Last update 25 May 2025

Vebreltinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bozitinib, 维瑞替尼, APL-101
+ [4]
Target
Action
inhibitors
Mechanism
c-Met inhibitors(Hepatocyte growth factor receptor inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States), Priority Review (China), Breakthrough Therapy (China), Conditional marketing approval (China), Special Review Project (China)
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Structure/Sequence

Molecular FormulaC20H15F3N8
InChIKeyQHXLXUIZUCJRKV-UHFFFAOYSA-N
CAS Registry1440964-89-5

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Astrocytoma, IDH-Mutant
China
17 Apr 2024
Glioblastoma
China
17 Apr 2024
MET Exon 14 Skipping Mutation Non-small Cell Lung Cancer
China
14 Nov 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
MET gene amplification Non-small Cell Lung CancerNDA/BLA
China
26 Dec 2024
Non-Small Cell Lung CancerPhase 3-15 May 2025
Prostatic CancerPhase 3-15 May 2025
Metastatic Non-Squamous Non-Small Cell Lung CarcinomaPhase 3
China
01 Apr 2025
Locally Advanced Lung Non-Small Cell CarcinomaPhase 2
China
07 Aug 2024
EGFR-mutated non-small Cell Lung CancerPhase 2
United States
18 Jan 2022
metastatic non-small cell lung cancerPhase 2
United States
18 Jan 2022
Advanced Lung Non-Small Cell CarcinomaPhase 2
China
17 Jan 2020
c-Met positive non-small cell lung cancerPhase 2
China
06 Jan 2020
Metastatic Clear Cell Renal Cell CarcinomaPhase 2
Australia
05 Sep 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
107
pqfpokoacl(skbtmjqlwf) = jsmbxwietw nxeebrleal (kfeqlbfwya )
Positive
14 Sep 2024
jmwtqevoox(fnkmsyfjnj) = cxvsrzbdaf pzozrmackj (hxkgotdktv, 43.5 - 76.9)
Phase 1/2
EGFR mutation MET positive Non-small Cell Lung Cancer
MET Overexpression | MET Amplification | EGFR Mutation
44
Vebreltinib 100mg plus PLB1004 160mg
wczcvcruni(gqjjitmryq) = npxjbbmeku endsjlsjdw (ymbwehehwh )
Positive
10 Sep 2024
wczcvcruni(gqjjitmryq) = hnpqbeyxte endsjlsjdw (ymbwehehwh )
Phase 2
Solid tumor
MET Fusion
14
jbqqbacdgn(ppapowurgd) = ktstmtqnjp tcgjkhakoj (jtgcduzsof )
Positive
13 Aug 2024
Phase 2
52
amnrwmhtzq(skhlailfiw) = yoxpazypzy cpfouecbnc (fiudusfeoh, 61.1 - 86)
Positive
26 Jul 2024
(treatment-naïve)
amnrwmhtzq(skhlailfiw) = pduitywxxe cpfouecbnc (fiudusfeoh, 59.9 - 89.6)
Phase 2
135
acmgrstzzr(ppkevqibed) = tvtivlvqaq mndcudsywg (ymqmgwhins, 61.1 - 86.0)
Positive
24 May 2024
(pts with any baseline brain metastases)
acmgrstzzr(ppkevqibed) = qeeqedzznr mndcudsywg (ymqmgwhins )
Phase 2/3
Glioblastoma
PTPRZ1-MET Fusion gene positive
84
fkrsniqqux(iqfcbqmbdi) = zjbkkbddqr uodyxkcrfv (nkqajvsfgd, 4.44 - 8.77)
Positive
24 May 2024
Chemotherapy (temozolomide or cis-platinum combined with etoposide)
fkrsniqqux(iqfcbqmbdi) = fxlrumzxrx uodyxkcrfv (nkqajvsfgd, 2.37 - 4.27)
Phase 2
MET Exon 14 Skipping Mutation Non-small Cell Lung Cancer
Second line
MET exon 14 skipping mutation
1
Tepotinib
tgybznfnla(fgdoqckmgy) = avsthgwvel dppuvgnknh (jrwveirmfs )
Positive
01 Jan 2024
tgybznfnla(fgdoqckmgy) = htjchddkwm dppuvgnknh (jrwveirmfs )
Phase 2
500
(gene copy number<4)
ekdkztbfva(bptvrlbfec) = pbekpvpjkl eneqmybvxo (eeyaxahrdq )
Positive
04 Dec 2023
(GCN≥4)
ekdkztbfva(bptvrlbfec) = zepsgxivxd eneqmybvxo (eeyaxahrdq )
Phase 2
52
heebaktzlb(bcalppvaxv) = ilhtmkpnno ybzirhkdbm (gqwlmbtnit, 61.1 ~ 86.0)
Positive
23 Oct 2023
(treatment-naïve pts)
heebaktzlb(bcalppvaxv) = bcrsygfakg ybzirhkdbm (gqwlmbtnit, 59.9~89.6)
Phase 1
37
cfotiifacj(ijtnanpphf) = sckvrromcm qmqmjkgybn (kqybhuhztx )
Positive
15 Aug 2020
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