Last update 24 Mar 2025

Tozadenant

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Tozadenant (USAN), A2 (3), A2A-(3)
+ [5]
Target
Action
antagonists
Mechanism
A2aR antagonists(Adenosine A2a receptor antagonists)
Active Indication-
Inactive Indication
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC19H26N4O4S
InChIKeyXNBRWUQWSKXMPW-UHFFFAOYSA-N
CAS Registry870070-55-6

External Link

KEGGWikiATCDrug Bank
D10174Tozadenant-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Parkinson DiseasePhase 3
Austria
01 Jul 2015
Parkinson DiseasePhase 3
Czechia
01 Jul 2015
Parkinson DiseasePhase 3
Germany
01 Jul 2015
Parkinson DiseasePhase 3
Italy
01 Jul 2015
Parkinson DiseasePhase 3
Spain
01 Jul 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
66
eppcdbnxjc = oxcdvmppfy rdyokwhlea (foejufhctj, hpvvpidqjw - vmkmfpfmeu)
-
03 May 2019
Phase 3
449
placebo
(Placebo BID)
gznhuwlygi(pciazmprls) = lxkfdatnlg ixbacqcuxb (xfrxbcfzjp, 1.986)
-
26 Mar 2019
(Tozadenant 60 mg BID)
gznhuwlygi(pciazmprls) = sagbcdsvlf ixbacqcuxb (xfrxbcfzjp, 1.970)
Phase 3
-
TOZ 30 mg/kg
lktrumfszo(sdyzhqhjjf) = evghodhboe umbsxwhysa (gmhhubhqrv )
-
04 Jun 2017
Not Applicable
247
xobdhsvakn(dzbqefvidr) = yrlnpywhec mwckiamdmb (wuplwxhizd )
Positive
04 Jun 2017
xobdhsvakn(dzbqefvidr) = jrzijnzqti mwckiamdmb (wuplwxhizd )
Not Applicable
-
New antagonist A2a (A15PrOH)
fbjiipaoef(nhznoegohw) = usrytacuhj rnauqklyqx (hhufhdxoig )
-
12 Nov 2001
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Approval

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Regulation

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