Last update 20 Mar 2025

AND-017

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(8'-hydroxy-6'-oxo-3'-phenyl-6'H-spiro[cyclopentyl-1,5'-indolazine]-7'-carbonyl) glycine, AND017
+ [1]
Action
inhibitors, stimulants
Mechanism
HIF-PHs inhibitors(Hypoxia-inducible factor prolyl hydroxylase inhibitors), Hemoglobins stimulants
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC23H35NO2
InChIKeyZZMJTNMGPPBIOY-CLGWBQSRSA-N
CAS Registry159325-45-8

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Myelodysplastic SyndromesPhase 2
China
03 Dec 2024
AnemiaPhase 2-01 Dec 2024
myelodysplastic anemiaPhase 2-01 Dec 2024
Beta-ThalassemiaPhase 2
China
27 May 2024
chronic renal failure anemiaPhase 2
United States
30 Jan 2022
Chronic nephritisPhase 2
China
04 Nov 2021
Anemia, Sickle CellPreclinical
United States
24 Oct 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
174
AND017(10 mg TIW/16 mg QW)
(miizlmunbk) = rywobkhdpf urapemhtdl (qaxablueii )
Positive
28 Oct 2024
erythropoietin stimulating agents (ESA)
(miizlmunbk) = xzjphbrqkf urapemhtdl (qaxablueii )
Phase 2
113
AND017(8 mg, 12 mg, 16 mg)
(urjariijoj) = yxodzglmnw vqzjbqasdv (zyudbgqvfr )
Positive
28 Oct 2024
Placebo
(urjariijoj) = dyxmapsvuj vqzjbqasdv (zyudbgqvfr )
Phase 1
-
-
AND017 10mg
(Fed)
(fvciocfvkl) = ahfxwydkqf xfgquxzglm (ezwuvurwnq )
Positive
28 Oct 2024
AND017 10mg
(Fasted)
-
Phase 1
-
78
(xjakivavlg) = ipupykqkuw kjwphdikfa (rdnvmbjafm )
Positive
24 Oct 2024
placebo
-
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Regulation

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