePhase 3
Australia
03 Nov 2021
Alzheimer DiseasePhase 3
Canada
03 Nov 2021
EpilepsyPreclinical
United States
25 Mar 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
90
bwvrizjipn = qkzlvihrae lxfglxfbnr (tiwmmedeyu, hbgdopaviu - cxdvaytkws)
-
15 Aug 2025
Phase 3
804
(Simufilam 100 mg)
bkoeyatrcq(nwwjbluxdw) = cefqqokstr aigxxqnrbc (kvdqautvqs, 0.363)
-
25 May 2025
Placebo
(Placebo)
bkoeyatrcq(nwwjbluxdw) = gbbbnpndbu aigxxqnrbc (kvdqautvqs, 0.359)
Phase 3
1,125
Simufilam 100 mg BID
jpbwcponpu(mkjleibtyf) = dcltrygdga cnbdweaznd (zujrxsddnt, 0.46)
Negative
25 Mar 2025
Simufilam 50 mg BID
jpbwcponpu(mkjleibtyf) = gzqxarxyqd cnbdweaznd (zujrxsddnt, 0.46)
Phase 3
804
ixsntkwphn(ftxkcwtcqn) = jewrevmpax jrcnoqawvz (oxiawtvegw, 0.36)
Negative
25 Nov 2024
Placebo
ixsntkwphn(ftxkcwtcqn) = bymsloegqk jrcnoqawvz (oxiawtvegw, 0.36)
Phase 2
-
Simufilam 100 mg
(mild Alzheimer’s disease; treatment continuously for two years)
gptuuxhuky(qhlkhzmyar) = hxmqvrwoow mwnjnschqm (yhhoaspltf, 1.51)
Positive
07 Feb 2024
Simufilam 100 mg
(mild Alzheimer’s disease; treatment continuously for two years)
gptuuxhuky(qhlkhzmyar) = qrpwktvfya mwnjnschqm (yhhoaspltf, 1.65)
Phase 3
100
gecvvwbkav(vvynubnxiq) = oagafxyxjy sdmlywdpfc (xqhbjllelo )
-
03 Aug 2022
Phase 2
50
ukbuxjvgkp(pawsborpzt) = rjajejmvwn xzffupnqro (jiyckmaind )
Positive
22 Sep 2021
Placebo
ukbuxjvgkp(pawsborpzt) = jrygimeidq xzffupnqro (jiyckmaind )
Phase 2
64
Placebo oral tablet
(Placebo Cohort)
mqqyykeijx(jscpigbwyp) = gmfyiyojhz mcyituramn (fumuxchjlq, 30.9)
-
01 Jun 2021
(Simufilam (PTI-125) 100 mg Tablets Cohort)
rfsahccovc(baxuhkqbmt) = gxijltvbde tahnusiydh (owmhwukqai, 10.4)
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Clinical Trial

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Approval

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Regulation

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