Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and is caused by mutations in the PKD1 or PKD2 genes, which encode polycystins 1 and 2. Patients develop renal cysts associated with a progressive decline in kidney function, ultimately leading to end-stage renal disease in approximately one third of cases. ADPKD is also characterized by early-onset hypertension and cardiovascular complications, notably intracranial aneurysms.
This phenotype is related to abnormal polycystin function in the primary cilia of renal epithelial and vascular endothelial cells, resulting in impaired mechanotransduction of shear stress induced by urinary and blood flow and subsequent alterations in multiple cellular functions. Experimental studies have suggested that stimulation of dopamine receptor type 5 (DR5) may restore endothelial mechanosensitivity. This hypothesis is supported by our preliminary results showing that local administration of dopamine improves endothelial function in patients with ADPKD through restoration of nitric oxide (NO) release in response to increased blood flow.
Consistent with these findings, the IMPROVE-PKD study recently demonstrated similar beneficial effects on endothelial function and hemodynamics using rotigotine, a dopamine agonist administered via transdermal patches for two months at a low dose (4 mg/24 h). Dopaminergic stimulation may also prevent renal abnormalities related to polycystin deficiency. We therefore hypothesize that rotigotine could slow the progression of ADPKD at both the renal and cardiovascular levels.
This phase 2 study aims to evaluate the long-term tolerability of rotigotine in patients with ADPKD and to collect preliminary data on its effects on renal outcomes.

Start Date01 Mar 2026

Sponsor / Collaborator-

CTR20254138

/ CompletedNot Applicable

罗替高汀贴片在中国受试者外用条件下单中心、随机、开放、单剂量、两制剂、两周期、两序列交叉设计空腹给药人体生物等效性研究

[Translation] A single-center, randomized, open-label, single-dose, two-formulation, two-period, two-sequence crossover design bioequivalence study of rotigotine patch administered on an empty stomach in Chinese subjects under topical conditions

本试验旨在研究单次空腹使用杭州朱养心药业有限公司研制、生产的罗替高汀贴片﹝4.5 mg/10 cm2，（释药量2 mg/24 h）﹞的药代动力学特征；以UCB Pharma S.A.持证、LTS Lohmann Therapie-Systeme AG生产的罗替高汀贴片〔Neupro®/优普洛®，4.5 mg/10 cm2（释药量2 mg/24 h）〕为参比制剂，比较两制剂中药动学参数Cmax、AUC0-t、AUC0-∞，评价两制剂的人体生物等效性，并考察受试制剂和参比制剂在用药过程中的安全性、粘附性和皮肤刺激性。

[Translation]

This study aimed to investigate the pharmacokinetic characteristics of a single fasting dose of a rotigotine patch (4.5 mg/10 cm², 2 mg/24 h release) developed and produced by Hangzhou Zhuyangxin Pharmaceutical Co., Ltd. Using a rotigotine patch (Neupro®, 4.5 mg/10 cm², 2 mg/24 h release) licensed by UCB Pharma S.A. and produced by LTS Lohmann Therapie-Systeme AG as the reference preparation, the pharmacokinetic parameters Cmax, AUC0-t, and AUC0-∞ of the two preparations were compared to evaluate their bioequivalence in humans. The safety, adhesion, and skin irritation of the test and reference preparations during use were also investigated.

Start Date22 Oct 2025

Sponsor / Collaborator

Hangzhou Zhuyangxin Pharmaceutical Co. Ltd.

