Author: Wang, Chirun ; Shang, Xianfeng ; Chong, Hui ; Zhao, Yuchi ; Hu, Xu ; Sun, Haidi ; Cheng, Gong ; Wang, Dong-An ; Zhang, Zhen ; Wu, Zhonglian ; Yang, Jian ; Cong, Bo ; Shi, Junli ; Yao, Hang ; Gu, Zehao

Due to the lack of blood vessels and nerves, the ability of cartilage to repair itself is limited, and the injury of articular cartilage urgently needs effective treatment. Currently, the limitation of clinical repair for cartilage defects is that it is difficult to form pure hyaline cartilage repair, and the source of cartilage tissue and cells is limited. To obtain high-purity regenerated hyaline cartilage, we proposed to construct an injectable hydrogel precursor by using human living hyaline cartilage graft (hLhCG) secreted by human chondrocytes as the dispersed phase and fibrinogen solution as the continuous phase, by double injection with thrombin, three-dimensional network hydrogel structure was formed under the action of thrombin to repair joint defects. The component phenotypes of hLhCG and biomechanical properties of composite gel scaffolds were verified. After 12 weeks of injection of the mixed phase at the defect site, the regenerated tissues are similar in composition to adjacent natural tissues and exhibit similar biomechanical properties. The phenotype of regenerated cartilage was verified, confirming the successful regeneration of hyaline cartilage.

31 Dec 2024·Future Science OA

Effect of aspirin on platelet-rich plasma of diabetes mellitus with lower extremity atherosclerosis

Article

Author: Zhang, Jiajia ; Li, Tao ; Cao, Zhengwang ; Liu, Wanbing ; Yue, Ling ; Xiang, GuangDa ; Shang, Shenglan ; Hu, Fan ; Cheng, Yangyang

Aim: Platelet-rich plasma (PRP), enriched with multiple growth factors, is a promising adjunctive therapy for diabetic foot ulcers (DFUs). As a classic anti-platelet drug for diabetic patients, the effects of aspirin on the content of growth factors in PRP remains unclear.Methods: Our study enrolled diabetic patients who were currently taking or not taking aspirin as the research subjects, with healthy volunteers as the control. PRP from these individuals was activated with glucose calcium and thrombin. Growth factors levels in PRP activated supernatant (PRP-AS) and wound healing ability of platelet gel (PG) in the full-thickness skin defect diabetic mouse model were compared.Results: We found the level of growth factors in PRP-AS derived from two groups of diabetic patients were not statistically different, whereas both lower than that from healthy volunteers. Similarly, we found better wound healing ability of PG from healthy volunteers than those from diabetic patients, but no difference between the two groups of diabetic patients in the mouse model.Discussion: Aspirin does not interfere with autologous PRP therapy when using calcium gluconate and thrombin as agonists. However considering the content of growth factors, PRP from healthy volunteers is a preferable option for promoting DFU repair.

01 Dec 2024·Radiology Case Reports

Pseudoaneurysm formation following core needle biopsy in a patient diagnosed with breast cancer: A case report

Article

Author: Al Mazrouai, Reem Ahmed ; Al Shizawi, Asma ; Al Qassabi, Badriya ; Al Aghbari, Suaad

Core needle biopsy is a common diagnostic procedure in breast cancer patients, but it can occasionally lead to serious complications. We report a rare case of pseudoaneurysm formation following a core needle biopsy in a 54-year-old female patient diagnosed with breast cancer. Despite the routine nature of the procedure, the patient developed a palpable mass at the biopsy site, which prompted further diagnostic imaging and interventions. The pseudoaneurysm was effectively treated using a percutaneous approach with ultrasound-guided thrombin injection, demonstrating a minimally invasive solution that promptly addressed the complication without the need for surgical intervention. This case highlights the critical importance of detecting complications early in the biopsy process, as they have significant implications for disease staging and treatment initiation. It also underscores the importance of being prepared for immediate intervention in case of biopsy-related complications like pseudoaneurysms, to prevent severe consequences.

100 Deals associated with Liquid Thrombin MOCHIDA

R&D Status

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Hemorrhage	JP	Mochida Pharmaceutical Co., Ltd.	15 Apr 2003

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


UEGW	Not Applicable	Esophageal and Gastric Varices	-	EUS-guided coil embolisation with thrombin injection	wxzdiftdjt(pughtmozzh) = 1 patient died within 3 months of procedure secondary to hepatic decompensation xvdgncphov (xfdaepenwe ) View more	-	01 Oct 2018
EHA2017	Not Applicable	-	-	Fibrinogenase from <em>Adamussium colbecki</em>	(ywprlmppyz) = ydamrmjmfw eeaaqjnkhi (ezxttjuhjo ) View more	-	18 May 2017
				Control (no fibrinogenase)	(ywprlmppyz) = vobloybpwv eeaaqjnkhi (ezxttjuhjo ) View more
Pubmed \| J Burn Care Res	Phase 3	Burns	138	Fibrin Sealant containing 4 IU/ml thrombin (FS 4IU VH S/D)	tkujvejbsg(ghnnqqyajs) = pxgtforyrb mbqghbdjcb (wdyxhrcrua ) View more	Positive	01 Mar 2008
				Fibrin Sealant	tkujvejbsg(ghnnqqyajs) = eyqpectkmz mbqghbdjcb (wdyxhrcrua ) View more

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Liquid Thrombin MOCHIDA

Overview

Basic Info

Structure/Sequence

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation