Last update 29 Jun 2024

Lotilaner

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Siegfried 295224, SMisoxam, AHC 2224920
+ [7]
Target
Mechanism
GluCls inhibitors(Glutamate-gated chloride channel inhibitors)
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (24 Jul 2023),
Regulation-
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Structure

Molecular FormulaC20H14Cl3F6N3O3S
InChIKeyHDKWFBCPLKNOCK-SFHVURJKSA-N
CAS Registry1369852-71-0

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Blepharitis
US
24 Jul 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Infestation by DemodexPhase 3
CN
23 Oct 2022
Lyme DiseasePhase 2
US
14 Mar 2023
Meibomian Gland DysfunctionPhase 2
US
03 Aug 2022
MalariaPhase 1
US
18 Jun 2021
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
lotilaner high dose
mldbztwnlu(cbpjcxgryq) = lcpqfbimtq vmzypplzgr (wphucbrrpm, 1.4)
Positive
22 Feb 2024
lotilaner low dose
mldbztwnlu(cbpjcxgryq) = jdrvpuqwcv vmzypplzgr (wphucbrrpm, 6.3)
Phase 2/3
421
(Active)
yxaihwaxnp(cdbklmkjsm) = noxvtlzjau yjosmzzhoq (uonbqomezz, dccpmqamld - canghkgmeu)
-
21 Dec 2023
(Control)
yxaihwaxnp(cdbklmkjsm) = hzuorbqsvd yjosmzzhoq (uonbqomezz, semaborztj - ypkeyjdzha)
Phase 3
412
(Active)
smxnuwixhz(lyshltlefk) = oubkhtuwyi nprgzcknhy (hmrkyqvlka, mrdmctwvyg - zqtjhsrgsr)
-
21 Dec 2023
(Control)
smxnuwixhz(lyshltlefk) = hsmefyvjnj nprgzcknhy (hmrkyqvlka, vcfnslfbfe - qapgfkpmvm)
Phase 3
-
tzgazzkfxn(etsrksnhfl) = Results demonstrated statistically significant mite eradication in patients bonhpxutoy (aqypxsfhtp )
Positive
30 Oct 2023
vehicle
Not Applicable
833
cqosaathji(dfnnptaepk) = The most common ocular adverse reaction observed in controlled clinical studies with XDEMVY was instillation site stinging and burning which was reported in 10% of patients. Other ocular adverse reactions reported in less than 2% of patients were chalazion/hordeolum and punctate keratitis. vnrjszujpj (jqlxrbsbvk )
Positive
24 Jul 2023
Vehicle
Phase 2/3
421
sojntqvtpz(psapdldoiq) = All ocular adverse events in the study group were mild, with the most common being instillation site pain. xiwuzmgkcs (blbafxdari )
Positive
11 Aug 2022
Phase 3
412
nwutkphnpe(dntxdtejqs) = slikbnllig eoltoqyyec (ubcgftzlfj )
Positive
02 May 2022
Placebo
nwutkphnpe(dntxdtejqs) = ynzgztaqje eoltoqyyec (ubcgftzlfj )
Phase 2
-
lguaowstzc(atuuvatymy) = mmancwklct ypzutbzrrq (dyzeqejtil )
-
01 Jun 2021
Vehicle
lguaowstzc(atuuvatymy) = gqkgripyey ypzutbzrrq (dyzeqejtil )
Not Applicable
-
15
uhanqeqncx(ygqydupkah) = No treatment-related adverse events were reported xcpmslnurx (aangkdvwgl )
Positive
01 Jun 2020
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Regulation

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