CTR20253700

/ CompletedNot Applicable

罗替高汀贴片人体生物等效性研究

[Translation] Bioequivalence study of rotigotine patch in healthy volunteers

主要目的：比较湖南派格兰药业有限公司提供的罗替高汀贴片（规格：4.5 mg/10 cm2（释药量2 mg/24 h））与UCB Pharma S.A.持证的罗替高汀贴片（商品名：NEUPRO®（优普洛）®；规格：4.5 mg/10 cm2（释药量2 mg/24 h））在中国健康人群吸收程度和吸收速度的差异，评价两制剂的生物等效性。次要目的： 1）评价受试制剂与参比制剂在中国健康参与者中的安全性；2）评价受试制剂与参比制剂在中国健康参与者用药过程中的黏附性；3）评价受试制剂与参比制剂对中国健康参与者的皮肤刺激性。

[Translation]

Primary Objectives: To compare the extent and rate of absorption of the rotigotine patch (strength: 4.5 mg/10 cm² (drug release: 2 mg/24 h)) provided by Hunan Pageland Pharmaceutical Co., Ltd. and the rotigotine patch (trade name: NEUPRO®; strength: 4.5 mg/10 cm² (drug release: 2 mg/24 h)) licensed by UCB Pharma S.A. in healthy Chinese subjects, and to evaluate the bioequivalence of the two formulations. Secondary Objectives: 1) To evaluate the safety of the test formulation and the reference formulation in healthy Chinese subjects; 2) To evaluate the adhesiveness of the test formulation and the reference formulation during use in healthy Chinese subjects; and 3) To evaluate the skin irritation of the test formulation and the reference formulation in healthy Chinese subjects.

Start Date11 Oct 2025

Sponsor / Collaborator

Hunan Paiglan Pharmaceutical Co., Ltd.

100 Clinical Results associated with Rotigotine

100 Translational Medicine associated with Rotigotine

100 Patents (Medical) associated with Rotigotine

743

Literatures (Medical) associated with Rotigotine

01 Jan 2026·Case reports in dermatological medicine

Autoimmunity to Collagen XVII (BP180-Ag2) in Pemphigoid Associated With Parkinson's Disease.

Article

Author: Herrera-Esparza, Rafael ; Avalos-Diaz, Esperanza ; Ornelas-Ramírez, Ingrid-Gabriela ; Cid-Puente, Ricardo ; Bollain-Y-Goytia, Juan-José ; González-Herrera, Lorena

The association between Parkinson's disease and autoimmune disease is rare; in our population, there is 1 case per 10,000 inhabitants. Bullous pemphigoid has a much lower incidence, and consequently, the association of Parkinson's disease and bullous pemphigoid is rarer. We present the case of an 84-year-old patient with a 16-year history of Parkinson's disease, treated with rotigotine, levodopa, and carbidopa. The patient spontaneously developed tense blisters that spread to the trunk and extremities within 1 year of the first occurrence of dermatological symptoms. A lesional biopsy revealed a subepidermal blister with inflammatory infiltrates, and immunofluorescent evaluation of the biopsy revealed immune deposits of IgG at the basement membrane. The serum displayed antibasement membrane autoantibodies that reacted with monkey esophagus tissue, and immunofluorescence revealed that the patient was positive for antineuronal antibodies that reacted with mouse brain tissue. The molecular reactivity of the serum and fluid obtained from a bulla was positive for the BP180-Ag2 antigen, as determined by ELISA. Additionally, six Parkinson's serum samples without pemphigoid disease were tested as controls, and only one serum sample was reactive to BP180-Ag2. A critical review of the possible pathogenic mechanisms of this rare association is discussed.

01 Dec 2025·MOLECULAR BIOLOGY REPORTS

The dopamine receptor agonist rotigotine attenuated indomethacin-induced enteropathy in the small intestinal mucosa of mice

Article

Author: Han, Xinjie ; Liu, Changchang ; Zhou, Li ; Liu, Xin ; Peng, Bingyan ; Du, Wei ; Li, Ziyu ; Zhao, Yani ; Wang, Zhiyong ; Su, Tian

BACKGROUND:

Nonsteroidal anti-inflammatory drugs induced enteropathy is characterized by disruption of the epithelial barrier and immune homeostasis, resulting in symptoms such as congestion, ulcers and inflammation. Research has suggested that dopamine (DA) exerts a protective effect on the gastroduodenal and colonic mucosa. The present study aimed to explore the effect of DA on NSAID-induced injury to the small intestinal mucosa.

