Last update 06 Nov 2024
CBP-1008
Last update 06 Nov 2024
Overview
Basic Info
Drug Type Peptide drug conjugates |
Synonyms CBP 1008, CBP1008 |
Target |
Mechanism FOLR1 agonists(Folate receptor alpha agonists), TRPV6 antagonists(Transient receptor potential cation channel subfamily V member antagonists), Tubulin inhibitors |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 2/3 |
First Approval Date- |
RegulationFast Track (US) |
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Structure
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Related
4
Clinical Trials associated with CBP-1008评价注射用CBP-1008在叶酸受体α（FRα）阳性的铂耐药晚期上皮性卵巢癌、原发性腹膜癌和输卵管癌患者中的疗效和安全性的开放标签、多中心Ⅱ期单臂研究
[Translation] An open-label, multicenter, phase II, single-arm study to evaluate the efficacy and safety of CBP-1008 for injection in patients with folate receptor α (FRα)-positive, platinum-resistant advanced epithelial ovarian cancer, primary peritoneal cancer, and fallopian tube cancer
多中心、开放、评价注射用 CBP-1008 周疗方案在 FOLR1 和/或 TRPV6 表达阳性的晚期恶性实体瘤患者中安全性、耐受性和药代动力学特征以及在选定适应症中扩展的 Ia、Ib 期研究
[Translation] A multicenter, open-label, Phase Ia and Ib study to evaluate the safety, tolerability, and pharmacokinetic characteristics of an 8-week treatment regimen of CBP-100 for injection in patients with advanced malignant solid tumors that are positive for FOLR1 and/or TRPV6 expression, and to expand in selected indications
评价注射用CBP-1008在晚期恶性实体瘤患者中安全性、耐受性、药代动力学特征和在选定适应症中扩展的Ia、Ib期研究
[Translation] Phase Ia and Ib studies to evaluate the safety, tolerability, pharmacokinetic characteristics and expansion of CBP-1008 for injection in patients with advanced malignant solid tumors in selected indications
100 Clinical Results associated with CBP-1008
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100 Translational Medicine associated with CBP-1008
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100 Patents (Medical) associated with CBP-1008
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100 Deals associated with CBP-1008
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Breast Cancer | Phase 3 | CN | - | |
| Ovarian Cancer | Phase 3 | CN | - | |
| Platinum-Resistant Epithelial Ovarian Carcinoma | Phase 2 | CN | 15 Feb 2023 | |
| Platinum-Resistant Fallopian Tube Carcinoma | Phase 2 | CN | 15 Feb 2023 | |
| Platinum-Resistant Primary Peritoneal Carcinoma | Phase 2 | CN | 15 Feb 2023 | |
| Advanced Malignant Solid Neoplasm | Phase 1 | CN | 06 Mar 2019 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
NCT04740398 (ASCO2023) Manual  | Phase 1 | 82 | (platinum-resistant ovarian cancer (PROC)) | udwxjnzxhh(zficqujlnf) = Majority of adverse events were mild to moderate. Grade 3/4 treatment-emerging adverse events (TEAEs) occurred in ≥ 3% subjects were neutropenia (n=85), decreased leukocyte count (n=49), anaemia (n=10), AST elevation (n=7), ALT elevation (n=7). evrljfdvgu (kdugvkweup ) View more | Positive | 31 May 2023 | |
(FRα expression ≥25% and ≤3 prior treatment regimens (PROC)) | |||||||
Phase 1 | 106 | phdagfvtjw(iyhouknqum) = not observed nxldmpgunr (ymckoelfms ) | Positive | 02 Jun 2022 |
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