NTQ5082

【Main research objectives】 (1) To quantitatively analyze the total radioactivity in the excreta of male healthy subjects after a single oral administration of [14C] NTQ5082, and obtain the data on the excretion rate of radioactivity in the human body and the main excretion pathway; (2) To quantitatively analyze the radioactive metabolite profiles in human plasma, urine and feces after a single oral administration of [14C] NTQ5082 in male healthy subjects, identify the main metabolites, and determine the metabolic pathways and elimination pathways of NTQ5082 in the human body; (3) To quantitatively analyze the total radioactivity in whole blood and plasma after a single oral administration of [14C] NTQ5082 in male healthy subjects, obtain the pharmacokinetic parameters of the total radioactivity in plasma and whole blood (if applicable), and investigate the distribution of the total radioactivity in whole blood and plasma. 【Secondary study objectives】 (1) To quantitatively analyze the concentration of NTQ5082 and its metabolites (if applicable) in plasma using a validated liquid chromatography tandem mass spectrometry (LC-MS/MS) method, and then evaluate the pharmacokinetic parameters of NTQ5082 and its metabolites (if applicable) in plasma; (2) To observe the safety of subjects after a single dose of [14C] NTQ5082.