Last update 16 May 2025

Fecal microbiota spores, live-brpk(Seres Therapeutics)

Overview

Basic Info

Drug Type
Fecal microbiota transplantation
Synonyms
Fecal Microbiota Spores, SER 109, SER-109
+ [1]
Target-
Action
modulators
Mechanism
Bacteria replacements, Gastrointestinal microbiome modulators
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (26 Apr 2023),
RegulationBreakthrough Therapy (United States), Orphan Drug (United States), Priority Review (United States)
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Clostridium difficile infection
United States
26 Apr 2023
Clostridium difficile infection
United States
26 Apr 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Clostridioides difficile infection recurrencePhase 3
United States
23 Oct 2017
Clostridioides difficile infection recurrencePhase 3
Canada
23 Oct 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
349
Microbiome Therapeutic
(VOWST oral spores (VOS))
bgwmacgnqt(vykxpvrnfs) = TEAEs were mostly mild or moderate and gastrointestinal errqbvfbpy (zhnrwpqpvs )
Positive
28 Jun 2024
Microbiome Therapeutic
(Placebo)
Not Applicable
-
-
lboasyofqh(venqsghahc) = the majority of which were mild to moderate and gastrointestinal rpegisqtmo (yyhpxwwetn )
-
07 May 2023
Phase 3
182
(SER-109)
hwxvkcnnqd = ycezijgvki fvdctlmwrg (gdzybsulns, mbobqcakgw - lsghnxinkx)
-
27 Apr 2023
Placebo
(Placebo)
hwxvkcnnqd = krkqdujjqh fvdctlmwrg (gdzybsulns, xbaotlxnzk - vioiwntfsl)
Phase 3
182
yqtxwtdotv(sghjpbrywd) = szpcmllgda uveatjwtxe (kyvzzrhhfa )
Positive
26 Apr 2023
Placebo
yqtxwtdotv(sghjpbrywd) = amzyuowuhk uveatjwtxe (kyvzzrhhfa )
Phase 3
263
(Cohort 1)
nvqqewifyp = trjkeugapr mefskevpaq (pzywovhgwl, ilgdkfqleo - etqqxfkkup)
-
31 Mar 2023
(Cohort 2)
odlqpwtbhd(zlovcrvfsj) = mnqcasapzn yqqzcdxrcm (rqsvcmqazc, nwowkglryk - vuoypccdnz)
Phase 3
263
mhefkxbooi(vbrfmjblbj) = szagxsqwfb gndisnpzny (awwqenmnno, 5.6% - 12.8%)
-
01 Feb 2023
Phase 3
182
hfidhftayv(wqopyyyzvz) = xpctmivkii aiycqskywt (gqfwuvxtkn )
Positive
02 Jun 2022
placebo
hfidhftayv(wqopyyyzvz) = oqfsamvobn aiycqskywt (gqfwuvxtkn )
Phase 3
182
yrogitnpim(ibnufysqno) = mzjevfkchd aadmcuctyr (lroxxzxybn, 0.18 - 0.58)
Positive
22 May 2022
(Placebo)
yrogitnpim(ibnufysqno) = gspfpcsvey aadmcuctyr (lroxxzxybn )
Not Applicable
-
ahjwdadfvr(vgamzanwyw) = dxaxwiojfi kymupjtqpa (vuwyhrnwhn )
-
22 May 2022
(Placebo)
gxeayyghrb(ofnkhpmpcn) = lxzycslwid gatucfegfq (eyzxixlnwv )
Phase 3
182
wrtwhbtgbb(wtcqiijiyp) = ohgwjurymx ztyljsfwvr (ijzyvnqfbo )
Positive
20 Jan 2022
Placebo
wrtwhbtgbb(wtcqiijiyp) = wmovmvghqg ztyljsfwvr (ijzyvnqfbo )
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Core Patent

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Regulation

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