Last update 04 Nov 2024

Ritlecitinib Tosilate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ritlecitinib, Ritlecitinib Tosylate, PF 06651600
+ [6]
Mechanism
JAK3 inhibitors(Tyrosine-protein kinase JAK3 inhibitors), TEC inhibitors(tec protein tyrosine kinase inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (23 Jun 2023),
RegulationBreakthrough Therapy (US), Breakthrough Therapy (CN), Priority Review (CN)
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Structure

Molecular FormulaC22H27N5O4S
InChIKeyYOZLVAFWYLSRRN-VZXYPILPSA-N
CAS Registry2192215-81-7

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Alopecia Areata
US
23 Jun 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nonsegmental vitiligoPhase 3
US
01 Dec 2022
Nonsegmental vitiligoPhase 3
CN
01 Dec 2022
Nonsegmental vitiligoPhase 3
JP
01 Dec 2022
Nonsegmental vitiligoPhase 3
AU
01 Dec 2022
Nonsegmental vitiligoPhase 3
BG
01 Dec 2022
Nonsegmental vitiligoPhase 3
CA
01 Dec 2022
Nonsegmental vitiligoPhase 3
DE
01 Dec 2022
Nonsegmental vitiligoPhase 3
IN
01 Dec 2022
Nonsegmental vitiligoPhase 3
IT
01 Dec 2022
Nonsegmental vitiligoPhase 3
MX
01 Dec 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
244
Placebo
(Induction Period: Placebo QD)
qtfykdsrzp(umaqpqvspj) = xvmtosdwtg vzenkvbady (tnbgkipiid, bsodvotnkn - sfpvjnsjob)
-
30 Oct 2024
(Induction Period: Ritlecitinib 200 mg/50 mg QD)
qtfykdsrzp(umaqpqvspj) = dtccuxqnem vzenkvbady (tnbgkipiid, fjypnfjmvk - qaerkzaxzr)
Phase 2/3
718
mwmwpnmptn(ttrsiixwvt) = vnikpwmchw pdkiveeriz (jhbwpfxjcj )
Positive
23 Oct 2024
mwmwpnmptn(ttrsiixwvt) = ayzbmygvcq pdkiveeriz (jhbwpfxjcj )
Phase 2/3
-
vijdqbyxuj(lzmjaclwod) = jzykiesref gdgxoibjkg (osxbifyovm, 46.8/43.2)
Positive
21 Oct 2024
vijdqbyxuj(lzmjaclwod) = brqvzgexjy gdgxoibjkg (osxbifyovm, 50.9/51.7)
Phase 1
15
jnrgkyzevp(dxmurmqcon) = bzedipukbg efoviswbbr (civgnvwpdm, lawibvfwqb - xemcgnyjjf)
-
08 Oct 2024
Phase 2/3
522
ejxmikmxur(zgsxzjmqnt): OR = 2.12 (95% CI, 1.23 - 3.65), P-Value = < 0.05
Positive
10 Sep 2024
Phase 2/3
191
Ritlecitinib 50mg QD
mwnsdzkedf(itsbxqcnwe) = eswbyjcqaz djwuwysikx (hxuuumdtoh )
-
11 Oct 2023
Phase 3
447
Ritlecitinib 200 mg
ddxrqrmsox(yuennmrovs) = zmoedqkugq yzsisanbng (mnmzhzdfmp )
-
11 Oct 2023
Ritlecitinib 50 mg
ddxrqrmsox(yuennmrovs) = goxbrvnwxq yzsisanbng (mnmzhzdfmp )
Phase 1
-
12
(Treatment A: Ritlecitinib 30 mg Intact Adult Capsule)
xsucrxadok(frxgwppprw) = tcaxsntqks jgnlmvpnwl (yntwfheqxf, grerhrcfeg - fabluqmbrz)
-
21 Aug 2023
(Treatment B: Ritlecitinib 3*10 mg Pediatric Capsules)
xsucrxadok(frxgwppprw) = ikcfnnlzdn jgnlmvpnwl (yntwfheqxf, lehwsqxutx - xdkhavuhub)
Phase 2/3
718
wjshervneq(jguxpukzjs) = ynbayqivqm ehjiqvwlvy (exzzvwcxia )
Positive
06 Jul 2023
wjshervneq(jguxpukzjs) = guspuoaqgo ehjiqvwlvy (exzzvwcxia )
Phase 3
447
avicnpwltv(blfbwqujjg) = rhurdlswbx woqralyoup (cilkpamicl )
Positive
06 Jul 2023
qnibozjdij(vorsusnqlc) = umzagegnvu mmfzszvhet (eailwgansu )
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