METHODS:

A mouse model of enteropathy induced by indomethacin (Indo, which is a commonly used NSAID) was established by gavage. The DA agonist rotigotine (Roti) was administered alone or in combination with the DA receptor 2 (DRD2) antagonist domperidone (Domp) to model mice to determine the effect of Roti and the key role of DRD2 in this effect. Bilateral vagotomy was performed to determine whether the effect of Roti was mediated by the brain‒gut axis.

RESULTS:

Roti administration attenuated small intestinal injury in Indo-induced model mice. However, Domp administration alone exacerbated this injury. Moreover, Roti mitigated small intestinal injury by increasing Occludin and zonula occludens-1 (ZO-1) expression and decreasing TNF-α and cyclooxygenase 2 (COX-2) expression. However, the effects of Roti were abrogated by Domp. In contrast to Domp, vagotomy before Indo administration did not alter the enteroprotective effects of Roti.

CONCLUSION:

The DA receptor agonist Roti attenuated Indo-induced enteropathy via peripheral DRD2 and could be a potential drug for treating NSAID-mediated enteropathy.

01 Dec 2025·PHARMACEUTICAL RESEARCH

Transdermal Drug Delivery Systems: A Comprehensive Review of Mechanisms, Technologies, and Clinical Applications

Review

Author: Zhang, Tong ; Wang, Cheng ; Wang, Ping ; Kong, Liang ; Qiu, Zhuoya ; Liu, Yongshu ; Zhang, Mengru ; Ren, Yanru ; Xu, Fengxia

BACKGROUND:

Transdermal Drug Delivery Systems (TDDS) offer a non-invasive route for sustained systemic or localized drug delivery. By bypassing hepatic first-pass metabolism and improving bioavailability, TDDS enhances patient compliance, especially in the management of chronic diseases. Drug permeation across the skin is mediated through pathways involving the complex skin barrier, predominantly the stratum corneum, with efficacy influenced by both drug properties and skin physiology.

METHODS:

This review systematically integrates the fundamental mechanisms underlying TDDS, highlights cutting-edge technological advancements developed to overcome the skin barrier, and discusses their expanding clinical applications. The advanced technologies covered include permeation enhancers, vesicular systems (liposomes, transfersomes, ethosomes), microemulsions, microneedles (MNs), responsive systems (pH-, temperature-, enzyme-sensitive), and 3D printing.

RESULTS:

These innovative technologies effectively enhance drug flux, enable targeted delivery, and achieve spatiotemporal control of drug release. Clinically, FDA-approved TDDS formulations have been successfully applied to manage various conditions, including chronic pain (fentanyl, buprenorphine), neurological disorders (rotigotine, rivastigmine), cardiovascular diseases (nitroglycerin, clonidine), hormone replacement, and substance dependence (nicotine). Despite significant clinical value, TDDS still faces challenges such as limitations in delivering macromolecules, potential skin irritation, and inter-individual variability.

CONCLUSION:

Future directions in TDDS research focus on integrating nanotechnology, AI-driven optimization, wearable sensors, and closed-loop smart systems. These integrations aim to achieve greater precision, personalization, and efficiency in transdermal drug delivery, providing valuable insights for future research and translational development.

