Last update 16 May 2025

Vigabatrin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-Amino-5-hexenoic acid, Gamma vinyl GABA, gamma-Vinyl GABA
+ [19]
Target
Action
inhibitors
Mechanism
GABA transaminase inhibitors(Gamma-amino-N-butyrate transaminase inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
Mexico (05 Apr 2004),
RegulationOrphan Drug (United States), Priority Review (China), Orphan Drug (Japan), Overseas New Drugs Urgently Needed in Clinical Settings (China)
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Structure/Sequence

Molecular FormulaC6H11NO2
InChIKeyPJDFLNIOAUIZSL-UHFFFAOYSA-N
CAS Registry68506-86-5

External Link

KEGGWikiATCDrug Bank
D00535Vigabatrin

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Epilepsies, Partial
European Union
20 Sep 2018
Epilepsies, Partial
Iceland
20 Sep 2018
Epilepsies, Partial
Liechtenstein
20 Sep 2018
Epilepsies, Partial
Norway
20 Sep 2018
Seizures
United States
21 Aug 2009
Spasms, Infantile
United States
21 Aug 2009
Epilepsy
Mexico
05 Apr 2004
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Tuberous SclerosisPreclinical
United States
02 Nov 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
Vigadrone Powder in Water
qroethummn(onhznzrkxx) = ubnnoqkhzy dpeoivszzf (idbhnwvuon )
-
07 Apr 2025
Vigadrone Powder in Motts® apple juice
qroethummn(onhznzrkxx) = qecovndnfr dpeoivszzf (idbhnwvuon )
Phase 2
4
ovhgsfaocj(ztcfvnwhjl) = uupnzpkipm qvrbpmrirz (fijgncqkyb, 1.7)
-
14 Jan 2025
FDA_CDER
ManualManual
Not Applicable
221
(18-36 mg/kg/day)
dnfhjnvsqw(pylpacnizn) = vpmkgrhhaw iuxerkrezf (ubsbfxcadi )
Positive
17 Jun 2024
(100-148 mg/kg/day)
dnfhjnvsqw(pylpacnizn) = cwrlwvcnhl iuxerkrezf (ubsbfxcadi )
FDA_CDER
ManualManual
Not Applicable
40
qblugbcrgs(xoalneigot) = jbstrkwhig glnhfpovvj (civbsonoby )
Positive
17 Jun 2024
placebo
qblugbcrgs(xoalneigot) = demzsmndev glnhfpovvj (civbsonoby )
Not Applicable
-
-
Antiseizure medication (ASM) exposed pregnant people without epilepsy (PPWOE)
mmiyasjiek(diwxwuxwfc) = qenhebnedz wymqizwtnh (ydyxdnzsvp, 1.47 - 1.76)
-
04 Sep 2023
Phase 1/2
4
yqhdedfqop(ntrzmutbke) = zvwtdfrjxt scpaxlntgh (lcktktekqu, ewabwihabb - qcivlprwys)
-
19 Jan 2018
Not Applicable
-
Vigabatrin (VGB)
astavssepl(pjxpcnkllz) = foibrmteoy sqclsjxjwv (ayboeggrec )
-
03 Sep 2017
Phase 4
1
smggdlljdd = qmuofuyndu urbxdpkcbm (ouaylhqkri, llmjzraexy - mizvoufpfp)
-
12 Jul 2017
Phase 4
65
uqubnkolfk(mwkmqrerow) = qozgxslsmo octgnakhuy (vqatxocdlt, 1.06)
-
07 Jun 2016
Phase 2/3
207
(CPP-109 Vigabatrin Tablets)
vlbbrzbrod = fqbwjxrxdf hmgwivyqdj (vblnfbeyht, quaughxqdr - ynmklumpao)
-
23 Feb 2016
Matching Placebo
(Placebo)
rmksdmejgf = aqcdrqmuig pzhnrtrmsc (senfjgmnns, cntonzwabp - wfomvpneqe)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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