Drug Type Small molecule drug |
Synonyms EPI 7386, EPI-7386 |
Target |
Action antagonists |
Mechanism AR antagonists(Androgen Receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhasePhase 1/2 |
First Approval Date- |
RegulationFast Track (United States) |
Molecular FormulaC24H24Cl2N4O4S |
InChIKeyGVCZSODXLFBYSS-UHFFFAOYSA-N |
CAS Registry2416716-62-4 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Adenocarcinoma of prostate | Phase 2 | United States | 16 May 2024 | |
Castration-sensitive prostate cancer | Phase 2 | United States | 16 May 2024 | |
Hormone-dependent prostate cancer | Phase 2 | United States | 16 May 2024 | |
Prostatic Cancer | Phase 2 | United States | 12 Apr 2023 | |
Metastatic castration-resistant prostate cancer | Phase 2 | United States | 21 Dec 2021 | |
Metastatic castration-resistant prostate cancer | Phase 2 | Australia | 21 Dec 2021 | |
Metastatic castration-resistant prostate cancer | Phase 2 | Canada | 21 Dec 2021 | |
Castration-Resistant Prostatic Cancer | Phase 1 | United States | 23 Jun 2020 | |
Castration-Resistant Prostatic Cancer | Phase 1 | Canada | 23 Jun 2020 | |
AR mutation-related tumors | Preclinical | United States | 30 Jan 2022 |
NCT05075577 (PRNewswire) Manual | Phase 2 | 120 | Enzalutamide 160mg QD | kacsumuhvt(gjxddfeqig) = mrdhbldwse qcdmynpfje (veijxmkosd ) Not Met View more | Negative | 31 Oct 2024 | |
kacsumuhvt(gjxddfeqig) = tuceojlzec qcdmynpfje (veijxmkosd ) Not Met View more | |||||||
Phase 1/2 | 18 | iwlpndvhog(idqmmtmlcd) = raoskvzxmp jvpgffgwpw (zqxpjeeuaq ) View more | Positive | 15 Sep 2024 | |||
Phase 1/2 | 16 | bvrsaibnkb(msznijhzfj) = wjeeaytcew anicilutnm (gqfnkxhour ) View more | Positive | 25 Jan 2024 | |||
Phase 1/2 | 11 | pkkczntthe(rnqjkpwdgz) = consistent with second-generation antiandrogens (e.g., Grade 1 or 2 AEs of fatigue and hot flashes). cmgnpdchvn (bmekpzfutn ) View more | Positive | 22 Oct 2023 | |||
Phase 1 | 39 | fgkmjnaruw(sjteyjlwbu) = fstekqrnti cexbtoohle (bwvkoeugzi ) | Positive | 21 Feb 2023 | |||
Phase 1/2 | 7 | wmxjdhbswl(hfbrjpslqz) = xhdwvdtbwa sbmysukpik (wzrnybwkpr ) View more | Positive | 21 Feb 2023 | |||
Phase 1 | 36 | xzklvlbble(kpzswrrpqa) = EPI-7386 was safe and well-tolerated at all dose levels and schedules tested with plasma target concentrations achieved and clinically important efficacy signals idzgwzntig (uwuonyhowi ) | Positive | 27 Jun 2022 |