News (Medical) associated with Rotigotine

15 Sep 2025

·www.fiercepharma.com

BMS sells controlling stake in historic US-China pharmaceutical joint venture

Bristol Myers Squibb originally linked up with China’s Sinopharm Foreign Trade to establish Sino-American Shanghai Squibb Pharmaceuticals as the first U.S.-China pharmaceutical joint venture back in 1982. More than 40 years after establishing the first U.S. pharmaceutical joint venture in China, Bristol Myers Squibb is handing over its controlling stake in the business.BMS has inked an agreement to sell a 60% ownership stake in its China-based joint venture Sino-American Shanghai Squibb Pharmaceuticals (SASS), a BMS spokesperson told Fierce Pharma in an emailed statement. The move is primarily related to manufacturing of older medicines and consumer products in China and doesn't affect Bristol's core business in the country.An internal email circulating online suggests Hillhouse Capital is on the other end of the transaction. Hillhouse is one of Asia’s biggest investment firms, having invested in such biopharma outfits as BeOne Medicines (formerly BeiGene) and Jiangsu Hengrui Pharmaceuticals. The BMS spokesperson didn’t address the buyer’s identity. “As part of our long-term strategy, we continue to align our resources to support evolving business needs across our global network,” the BMS spokesperson said. “The planned sale of our interest in the SASS joint venture reflects the continued implementation of our manufacturing strategy—one that balances internal capabilities with strong external partnerships to enhance regional focus and ensure long-term supply reliability for patients in China and around the world.”BMS will work to assist any employees impacted by the deal and is prioritizing a “smooth and respectful transition” during the ownership change, the spokesperson added. BMS did not elaborate on the financial terms of the agreement.Crucially, the news does not mean that BMS’ core innovative drugs business will cease operation in China. BMS originally linked up with China’s Sinopharm Foreign Trade to establish SASS as the first U.S.-China pharmaceutical joint venture back in 1982. When China opened its economy to foreign entities in the 1980s, multinational corporations were only allowed to enter the country through joint ventures with state-owned, local companies such as Sinopharm.BMS’ China joint venture operates a 58,000-square-meter (roughly 624,307-square-foot) manufacturing facility in Shanghai responsible for production of antibiotics, cardiovascular drugs, analgesics and metabolic medicines, according to the company’s website.BMS’ stake sale isn’t expected to disrupt facility operations or product supply in China. The transaction includes both the sale of the joint venture itself and products that SASS makes exclusively for the mainland China market, including the hepatitis antiviral Baraclude, the buffered aspirin product Bufferin, the vitamin deficiency supplement Theragran, Monopril for high blood pressure and heart failure, and Velosef, which is an antibiotic used to treat bacterial infections. Several other prescription or over-the-counter medicines are listed under the joint venture, according to a database managed by China’s National Medical Products Administration.These days, as China has become more amenable to foreign entities’ participation in the domestic market, legacy joint ventures established by Western drugmakers often maintain a mix of older drug brands, off-patent medicines and consumer products separate from the companies’ innovative therapeutics businesses.Meanwhile, BMS isn’t the only ex-China drugmaker to dispense with certain legacy brands in the country. Last August, Belgium’s UCB said it was selling its mature neurology and allergy business in mainland China to local healthcare asset manager CBC Group and the Abu Dhabi-based investment organization Mubadala in a deal worth $680 million.The deal covered the divestment of seizure drugs Keppra and Vimpat, Neupro for Parkinson’s disease and restless leg syndrome, and the allergy meds Zyrtec and Xyzal, as well as a manufacturing facility in the city of Zhuhai, located in China’s Guangdong Province.The deal was designed, in part, to free up UCB’s focus on potential innovative medicine launches across immunology, neurology and rare diseases in China, the company’s CEO, Jean-Christophe Tellier, said at the time.

