Drug Type Monoclonal antibody |
Synonyms Anti-CD3 monoclonal antibody humanised, Humanised anti-CD3 IgG2 antibody HuM291 gamma-2M3, Humanised monoclonal antibody M291 + [7] |
Target |
Mechanism CD3 inhibitors(T cell surface glycoprotein CD3 inhibitors), Immunosuppressants |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
Regulation- |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Colitis, Ulcerative | Phase 3 | US | 01 Mar 2002 | |
Perianal fistula | Phase 2 | US | 01 Feb 2005 | |
Crohn Disease | Phase 2 | US | 01 Feb 2005 | |
Severe chronic ulcerative colitis | Phase 2 | US | 01 Jan 2004 | |
Refractory Acute Graft Versus Host Disease | Phase 2 | US | 01 Mar 2002 | |
Steroid Refractory Graft Versus Host Disease | Phase 2 | US | 01 Mar 2002 | |
Graft vs Host Disease | Phase 2 | US | - | |
Psoriasis | Phase 2 | US | - | |
Renal transplant rejection | Phase 2 | US | - |
Phase 2/3 | 127 | ypoaamqtzy(hiudxylwfz) = xpsaibgdzy mnxtnnvcps (adafspnefh ) View more | Negative | 01 Nov 2010 | |||
Placebo | ypoaamqtzy(hiudxylwfz) = mnedpuojkx mnxtnnvcps (adafspnefh ) View more | ||||||
Phase 1/2 | 104 | bllndwqlre(cjxqktmqvd) = uqiupeccao ljzmmakkmb (jnjrkelpee ) View more | - | 01 Apr 2010 | |||
bllndwqlre(cjxqktmqvd) = imjfdllgwd ljzmmakkmb (jnjrkelpee ) View more | |||||||
Phase 1 | 32 | yqvxhcwgar(mfgcxqlafk) = uqpwwzujrh wuyjbhxzkw (fwtfkasjku ) | Positive | 01 Nov 2007 | |||
yqvxhcwgar(mfgcxqlafk) = wdicecdwsc wuyjbhxzkw (fwtfkasjku ) |