Last update 17 Mar 2026

JRF-104

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
JRF 104, JRF104, XH-30002
Target
AXL x CDK4 x CDK6 x FLT3
Action
inhibitors
Mechanism
AXL inhibitors(AXL receptor tyrosine kinase inhibitors), CDK4 inhibitors(Cyclin-dependent kinase 4 inhibitors), CDK6 inhibitors(Cyclin-dependent kinase 6 inhibitors)
Therapeutic Areas
NeoplasmsDigestive System DisordersHemic and Lymphatic Diseases
Active Indication
Advanced Malignant Solid NeoplasmEsophageal CarcinomaAcute Myeloid Leukemia
Inactive Indication-
Originator Organization
Chengdu Jinruijiye Biotechnology Co., LtdChengdu Jinruijiye Biotechnology Co., Ltd
Active Organization
Chengdu Jinruijiye Biotechnology Co., LtdChengdu Jinruijiye Biotechnology Co., LtdShanghai Xunhe Pharmaceutical Technology Co., LtdShanghai Xunhe Pharmaceutical Technology Co., Ltd
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

3
Clinical Trials associated with JRF-104
NCT05927844
/ Not yet recruitingPhase 1IIT
An Open, Single-arm, Multicenter Phase Ib Clinical Study of XH-30002 Capsule Combined With Afatinib Tablets for the Treatment of Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma
CTR20202519
/ RecruitingPhase 1
一项评价XH-30002胶囊口服给药在晚期实体瘤患者中的安全性、耐受性、药代动力学特征和初步疗效的Ⅰ期临床研究
[Translation] A Phase I clinical study to evaluate the safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of oral XH-30002 capsules in patients with advanced solid tumors
ChiCTR2100043865
/ RecruitingPhase 1IIT
A phase I clinical study evaluating the safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of XH-30002 capsules administered orally in patients with advanced solid tumors
100 Clinical Results associated with JRF-104
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100 Translational Medicine associated with JRF-104
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100 Patents (Medical) associated with JRF-104
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100 Deals associated with JRF-104
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 1
China
Shanghai Xunhe Pharmaceutical Technology Co., LtdShanghai Xunhe Pharmaceutical Technology Co., Ltd
01 Dec 2020
Esophageal CarcinomaPreclinical
China
Chengdu Jinruijiye Biotechnology Co., LtdChengdu Jinruijiye Biotechnology Co., Ltd
15 Aug 2024
Acute Myeloid LeukemiaPreclinical
China
Chengdu Jinruijiye Biotechnology Co., LtdChengdu Jinruijiye Biotechnology Co., Ltd
15 Aug 2020
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Clinical Result

Indication
Phase
Evaluation
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Clinical Trial

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Approval

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Regulation

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