AcquisitionLicense out/in

02 Dec 2024

·www.pharmaindustrial-india.com

CBC Group Acquires UCB's Mature Product Portfolio in China

CBC Group has completed the acquisition of global biopharmaceutical company UCB's mature neurology and allergy business in China, in partnership with Mubadala Investment Company, the Abu Dhabi based global investment company. The acquisition marks another successful transaction under CBC's buyout strategy of acquiring key assets from global pharmaceutical companies and a significant step in establishing a market-leading neurology company in China while expanding CBC's portfolio within the region's dynamic pharmaceutical market. The transaction, valued at USD 680 million, includes UCB's well-known brands Keppra, Vimpat, Neupro, Zyrtec, Xyzal, and the Zhuhai manufacturing site. The well-established and trusted medicine portfolio will serve as an anchor asset as CBC builds out a leading integrated central nervous system (CNS) biopharma platform in China, where the market size has reached USD 33 billion. Beyond strengthening CBC's presence in the rapidly growing Chinese healthcare market, the acquisition also enhances the firm's capabilities in meeting the rising demand for neurology and allergy treatments in the wider region. In collaboration with Mubadala, CBC will tap on its proprietary investor-operator approach, deep healthcare expertise and platform synergies to drive operational efficiencies, innovation and scale to benefit more patients across the region. Fu Wei, Chief Executive Officer of CBC Group, said, "There is clear potential within the regional healthcare space to better serve patients with unmet medical needs in this growing CNS therapeutics market, and we are delighted to partner with Mubadala once again. This acquisition complements our existing healthcare ecosystem and aligns with our robust buyout strategy, which is strategically positioned to drive long-term, sustainable value in today's healthcare investing market. Together, we are making a profound impact on the industry by harnessing our combined expertise and capital to not only enhance patient outcomes but also build value for our stakeholders. Leveraging our joint strengths, we are poised to capitalize on synergies and deploy hands-on strategic guidance to make significant strides in CNS market access and innovation." Named 'NeuroGen Pharma', the new company embodies what CBC and Mubadala envision for neuro healthcare innovation. The company will be led by a deep and experienced management team with an extensive track record in the biopharma industry, ensuring a smooth transition to propel it into the next phase of growth. NeuroGen Pharma is expected to deliver quality treatments to a wider reach of patients and play an important role in addressing the evolving neurology treatment needs in China. The company aims to leverage innovative therapies and cutting-edge research to enhance patient outcomes and shape the future of neurology care in the region. Combined net sales for the acquired portfolio in this transaction were Euro131 million in 2023. The strategic acquisition builds on CBC's collaboration with Mubadala, which includes their investment in CBC Healthcare Infrastructure Platform's (HIP) first life science real assets venture and the joint investment in the USD 315 million fundraising round for CBC-backed Hasten, a leading pharmaceutical company. Mohamed Albadr, Head of Asia at Mubadala, said, "We are thrilled to partner with CBC Group to support the growth and development of NeuroGen Pharma as it scales to a leading entity in China and delivers transformative medicines to patients. Built on a strong foundation of proven therapies and driven by innovation and cutting-edge research, the company is uniquely positioned to address the growing need for advanced neurology and allergy treatments while aligning with our commitment to enhancing access to care and growth in the healthcare system." Jean-Christophe Tellier, CEO at UCB, said, "In the short term, UCB is exploring the launch of novel medicines in immunology, neurology, and rare diseases in China. Our dedication to serving patients with unmet needs in China remains steadfast. Building on our 28-year presence in the country, we are committed to driving patient outcomes through continued collaboration with local partners and fostering innovation. We are convinced that the CBC Group and Mubadala are the ideal partners to advance the medicine portfolio and continue to improve the lives of people living with neurology and allergy diseases in mainland China."

