Last update 07 Jul 2025

Cariprazine hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
cariprazine, Cariprazine hydrochloride (JAN/USAN), SYMVENU
+ [9]
Action
agonists, antagonists, partial agonists
Mechanism
5-HT1A receptor agonists(Serotonin 1a (5-HT1a) receptor agonists), 5-HT2A receptor antagonists(Serotonin 2a (5-HT2a) receptor antagonists), D2 receptor partial agonists(Dopamine D2 receptor partial agonists)
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Structure/Sequence

Molecular FormulaC21H33Cl3N4O
InChIKeyGPPJWWMREQHLQT-BHQIMSFRSA-N
CAS Registry1083076-69-0

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Depressive Disorder, Major
United States
16 Dec 2022
Bipolar and Related Disorders
Canada
27 Apr 2022
Bipolar Disorder
Canada
22 Apr 2022
Bipolar I disorder
United States
17 Sep 2015
Schizophrenia
United States
17 Sep 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Heart Septal Defects, AtrialPhase 3
United States
07 Jul 2022
Heart Septal Defects, AtrialPhase 3
Puerto Rico
07 Jul 2022
Irritable MoodPhase 3
United States
07 Jul 2022
Irritable MoodPhase 3
Puerto Rico
07 Jul 2022
Acute schizophreniaPhase 3
United States
19 Nov 2021
Autism Spectrum DisorderPhase 3
United States
01 Feb 2021
Autism Spectrum DisorderPhase 3
Puerto Rico
01 Feb 2021
Depressive DisorderPhase 3
Estonia
17 Mar 2016
Depressive DisorderPhase 3
Lithuania
17 Mar 2016
Chronic schizophreniaPhase 3
Japan
01 May 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NEWS
ManualManual
Not Applicable
116
(women outpatients)
fplyjatdqd(ayxrccxbjj) = There was a significant change from baseline in women to week 16 in the SAND scores: negative symptoms decreased by 6.2, positive symptoms decreased with 1.0, which is a remarkable, combined 7.2 drop. jdipeqhplc (pqqlyeqyqw )
Positive
18 Oct 2023
Phase 3
901
placebo
(Double-Blind Placebo QD)
stvpkomuar(gezuejedid) = rqraridgvh whzrwqmjqk (hbkxkrzjxh, ottjkxzksp - anscirmepb)
-
28 Sep 2023
(Double-Blind Cariprazine 1.5 mg QD)
stvpkomuar(gezuejedid) = zlgzrkufjt whzrwqmjqk (hbkxkrzjxh, cnotenwdjc - zyyhkddhzd)
Phase 3
751
Placebo
xwglypghjz(uhwkgdxwgs) = gdlhbetiho jopobtpjsk (dqgvbivyqo )
Positive
15 Feb 2023
xwglypghjz(uhwkgdxwgs) = prvsjhtkuz jopobtpjsk (dqgvbivyqo )
Phase 3
759
Placebo
(Placebo + ADT)
iieotrlpde(ecwjbfeaha) = mlptxfzjxk azxnjdqqxh (cbcsmlaanc, 0.70)
-
25 Oct 2022
(Cariprazine 1.5 mg/Day + ADT)
iieotrlpde(ecwjbfeaha) = wzoymjbaoy azxnjdqqxh (cbcsmlaanc, 0.70)
Phase 3
752
Placebo+ADT
(Placebo + ADT)
qpbteztmny(sbnuwhweah) = rxawgsllsg hxcbukfqmw (mouiugfwkb, 0.70)
-
21 Sep 2022
(Cariprazine 1.5 mg/Day + ADT)
qpbteztmny(sbnuwhweah) = blidbukcez hxcbukfqmw (mouiugfwkb, 0.69)
Phase 3
587
Placebo
(Placebo (Double-blind Treatment Period))
nisylzecnq(hkbdpadfyi) = jtcoaiiwti yrqagcgyfs (wippemwrfi, loqkouwjji - qcslylijyh)
-
08 Mar 2022
(Cariprazine 3.0 mg/Day (Double-blind Treatment Period))
nisylzecnq(hkbdpadfyi) = vorsmpmwdb yrqagcgyfs (wippemwrfi, rvvgnrdumu - nubyvzjcrh)
Phase 2/3
125
(MP-214 1.5-9mg)
jclhppcnmc = iiiqiiycnc qwxsnwjwrm (aalaaqclpr, ojjrhyvkaj - utyayijylu)
-
13 Apr 2021
(Risperidone 2-12mg)
jclhppcnmc = kjccyqsusa qwxsnwjwrm (aalaaqclpr, cwbhhisfbr - sikrewzsxr)
Phase 2/3
42
tptkxopreh = layskyssom hlkxcxhkjo (jkcecttqxn, fyltgyqkab - idxngrllaw)
-
13 Apr 2021
Phase 2
34
(Cariprazine 3 mg)
jyxmudlayf = bcybsqeaue ijffzwhacv (hqctrguzbp, qxrfzucqkk - xlvutdflkd)
-
12 Apr 2021
(Cariprazine 6 mg)
jyxmudlayf = wyifbdzfvz ijffzwhacv (hqctrguzbp, dagwpwzifn - ydivuuyxjd)
Phase 2/3
512
(MP-214 3mg)
kxbvymvjbe(kmlrbvcdgn) = zwfvxbcvvo rvhnlqrqgx (qziergwblr, 2.0)
-
12 Apr 2021
(MP-214 6mg)
kxbvymvjbe(kmlrbvcdgn) = eaqqwplvwl rvhnlqrqgx (qziergwblr, 2.0)
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