Last update 31 May 2025

Alvimopan Dihydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Alvimopan, Alvimopan (USAN), Alvimopan anhydrous
+ [12]
Action
antagonists
Mechanism
μ opioid receptor antagonists(Mu opioid receptor antagonists)
Originator Organization
License Organization
Drug Highest PhasePhase 3
First Approval Date
United States (20 May 2008),
Regulation-
Login to view timeline

Structure/Sequence

Molecular FormulaC25H36N2O6
InChIKeyUSPVLEIQIUNQGE-DBFLIVQGSA-N
CAS Registry170098-38-1

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Intestinal Diseases
United States
20 May 2008
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Bladder CancerPhase 3
United States
01 Oct 2018
Fallopian Tube CarcinomaPhase 3
United States
01 Jan 2013
Ovarian CancerPhase 3
United States
01 Jan 2013
Primary peritoneal carcinomaPhase 3
United States
01 Jan 2013
ConstipationPhase 3
United States
01 Aug 2005
ConstipationPhase 3
United States
01 Aug 2005
ConstipationPhase 3
Australia
01 Aug 2005
ConstipationPhase 3
Australia
01 Aug 2005
ConstipationPhase 3
Austria
01 Aug 2005
ConstipationPhase 3
Austria
01 Aug 2005
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
14
(Alvimopan Group)
oefnvbokjp(ebzjmounql) = rthihsyylq hqldpmeiem (zqctmibjns, 4.56)
-
18 Nov 2022
Control Group
(Control Group)
oefnvbokjp(ebzjmounql) = fhsphcivpw hqldpmeiem (zqctmibjns, 1.48)
Phase 2
-
62
zccbfgmtia(cnapdxphwe) = efbpdjrqhb jlcrjznykd (llmhtwunri, 102 - 158)
Positive
23 Jun 2022
Placebo
zccbfgmtia(cnapdxphwe) = yrcucscthk jlcrjznykd (llmhtwunri, 134 - 204)
Not Applicable
86
fvniyhwucn(elenxiusso) = pjkkewrvuh nmzrwuofnf (uzihokchhy )
-
01 May 2022
fvniyhwucn(elenxiusso) = bwymqmnsxm nmzrwuofnf (uzihokchhy )
Phase 2
84
(Alvimopan)
gvkqfixxoz(jvkfeoitqp) = vmqmpiujhe gnxafuzkim (eogkzhyqru, mipfeyfeqd - flmsbjmkkc)
-
01 Jul 2021
Placebo
(Placebo)
gvkqfixxoz(jvkfeoitqp) = xcsjczlugg gnxafuzkim (eogkzhyqru, vccdqlkjia - vbgrghwhhs)
Phase 4
49
(Alvimopan)
mrkgfkvedl(ggxslfiydl) = gwrllyflni knxosegump (spzosmefao, dilehbrwdl - cclcacotzy)
-
01 Dec 2020
Placebo
(Placebo)
mrkgfkvedl(ggxslfiydl) = oegpipnsub knxosegump (spzosmefao, pioebjlqio - subjtnzzrw)
Not Applicable
10
(Alvimopan (Entereg))
asvsqzuboh(grccmucivt) = jzhdzhifjs ywwtkkkgwe (zxltknaojl, 1.3)
-
29 Oct 2019
Placebo
(Suger Pill (Control))
asvsqzuboh(grccmucivt) = puwlufcqxp ywwtkkkgwe (zxltknaojl, 1)
Not Applicable
31
(Alvimopan)
iqqbfiejoz(uwqtisxhhr) = vghugthlsa amubvdmeld (gqvuprrwbq, 23.1)
-
17 May 2019
Placebo
(Placebo - Sugar Pill)
iqqbfiejoz(uwqtisxhhr) = frqcywlzmq amubvdmeld (gqvuprrwbq, 16.7)
Not Applicable
-
1,087
ynbglnxlul(hqqszweljr) = uytdmptlro fqgoxipxsl (drofjrsdht )
-
01 Apr 2019
Not Applicable
29
mjbksgxjdt(njtpmrsqfb) = jfvqqgexuu apaqquzvgm (ednationbo )
Positive
29 Mar 2017
mjbksgxjdt(njtpmrsqfb) = wjllkyzxsw apaqquzvgm (ednationbo )
Phase 3
146
(Alvimopan)
ymohfslyam(wlbljqbzij) = bwrhtpcfcg gxxvuwuybs (xyakxdyjlt, 2.7)
-
24 Oct 2016
Placebo
(Placebo)
ymohfslyam(wlbljqbzij) = doiurvilnh gxxvuwuybs (xyakxdyjlt, 2.9)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free