Acquisition

02 Dec 2024

·www.pharmaceutical-technology.com

CBC acquires UCB’s neurology and allergy business in China

The new company aims to deliver quality treatments and address evolving neurology treatment needs in the country. Credit: Volha_R/Shutterstock. CBC Group, in partnership with the Mubadala Investment Company, has completed the strategic acquisition of Union Chimique Belge’s ( UCB ) mature neurology and allergy business in China for $680m. The move comes after UCB agreed to sell and license its business in August 2024. The deal encompasses UCB’s Zhuhai manufacturing site and its brands Xyzal, Keppra, Zyrtec, Vimpat and Neupro. They are set to be the cornerstone assets for CBC as it develops an integrated central nervous system (CNS) biopharma platform in China. Working alongside Mubadala, CBC plans to leverage its platform synergies, investor-operator approach and healthcare expertise, to optimise operations, foster innovation and expand its reach to benefit more patients in the region. The new entity formed from this acquisition called NeuroGen Pharma is set to offer neuro healthcare innovation services. It will be spearheaded by a management team with a solid background in the biopharma industry, which is expected to ensure a seamless transition and drive future growth. The company aims to deliver quality treatments and address the evolving neurology treatment needs in the country. The acquired portfolio reported combined net sales of €131m ($138m) in 2023. The strategic acquisition is part of a broader partnership between CBC and Mubadala, which also includes their joint investment in the $315m fundraising round for Hasten and an investment in CBC Healthcare Infrastructure Platform’s first life science real assets venture. CBC Group CEO Fu Wei stated: “There is clear potential within the regional healthcare space to better serve patients with unmet medical needs in this growing CNS therapeutics market, and we are delighted to partner with Mubadala once again. “This acquisition complements our existing healthcare ecosystem and aligns with our robust buyout strategy, which is strategically positioned to drive long-term, sustainable value in today’s healthcare investing market.”

Acquisition

100 Deals associated with Rotigotine

External Link

KEGG	Wiki	ATC	Drug Bank
D05768	Rotigotine	N04BC09	DB05271

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Parkinson Disease	European Union	UCB Pharma SA	15 Feb 2006
Parkinson Disease	Iceland	UCB Pharma SA	15 Feb 2006
Parkinson Disease	Liechtenstein	UCB Pharma SA	15 Feb 2006
Parkinson Disease	Norway	UCB Pharma SA	15 Feb 2006
Restless Legs Syndrome	European Union	UCB Pharma SA	15 Feb 2006
Restless Legs Syndrome	Iceland	UCB Pharma SA	15 Feb 2006
Restless Legs Syndrome	Liechtenstein	UCB Pharma SA	15 Feb 2006
Restless Legs Syndrome	Norway	UCB Pharma SA	15 Feb 2006

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Primary Parkinson's disease	Phase 3	China	Shandong Luye Pharmaceutical Co., Ltd.	03 Feb 2020
Kidney Failure, Chronic	Phase 3	Germany	UCB BioSciences GmbH	24 Jan 2012
Gastrointestinal dysfunction	Phase 3	United States	UCB Pharma GmbH	01 Jan 2012
Choreoathetosis	Phase 3	Italy	Schwarz Pharma, Inc.	25 May 2005
Dyssomnias	Phase 3	Germany	UCB Pharma GmbH	01 Nov 2004
Young onset Parkinson disease	Phase 3	Australia	UCB Pharma GmbH	01 Aug 2002
Young onset Parkinson disease	Phase 3	Austria	UCB Pharma GmbH	01 Aug 2002
Young onset Parkinson disease	Phase 3	Belgium	UCB Pharma GmbH	01 Aug 2002
Young onset Parkinson disease	Phase 3	Croatia	UCB Pharma GmbH	01 Aug 2002
Young onset Parkinson disease	Phase 3	Czechia	UCB Pharma GmbH	01 Aug 2002

