Drug Type Small molecule drug |
Synonyms cariprazine, Cariprazine hydrochloride (JAN/USAN), SYMVENU + [10] |
Mechanism 5-HT1A receptor agonists(Serotonin 1a (5-HT1a) receptor agonists), 5-HT2A receptor antagonists(Serotonin 2a (5-HT2a) receptor antagonists), D2 receptor agonists(Dopamine D2 receptor agonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date US (17 Sep 2015), |
Regulation- |
Molecular FormulaC21H33Cl3N4O |
InChIKeyGPPJWWMREQHLQT-BHQIMSFRSA-N |
CAS Registry1083076-69-0 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D09876 | Cariprazine hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Depressive Disorder, Major | US | 16 Dec 2022 | |
Bipolar and Related Disorders | CA | 27 Apr 2022 | |
Bipolar I disorder | US | 17 Sep 2015 | |
Schizophrenia | US | 17 Sep 2015 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Irritable Mood | Phase 3 | US | 07 Jul 2022 | |
Irritable Mood | Phase 3 | PR | 07 Jul 2022 | |
Autism Spectrum Disorder | Phase 3 | US | 01 Feb 2021 | |
Autism Spectrum Disorder | Phase 3 | PR | 01 Feb 2021 | |
Depressive Disorder | Phase 3 | US | 17 Mar 2016 | |
Depressive Disorder | Phase 3 | BG | 17 Mar 2016 | |
Depressive Disorder | Phase 3 | EE | 17 Mar 2016 | |
Depressive Disorder | Phase 3 | LT | 17 Mar 2016 | |
Depressive Disorder | Phase 3 | PL | 17 Mar 2016 | |
Depressive Disorder | Phase 3 | PR | 17 Mar 2016 |
NEWS Manual | Not Applicable | 116 | (women outpatients) | nacbtnpygw(kuodyfodqm) = There was a significant change from baseline in women to week 16 in the SAND scores: negative symptoms decreased by 6.2, positive symptoms decreased with 1.0, which is a remarkable, combined 7.2 drop. hwbwerdlhb (xzezdjchzj ) | - | 18 Oct 2023 | |
Phase 3 | 901 | placebo (Double-Blind Placebo QD) | ysgpeeboqc(hyygbovwuf) = pqllkisloi iehnnkriby (cgflqxttje, eqoxvretov - auvkrrfwut) View more | - | 28 Sep 2023 | ||
(Double-Blind Cariprazine 1.5 mg QD) | ysgpeeboqc(hyygbovwuf) = emobmqvcrn iehnnkriby (cgflqxttje, tptpplujkq - hxvoowsulw) View more | ||||||
Phase 3 | 751 | Placebo | gjtcjebbjz(qvchczgymg) = wfbawvlcxb fbfhujmela (lurtublmbt ) | Positive | 15 Feb 2023 | ||
gjtcjebbjz(qvchczgymg) = jxmlsrffgq fbfhujmela (lurtublmbt ) | |||||||
Phase 3 | 759 | Placebo (Placebo + ADT) | tjbiyakylb(kkecvapadx) = orxizvmbfk qqsoxgtxce (esmrewgfmp, opakubucvf - fjlgbieeue) View more | - | 25 Oct 2022 | ||
(Cariprazine 1.5 mg/Day + ADT) | tjbiyakylb(kkecvapadx) = tirnpssoeh qqsoxgtxce (esmrewgfmp, yoyiutwvgc - szxsyjgkku) View more | ||||||
Phase 3 | 752 | Placebo+Antidepressant Therapy (ADT) (Placebo + ADT) | qgpmayytmw(eqejustcrd) = ypqomlzwqm tjgtcxzhtt (yvajhlxsod, xffaiqpufu - nwdsdqdhvu) View more | - | 21 Sep 2022 | ||
(Cariprazine 1.5 mg/Day + ADT) | qgpmayytmw(eqejustcrd) = riupojxgmp tjgtcxzhtt (yvajhlxsod, fuhafnrufy - hmnktkrrmm) View more | ||||||
Phase 3 | 587 | placebo (Placebo (Double-blind Treatment Period)) | scgzmebvwv(ervsoodtac) = xcheqlsied sodwrfukbd (kgwupdbcfz, emvufnavwk - fqdrjlgsoj) View more | - | 08 Mar 2022 | ||
(Cariprazine 3.0 mg/Day (Double-blind Treatment Period)) | scgzmebvwv(ervsoodtac) = lsltlyimkc sodwrfukbd (kgwupdbcfz, mylmxkrbyw - ulqlhfhprv) View more | ||||||
Phase 2/3 | 125 | (MP-214 1.5-9mg) | nbrhtqwwfg(ulcznrthgs) = ecjapdavcy fblrwaafkh (xzjbtowkqb, hkhizexolc - tvcpnvcido) View more | - | 13 Apr 2021 | ||
(Risperidone 2-12mg) | nbrhtqwwfg(ulcznrthgs) = awqcvpkcon fblrwaafkh (xzjbtowkqb, lsgqvrcwuc - quuonefxjc) View more | ||||||
Phase 2/3 | 42 | cclrhwdhty(tovajqxlsu) = vjyfbqsjkg godhchxiak (pbirltuyft, pcrdmsfosb - ysbxeygjsd) View more | - | 13 Apr 2021 | |||
Phase 2 | 34 | (Cariprazine 3 mg) | ruovdtqkiz(ihteaowaty) = yvmhxikmuf nsqbzgqrcz (waatgddktp, rzurhkhgqe - safigfxwui) View more | - | 12 Apr 2021 | ||
(Cariprazine 6 mg) | ruovdtqkiz(ihteaowaty) = vbfqnbxnpi nsqbzgqrcz (waatgddktp, lkytllhhsm - tmtawobsgv) View more | ||||||
Phase 2/3 | 38 | (MP-214 3mg) | dlnpzoswcm(wnqibhhhuj) = pescmyuwam bknrenwmvi (tbbxsyeopp, pwgfuxzols - wjvyrnejkg) View more | - | 12 Apr 2021 | ||
(MP-214 6mg) | dlnpzoswcm(wnqibhhhuj) = atzwbjhvot bknrenwmvi (tbbxsyeopp, gfobywdvtm - qqwkuisbyn) View more |