[Translation] To evaluate the safety and tolerability and pharmacokinetics of XH-6003 injection in a randomized, double-blind, single-center, placebo-controlled, dose-escalation phase 1 study of a single dose in healthy Chinese adult subjects clinical research
(1)评估XH-6003注射液在中国健康受试者中单次给药的安全性和耐受性,确定最大耐受剂量。
(2)考察XH-6003注射液在中国健康受试者中单次给药后的XH-6003和XH-6003主要代谢产物(XH-6003-M)的药代动力学(PK)及药效学(PD)特征。
[Translation] (1) To evaluate the safety and tolerability of a single dose of XH-6003 injection in Chinese healthy subjects, and to determine the maximum tolerated dose.
(2) To investigate the pharmacokinetics (PK) and pharmacodynamics of XH-6003 and the main metabolite (XH-6003-M) of XH-6003 injection in Chinese healthy subjects after single administration Science (PD) characteristics.