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


MDS2025	Phase 3	Parkinson Disease	294	LY03003	zvutvhayst(ykcyjxanqz) = zatiddoeki cgrrtvlwsx (vpwvomimbg ) View more	Positive	05 Oct 2025
				Placebo	zvutvhayst(ykcyjxanqz) = ihdzocjwac cgrrtvlwsx (vpwvomimbg ) View more
NCT03992196 (CTgov)	Phase 3	Restless Legs Syndrome	10	Rotigotine (Rotigotine Final Dose 2 mg/24 h)	nvdbxsmexq = biermktats iltugermgo (ijfyeernza, gztmjmsczl - igntuzeqhy) View more	-	30 Oct 2023
				Rotigotine (Rotigotine Final Dose 3 mg/24 h)	nvdbxsmexq = xehdirequi iltugermgo (ijfyeernza, zomdyxbgoy - dxhxucdxdz) View more
NCT03728933 (CTgov)	Phase 3	Restless Legs Syndrome	23	Placebo	vrnbbqeiju(gdpejdeqoe) = xaogsqnpct qtuhljaqhj (dmkazscvmd, 6.8) View more	-	26 Oct 2023
NCT04937452 (CTAD2023)	Phase 2	Frontotemporal Dementia	75	Rotigotine 4 mg/day	reovmtjtho(gzwehfxdme) = myjhgqkyus qoatwvwbmu (ctwnucdjxv, −0.669 - 1.037)	Negative	24 Oct 2023
				Rotigotine 6 mg/day	reovmtjtho(gzwehfxdme) = csbhaxnqkq qoatwvwbmu (ctwnucdjxv, − 0.225 - 1.037)
NCT04571164 (NEWS) Manual	Phase 3	Parkinson Disease	294	LY03003	vesqnzxuqc(aqmuakaxie) = ，與安慰劑組相比，LY 03003組統一帕金森病評分量表(UPDRS)Ⅱ+Ⅲ評分較基綫顯著改善，兩組差異具有統計學意義（ P＜0.001 ）。 arikinmhnw (bcblqmmvwq ) View more	Positive	19 Jul 2022
				Placebo
NCT02365870 (ANXPD, CTgov)	Phase 4	Anxiety Disorders \| Parkinson Disease	4	rotigotine transdermal patch (Rotigotine)	xskhavbbpg(ypzwbmbgfp) = klvejqvfgg vfegzmylxx (kwquhkthgi, 0) View more	-	19 Mar 2020
				placebo (Placebo)	xskhavbbpg(ypzwbmbgfp) = dpxpzjfutn vfegzmylxx (kwquhkthgi, 5.1) View more
NCT03103919 (CTgov)	Phase 4	Parkinson Disease, Secondary \| Parkinson Disease	40	Kinesia-ONE™+Rotigotine (Rotigotine + Standard Care)	pksalzjtik(qtdcbnixjv) = unqkumdehn tdwvkrslrb (npdiwehbwb, izaoeaakvn - dyayeezhtc) View more	-	19 Feb 2019
				Kinesia-360™+Rotigotine (Rotigotine + Standard Care + Kinesia-360™ Wearable Device)	pksalzjtik(qtdcbnixjv) = ehhdbzqaab tdwvkrslrb (npdiwehbwb, wxxibyjwud - ydoetsbrxa) View more
NCT02230904 (PD0018, Pubmed \| Curr Med Res Opin) Manual	Phase 1	Parkinson Disease	57	rotigotine (Treatments A)	zjkixazzdz(pkrkyssvgx) = sradlivxiv auhrymslte (wzadgrpioa, 1.635) View more	Positive	01 Jul 2018
				rotigotine (Treatments B)	jicerygetq(ddmsmqyhhb) = ftkjkewthz cbrwdwquyt (fpuixambws )
NCT01646255 (SP1037, Pubmed \| Parkinsonism Relat Disord 1 \| Parkinsonism Relat Disord 2) Manual	Phase 3	Parkinson Disease	346	Rotigotine	swfefeskko(vgxymflvus): difference = -1.20 (95% CI, -1.83 to -0.57), P-Value = 0.0002 View more	Positive	01 Nov 2017
				Placebo
NCT01495793 (Pubmed \| Sleep Med)	Phase 2	Restless Legs Syndrome	24	Rotigotine transdermal system 0.5 mg/24 h	dtqtfklash(mkbnlucrtj) = qssbpzxapu rcgjipkxjw (fwxfetbuzn ) View more	-	01 Apr 2017
				Rotigotine transdermal system 1 mg/24 h	dtqtfklash(mkbnlucrtj) = uxdhlzrega rcgjipkxjw (fwxfetbuzn ) View more

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